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Showing 1-30 of 73 results for "AB5220" within Papers
Gerburg Keilhoff et al.
Experimental and therapeutic medicine, 11(5), 1685-1699 (2016-05-12)
The present study was conducted to investigate the effects of minocycline on the expression of selected transcriptional and translational profiles in the rat spinal cord following sciatic nerve (SNR) transection and microsurgical coaptation. The mRNA and protein expression levels of
Christopher H Ferguson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(1), 110-119 (2017-01-06)
In vertebrate olfactory sensory neurons (OSNs), Ca2+ plays key roles in both mediating and regulating the olfactory response. Ca2+ enters OSN cilia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chloride current by opening
José Antonio de Mera-Rodríguez et al.
Cells, 11(2) (2022-01-22)
The histochemical detection of β-galactosidase enzymatic activity at pH 6.0 (β-gal-pH6) is a widely used biomarker of cellular senescence in aging tissues. This histochemical assay also detects the presence of programmed cell senescence during specific time windows in degenerating structures
Jie Su et al.
The Journal of comparative neurology, 523(10), 1505-1528 (2015-01-30)
The mechanisms underlying rheumatoid arthritis (RA)-induced pain are still not fully elucidated, and accumulating data indicate that peripheral inflammation is not the only factor driving pain in these patients. The focus of our work is to investigate the molecular basis
Tuan Nguyen et al.
The Journal of biological chemistry, 284(28), 18816-18823 (2009-05-16)
Transcription is essential for neurite and axon outgrowth during development. Recent work points to the involvement of nuclear factor of activated T cells (NFAT) in the regulation of genes important for axon growth and guidance. However, NFAT has not been
Dmitry Shvartsman et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1243-1253 (2014-04-29)
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance
Denis Depes et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 70(9), 627-642 (2022-09-27)
Myocardial sleeves around pulmonary veins (PVs) are highly innervated structures with heterogeneous morphological and electrophysiological characteristics. Autonomic nerve dysfunction in the myocardium may be associated with an increased risk of cardiovascular morbidity and mortality. This article studied autonomic neural remodeling
Tomohiro Kurisaki et al.
FEBS letters, 532(3), 419-422 (2002-12-17)
Meltrin beta (ADAM19) is a metalloprotease-disintegrin expressed in the peripheral nervous system and other organs during embryogenesis. We report here an alternatively spliced isoform, meltrin beta mini, that lacks the prodomain, metalloprotease and disintegrin domains. A comparison of the cDNA
Marta Diaz-delCastillo et al.
JBMR plus, 4(2), e10252-e10252 (2020-02-23)
Bone pain is a serious and debilitating symptom of multiple myeloma (MM) that impairs the quality of life of patients. The underlying mechanisms of the pain are unknown and understudied, and there is a need for immunocompetent preclinical models of
Andrea Raspa et al.
CNS neuroscience & therapeutics, 25(1), 86-100 (2018-06-02)
Usually, spinal cord injury (SCI) develops into a glial scar containing extracellular matrix molecules including chondroitin sulfate proteoglycans (CSPGs). Chondroitinase ABC (ChABC), from Proteus vulgaris degrading the glycosaminoglycan (GAG) side chains of CSPGs, offers the opportunity to improve the final
Cristina Roselló-Busquets et al.
Frontiers in cellular neuroscience, 13, 40-40 (2019-02-28)
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. Cholesterol is a component of membrane rafts
Owein Guillemot-Legris et al.
International journal of molecular sciences, 24(15) (2023-08-12)
Peripheral nerve injuries are quite common and often require a surgical intervention. However, even after surgery, patients do not often regain satisfactory sensory and motor functions. This, in turn, results in a heavy socioeconomic burden. To some extent, neurons can
Tasuku Nishihara et al.
The Journal of biological chemistry, 290(6), 3693-3707 (2014-12-10)
Neuronal glial antigen 2 (NG2) is an integral membrane chondroitin sulfate proteoglycan expressed by vascular pericytes, macrophages (NG2-Mφ), and progenitor glia of the nervous system. Herein, we revealed that NG2 shedding and axonal growth, either independently or jointly, depended on
Martin Teichert et al.
Nature communications, 8, 16106-16106 (2017-07-19)
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled
Homero L Cantu-Guerra et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 252(1), 124-144 (2022-10-27)
Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is necessary for conveying sound information to the brain in mammals. Previous studies have shown that type I SGNs are heterogeneous in form
Emiliano Peña-Altamira et al.
The European journal of neuroscience, 39(2), 176-185 (2014-01-21)
CCAAT enhancer-binding protein β is a transcription factor that is involved in many brain processes, although its role in neuronal survival/death remains unclear. By using primary cultures of rat cerebellar granule neurons, we have shown here that CCAAT enhancer-binding protein
Patricia Bock et al.
Brain pathology (Zurich, Switzerland), 23(1), 82-99 (2012-07-19)
Spinal cord injury (SCI) represents a devastating central nervous system disease that still lacks sufficient therapies. Here, dogs are increasingly recognized as a preclinical animal model for the development of future therapies. The aim of this study was a detailed
Jun Yu et al.
Nucleic acids research, 46(3), 1412-1423 (2017-12-01)
N6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known. Here, we found that the m6A eraser
Iwa Lee et al.
Neurotoxicology, 37, 190-196 (2013-05-25)
Perfluorohexane sulfonate (PFHxS) is an industrial chemical and belongs to the group of perfluorinated compounds (PFCs). It has recently been shown to cause developmental neurobehavioral defects in mammals. These compounds are commonly used in products such as surfactant and protective
Guangfan Zhang et al.
eNeuro, 3(5) (2016-11-09)
A developmental program of epigenetic repression prepares each mammalian olfactory sensory neuron (OSN) to strongly express one allele from just one of hundreds of odorant receptor (OR) genes, but what completes this process of OR gene choice by driving the
Zong-Yi Zhan et al.
Neural regeneration research, 18(4), 913-921 (2022-10-08)
Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve regeneration. However, morphological assessments of retinorecipient regions are limited by the opacity of brain tissue. In this study, we used an
Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.
Hirata, T; Nakazawa, M; Yoshihara, S; Miyachi, H; Kitamura, K; Yoshihara, Y; Hibi, M
Development null
Bruno Siqueira Mietto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(50), 16431-16442 (2015-12-18)
A rapid proinflammatory response after peripheral nerve injury is required for clearance of tissue debris (Wallerian degeneration) and effective regeneration. Unlike the CNS, this response is rapidly terminated in peripheral nerves starting between 2 and 3 weeks after crush injury.
Cheng-Che Lee et al.
Journal of cardiovascular pharmacology, 77(6), 745-755 (2021-06-01)
The NLRP3 inflammasome is activated by myocardial infarction and then induces the activation of inflammatory caspase-1 activation and maturation of IL-1β, a regulator of synthesis of the nerve growth factor (NGF). Here, we studied whether taurine, 2-aminoethanesulphonic acid, can attenuate
Shahabeddin Vahdat et al.
Science advances, 7(33) (2021-08-13)
Poststroke optogenetic stimulations can promote functional recovery. However, the circuit mechanisms underlying recovery remain unclear. Elucidating key neural circuits involved in recovery will be invaluable for translating neuromodulation strategies after stroke. Here, we used optogenetic functional magnetic resonance imaging to
Zhirong Wang et al.
eNeuro, 7(4) (2020-07-18)
The mammalian cochlea undergoes a highly dynamic process of growth and innervation during development. This process includes spiral ganglion neuron (SGN) branch refinement, a process whereby Type I SGNs undergo a phase of "debranching" before forming unramified synaptic contacts with
Aaron P Bloom et al.
The journal of pain : official journal of the American Pain Society, 12(6), 698-711 (2011-04-19)
Breast cancer metastasis to bone is frequently accompanied by pain. What remains unclear is why this pain tends to become more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve
A Gärtner et al.
Differentiation; research in biological diversity, 84(5), 355-365 (2012-11-13)
Cellular systems implanted into an injured nerve may produce growth factors or extracellular matrix molecules, modulate the inflammatory process and eventually improve nerve regeneration. In the present study, we evaluated the therapeutic value of human umbilical cord matrix MSCs (HMSCs)
Gigi J Ebenezer et al.
Experimental neurology, 352, 114053-114053 (2022-03-29)
Nine-banded armadillos develop peripheral neuropathy after experimental Mycobacterium leprae infection that recapitulates human disease. We used an intracutaneous excision axotomy model to assess the effect of infection duration by M. leprae on axonal sprouting and Schwan cell density. 34 armadillos
Peter U Hámor et al.
Neuroscience, 443, 93-109 (2020-06-17)
The central nucleus of the amygdala (CeA) is a striatum-like structure that contains mainly inhibitory circuits controlling a repertoire of (mal)adaptive behaviors related to pain, anxiety, motivation, and addiction. Neural activity in the CeA is also necessary for the expression
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