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Showing 1-16 of 16 results for "AB1761-I" within Papers
Meilinn Tram et al.
Neurobiology of pain (Cambridge, Mass.), 14, 100134-100134 (2023-12-15)
Several gaps in knowledge exists in our understanding of orofacial pain. Some of these include type of peripheral sensory innervation in specific tissues, differences in innervation between sexes and validation of rodent studies in higher order species. The current study
Axon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses.
Teliska, et al.
The Journal of Neuroscience, 42, 8054-8065 (2023)
Jonathan Madar et al.
Nature communications, 14(1), 2158-2158 (2023-04-16)
The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity in a sex dependent manner. Clozapine N-oxide-induced activation
Peter Podbevšek et al.
Scientific reports, 8(1), 3189-3189 (2018-02-18)
Pervasive transcription of mammalian genomes leads to a previously underestimated level of complexity in gene regulatory networks. Recently, we have identified a new functional class of natural and synthetic antisense long non-coding RNAs (lncRNA) that increases translation of partially overlapping
Daniela M Menichella et al.
Molecular pain, 12 (2016-09-04)
Small fiber neuropathy is a well-recognized complication of type 2 diabetes and has been shown to be responsible for both neuropathic pain and impaired wound healing. In previous studies, we have demonstrated that ganglioside GM3 depletion by knockdown of GM3
Chiara Traini et al.
Journal of cellular and molecular medicine, 23(6), 4076-4087 (2019-04-05)
Urothelium and Lamina Propria (LP) are considered an integrate sensory system which is able to control the detrusor activity. Complete supra-sacral spinal cord lesions cause Neurogenic Detrusor Overactivity (NDO) whose main symptoms are urgency and incontinence. NDO therapy at first
Maximilian I Pinkham et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 312(3), R368-R379 (2017-01-06)
Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery
Shivani Ghaisas et al.
Environmental health perspectives, 129(8), 87005-87005 (2021-08-20)
Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) have yet to be assessed. We examined the effect of Mn on the ENS
Jung-Eun Choi et al.
Molecular & cellular proteomics : MCP, 17(9), 1803-1823 (2018-07-01)
Chronic physical restraint stress increases oxidative stress in the brain, and dysregulation of oxidative stress can be one of the causes of major depressive disorder. To understand the underlying mechanisms, we undertook a systematic proteomic analysis of hippocampus in a
Karen A Lindquist et al.
eNeuro, 8(5) (2021-09-29)
Understanding masseter muscle (MM) innervation is critical for the study of cell-specific mechanisms of pain induced by temporomandibular disorder (TMDs) or after facial surgery. Here, we identified trigeminal (TG) sensory neuronal subtypes (MM TG neurons) innervating MM fibers, masseteric fascia
Rashmi Chandra et al.
JCI insight, 8(23) (2023-12-08)
Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson's disease. Although past experimental studies in mouse models have relied on gut injections of
Becky J Proskocil et al.
Journal of neuroinflammation, 18(1), 209-209 (2021-09-18)
Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7 agonists also modulate sensory nerve function by increasing neuronal excitability, although
Shivani Ghaisas et al.
Neurotoxicology, 75, 186-199 (2019-09-11)
Gastrointestinal (GI) disturbances are one of the earliest symptoms affecting most patients with Parkinson's disease (PD). In many cases, these symptoms are observed years before motor impairments become apparent. Hence, the molecular and cellular underpinnings that contribute to this early
Jacob T Boyd et al.
Nature metabolism, 3(6), 762-773 (2021-06-19)
Chronic pain is the leading cause of disability worldwide1 and is commonly associated with comorbid disorders2. However, the role of diet in chronic pain is poorly understood. Of particular interest is the Western-style diet, enriched with ω-6 polyunsaturated fatty acids
Alexandra B Pincus et al.
Scientific reports, 12(1), 5006-5006 (2022-03-25)
We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulations did not form intraganglionic interneurons, but rather, extended outside the ganglia, into the airways
Baoyan Fan et al.
Diabetologia, 63(2), 431-443 (2019-11-20)
Diabetic peripheral neuropathy (DPN) is one of the major complications of diabetes, which contributes greatly to morbidity and mortality. There is currently no effective treatment for this disease. Exosomes are cell-derived nanovesicles and play an important role in intercellular communications.
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