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Showing 1-30 of 251 results for "AB2302" within Papers
Balazs Veres et al.
FEBS open bio, 11(3), 684-704 (2021-01-21)
Microorganisms or LPS (lipopolysaccharide), an outer membrane component of Gram-negative bacteria, can induce a systemic inflammatory response that leads to sepsis, multiple organ dysfunction, and mortality. Here, we investigated the role of cyclophilin D (CypD)-dependent mitochondrial permeability transition (mPT) in
Qian Bu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(13), 3671-3685 (2017-03-09)
Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene. To facilitate the study of cellular mechanisms in human cells, we established several human stem cell lines: human embryonic stem cell (hESC) line carrying the
Zhixiang Xu et al.
PloS one, 8(5), e63598-e63598 (2013-05-10)
Glycogen synthase kinase 3β (GSK3β), a multifaceted kinase, is abundantly expressed in the brain, including the olfactory bulb (OB). In resting cells, GSK3β is constitutively active, and its over-activation is presumably involved in numerous brain diseases, such as Alzheimer's disease.
Rupali Sharma et al.
Scientific reports, 9(1), 16406-16406 (2019-11-13)
Long-term operations carried out at high altitude (HA) by military personnel, pilots, and astronauts may trigger health complications. In particular, chronic exposure to high altitude (CEHA) has been associated with deficits in cognitive function. In this study, we found that
Robyn A Umans et al.
Cancers, 13(24) (2021-12-25)
Glioblastoma multiforme (GBM) is a deadly brain tumor with a large unmet therapeutic need. Here, we tested the hypothesis that wild-type p53 is a negative transcriptional regulator of SLC7A11, the gene encoding the System xc- (SXC) catalytic subunit, xCT, in
Laura Satterfield et al.
International journal of cancer, 141(10), 2062-2075 (2017-07-28)
Ewing Sarcoma (ES) is a highly aggressive bone tumor with peak incidence in the adolescent population. It has a high propensity to metastasize, which is associated with dismal survival rates of approximately 25%. To further understand mechanisms of metastasis we
Chun-Chun Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(21), 5946-5951 (2016-05-11)
Multifunctional β-catenin, with critical roles in both cell-cell adhesion and Wnt-signaling pathways, was among HeLa cell proteins coimmunoprecipitated by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG2) that activate ADP-ribosylation factors (Arfs) by accelerating the
Ria Thomas et al.
Molecular brain, 14(1), 16-16 (2021-01-21)
Lysosomal dysfunction is a central pathway associated with Parkinson's disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest genetic risk factors for developing PD. Deficiencies in the activity of the GCase enzyme
Wenjuan Song et al.
Foods (Basel, Switzerland), 11(21) (2022-11-12)
Cultured meat is an innovative meat-production technology that does not rely on animal husbandry. As a new food component, cultured fat is of great significance to cultured meat. In this study, we isolated adipose-derived stem cells (ADSCs) and identified the
Lyndsay Murrow et al.
Nature cell biology, 17(3), 300-310 (2015-02-17)
The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12-ATG3 have impaired basal
Yaxing Gui et al.
Brain pathology (Zurich, Switzerland), 30(1), 151-164 (2019-07-06)
The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging radioligands, but its expression in post-mortem normal and diseased human brain is not well described. We aimed at characterizing the TSPO expression in human control
Francesca Lazzara et al.
Journal of neuroinflammation, 18(1), 206-206 (2021-09-18)
Glaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible vision loss. Neuroinflammation is recognized as one of the causes of glaucoma, and currently no treatment is addressing this mechanism.
Benjamin E Clarke et al.
Cell stress & chaperones, 24(5), 857-870 (2019-06-07)
Preferential neuronal vulnerability is characteristic of several neurodegenerative diseases including the motor neuron disease amyotrophic lateral sclerosis (ALS). It is well established that glia play a critical role in ALS, but it is unknown whether regional differences in the ability
Francesca Di Cristo et al.
Journal of cellular physiology, 234(6), 9233-9246 (2018-10-27)
Mitochondrial dysfunction seems to play a fundamental role in the pathogenesis of neurodegeneration in Huntington's disease (HD). We assessed possible neuroprotective actions of meldonium, a small molecule affecting mitochondrial fuel metabolism, in in vitro and in vivo HD models. We
Sabrina Spiller et al.
Pharmaceutics, 13(10) (2021-10-24)
Biomaterials are designed to improve impaired healing of injured tissue. To accomplish better cell integration, we suggest to coat biomaterial surfaces with bio-functional proteins. Here, a mussel-derived surface-binding peptide is used and coupled to CXCL12 (stromal cell-derived factor 1α), a
Agata Wrońska et al.
International journal of molecular sciences, 25(5) (2024-03-13)
We investigated the age-related effects of the lipid-lowering drug fenofibrate on renal stress-associated effectors. Young and old rats were fed standard chow with 0.1% or 0.5% fenofibrate. The kidney cortex tissue structure showed typical aging-related changes. In old rats, 0.1%
Mariya V Hrynchak et al.
Frontiers in synaptic neuroscience, 12, 16-16 (2020-05-12)
Alzheimer's disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligomeric amyloid-β (Aβ) is thought to play a causative role in this disease, which eventually leads to cognitive decline. However, most animal studies have employed mice expressing
Ajay Dixit et al.
American journal of physiology. Gastrointestinal and liver physiology, 317(4), G463-G475 (2019-08-23)
In the current study, we explored the role of extracellular ATP (eATP) in promoting systemic inflammation during development of acute pancreatitis (AP). Release of extracellular (e)ATP was evaluated in plasma and bronchoalveolar lavage fluid (BALF) of mice with experimental acute
Eric Peter Thelin et al.
Frontiers in neurology, 7, 23-23 (2016-03-26)
Hypoxia following traumatic brain injury (TBI) is a severe insult shown to exacerbate the pathophysiology, resulting in worse outcome. The aim of this study was to investigate the effects of a hypoxic insult in a focal TBI model by monitoring
Robyn A Umans et al.
Frontiers in cell and developmental biology, 9, 654338-654338 (2021-07-17)
An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are best studied in vivo and great
Arinjay Banerjee et al.
Scientific reports, 10(1), 7257-7257 (2020-05-01)
Coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are speculated to have originated in bats. The mechanisms by which these viruses are maintained in individuals or populations of reservoir bats remain an enigma. Mathematical
Dimitri Traenkner et al.
eNeuro, 10(12) (2023-11-18)
Kirrel3 is a cell-adhesion molecule that instructs the formation of specific synapses during brain development in mouse and Kirrel3 variants may be risk factors for autism and intellectual disabilities in humans. Kirrel3 is predicted to undergo alternative splicing but brain
Hayato Urushima et al.
American journal of physiology. Gastrointestinal and liver physiology, 324(3), G219-G230 (2023-02-01)
In cirrhosis, several molecular alterations such as resistance to apoptosis could accelerate carcinogenesis. Recently, mechanotransduction has been attracting attention as one of the causes of these disturbances. In patients with cirrhosis, the serum sodium levels progressively decrease in the later
Benjamin J Solomon et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 15(4), 541-549 (2020-01-29)
Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented efficacy in tumors positive for RET fusions or mutations, notably RET fusion-positive NSCLC and RET-mutated medullary thyroid cancer (MTC). However, the mechanisms of resistance
Penelope J Hallett et al.
Neurobiology of aging, 67, 189-200 (2018-05-08)
Aging is the predominant risk factor for both genetic and sporadic Parkinson's disease (PD). The majority of PD cases are nonfamilial, and the connection between aging and PD-associated genes is not well understood. Haploinsufficiency of the GBA gene, leading to
Han Zhao et al.
Brain and behavior, 8(7), e01004-e01004 (2018-06-02)
It is known that an interruption of acoustic input in early life will result in abnormal development of the auditory system. Here, we further show that this negative impact actually spans beyond the auditory system to the hippocampus, a system
Joanna A Korecka et al.
Molecular therapy. Nucleic acids, 21, 623-635 (2020-08-01)
Parkinson's disease (PD) is a progressive neurological disorder estimated to affect 7-10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity has been associated with genetic
Yohei Hayashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), 13057-13062 (2016-10-30)
Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent
Adrian Zubrzycki et al.
Acta biochimica Polonica, 70(2), 285-293 (2023-04-07)
Sirtuin 1 (Sirt1) and sirtuin 3 (Sirt3) participate in the regulation of lipid metabolism. Our aim was to investigate the effects of the hypolipemic drug fenofibrate (FN) on hepatic Sirt1 and Sirt3 expression, in relation to the expression of lipid
Sunyoung Hwang et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(6) (2021-02-03)
An extra copy of chromosome 21 causes Down syndrome, the most common genetic disease in humans. The mechanisms contributing to aneuploidy-related pathologies in this syndrome, independent of the identity of the triplicated genes, are not well defined. To characterize aneuploidy-driven
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