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Showing 1-30 of 229 results for "AB3623" within Papers
Jéssica C C G Ferreira et al.
Disease models & mechanisms, 17(2) (2024-02-28)
The Zika virus received significant attention in 2016, following a declaration by the World Health Organization of an epidemic in the Americas, in which infections were associated with microcephaly. Indeed, prenatal Zika virus infection is detrimental to fetal neural stem
VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development.
Sung, et al.
eLife, 11 (2022)
Estela Lorza-Gil et al.
Journal of cellular physiology, 234(7), 11047-11059 (2018-12-12)
New onset of diabetes is associated with the use of statins. We have recently demonstrated that pravastatin-treated hypercholesterolemic LDL receptor knockout (LDLr-/- ) mice exhibit reductions in insulin secretion and increased islet cell death and oxidative stress. Here, we hypothesized that
N V Srikanth Vallabani et al.
Mutagenesis, 34(3), 265-277 (2019-07-05)
Zinc oxide nanoparticles (ZnO NPs) with their wide range of consumer applications in day-to-day life received great attention to evaluate their effects in humans. This study has been attempted to elucidate the DNA damage response mechanism in a dermal model
Ashley L Alvers et al.
Development (Cambridge, England), 141(5), 1110-1119 (2014-02-08)
The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro, their function during vertebrate organogenesis is poorly understood.
Mohammad M Al-Sanea et al.
Journal of enzyme inhibition and medicinal chemistry, 38(1), 2166936-2166936 (2023-02-03)
Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. Derivatives 3b and 8b showed the
Xue-Jun Cheng et al.
World journal of stem cells, 12(11), 1354-1365 (2020-12-15)
As the third most abundant element, aluminum is widespread in the environment. Previous studies have shown that aluminum has a neurotoxic effect and its exposure can impair neuronal development and cognitive function. To study the effects of aluminum on epigenetic
Efthymia Papaevangelou et al.
Frontiers in immunology, 14, 1196829-1196829 (2023-07-19)
Prostate cancer is one of the most commonly diagnosed malignancies in men with high mortality rates. Despite the recent therapeutic advances, such as immunotherapies, survival of patients with advance disease remains significantly low. Blockade of immune checkpoints has led to
Daniela A Gutierrez et al.
Frontiers in cellular neuroscience, 13, 526-526 (2019-12-19)
Spine pathology has been implicated in the early onset of Alzheimer's disease (AD), where Aβ-Oligomers (AβOs) cause synaptic dysfunction and loss. Previously, we described that pharmacological inhibition of c-Abl prevents AβOs-induced synaptic alterations. Hence, this kinase seems to be a
Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
Zhang, et al.
Neuron, 110, 992-1008 (2023)
Edel Hennessy et al.
Brain, behavior, and immunity, 59, 233-244 (2016-09-17)
Inflammation influences chronic neurodegeneration but its precise roles are not yet clear. Systemic inflammation caused by infection, trauma or co-morbidity can alter the brain's inflammatory status, produce acute cognitive impairments, such as delirium, and drive new pathology and accelerated decline.
Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model.
Tarang, S; Doi, SM; Gurumurthy, CB; Harms, D; Quadros, R; Rocha-Sanchez, SM
Frontiers in Cellular Neuroscience null
Monika E Dolega et al.
PloS one, 9(6), e99416-e99416 (2014-06-20)
We present a simple bench-top method to fabricate enclosed circular channels for biological experiments. Fabricating the channels takes less than 2 hours by using glass capillaries of various diameters (from 100 µm up to 400 µm) as a mould in
Shan Wang et al.
Cell research, 19(12), 1350-1362 (2009-09-30)
Cytotoxic lymphocytes are key players in the orchestration of immune response and elimination of defective cells. We have previously reported that natural killer (NK) cells enter target tumor cells, leading to either target cell death or self-destruction within tumor cells.
Liansheng Zhang et al.
STAR protocols, 2(4), 100915-100915 (2021-11-11)
Neuronal loss resulting from progressive neurodegeneration is a major pathological feature of Alzheimer's disease (AD). Here, we present a protocol to detect neurodegeneration, neuronal apoptosis, and neuronal loss in 5XFAD mouse strain, which is a well-established model for interrogating the
Kara Goodkey et al.
BMC medicine, 22(1), 158-158 (2024-04-15)
ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cortical neurogenesis. Here, we show a novel olfactory bulb phenotype
Diana Alejandra Quintero-Espinosa et al.
International journal of molecular sciences, 24(21) (2023-11-14)
Several efforts to develop new protocols to differentiate in in vitro human mesenchymal stromal cells (hMSCs) into dopamine (DA) neurons have been reported. We have formulated NeuroForsk 2.0 medium containing fibroblast growth factor type beta (FGFb), brain-derived neurotrophic factor (BDNF)
Filippo Ghezzi et al.
eLife, 10 (2021-07-13)
Subplate neurons (SPNs) are thought to play a role in nascent sensory processing in neocortex. To better understand how heterogeneity within this population relates to emergent function, we investigated the synaptic connectivity of Lpar1-EGFP SPNs through the first postnatal week
Lara Buscemi et al.
Cerebral cortex (New York, N.Y. : 1991), 27(3), 2365-2384 (2016-04-15)
In astrocytes, the intracellular calcium (Ca2+) signaling mediated by activation of metabotropic glutamate receptor 5 (mGlu5) is crucially involved in the modulation of many aspects of brain physiology, including gliotransmission. Here, we find that the mGlu5-mediated Ca2+ signaling leading to
Niki Ktena et al.
Cell stress, 6(12), 93-107 (2022-12-09)
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates. Although a few studies implicate autophagy in CNS demyelinating pathologies, its role, particularly in mature oligodendrocytes and CNS
The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome.
Dos Santos, et al.
Pharmaceutics, 15 (2023)
Ilaria Piano et al.
Scientific reports, 13(1), 20138-20138 (2023-11-18)
Microglia chronic activation is a hallmark of several neurodegenerative diseases, including the retinal ones, possibly contributing to their etiopathogenesis. However, some microglia sub-populations have anti-inflammatory and neuroprotective functions, thus making arduous deciphering the role of these cells in neurodegeneration. Since
Daniel B L Teh et al.
Development, growth & differentiation, 56(8), 583-594 (2014-10-07)
In the adult hippocampus, new neurons are continuously generated and incorporated into the local circuitry in a manner dependent on the network activity. Depolarization evoked by neurotransmitters has been assumed to activate L-type Ca2+ channels (LTCC) which regulate the intracellular
Tawna L Mangosh et al.
Molecular cancer research : MCR, 19(2), 301-316 (2020-11-15)
In advanced prostate cancer, resistance to androgen deprivation therapy is achieved through numerous mechanisms, including loss of the androgen receptor (AR) allowing for AR-independent growth. Therapeutic options are limited for AR-independent castration-resistant prostate cancer (CRPC), and defining mechanisms critical for
Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus.
Poser, R; Dokter, M; von Bohlen Und Halbach, V; Berger, SM; Busch, R; Baldus, M; Unsicker et al.
Frontiers in Neuroanatomy null
K R Francis et al.
Cell death & disease, 1, e22-e22 (2011-03-03)
Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a
Mei Xiang et al.
Journal of neurochemistry, 129(6), 988-1001 (2014-02-18)
Interferon regulatory factor 8 (IRF8), a transcriptional regulator in the IRF family, has been implicated in innate immunity, immune cell differentiation and tumour cell apoptosis. In the present study, we found that IRF8 is constitutively expressed in the brain and
G Berdugo-Vega et al.
Journal of anatomy, 225(5), 492-501 (2014-09-03)
Changes that occur in astroglial populations of the nucleus ambiguus after recurrent (RLN) or superior (SLN) laryngeal nerve injury have hitherto not been fully characterised. In the present study, rat RLN and SLN were lesioned. After 3, 7, 14, 28
Rachael Mooney et al.
Stem cells international, 2018, 7047496-7047496 (2018-07-22)
Tumor-tropic neural stem cells (NSCs) can be engineered to localize gene therapies to invasive brain tumors. However, like other stem cell-based therapies, survival of therapeutic NSCs after transplantation is currently suboptimal. One approach to prolonging cell survival is to transiently
Understanding Primary Blast Injury: High Frequency Pressure Acutely Disrupts Neuronal Network Dynamics in Cerebral Organoids.
Silvosa, et al.
Journal of Neurotrauma, 39, 1575-1590 (2022)
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