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Showing 1-30 of 103 results for "AB947" within Papers
Mariana Aparecida Brunini Rosales et al.
Life science alliance, 2(3) (2019-05-19)
The retinal pigment epithelium (RPE) supports visual processing and photoreceptor homeostasis via energetically demanding cellular functions. Here, we describe the consequences of repressing peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α), a master regulator of mitochondrial function and biogenesis, on RPE
Antonino Asaro et al.
Journal of cell science, 134(20) (2021-09-25)
Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with the apoE3 variant but
Ronald D Gorham et al.
Journal of medicinal chemistry, 58(2), 814-826 (2014-12-11)
Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W4A9 sequence (Ac-ICVWQDWGAHRCT-NH2
Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium.
??lvarez-Barrios, et al.
Frontiers in nutrition, 10, 1124987-1124987 (2023)
Yannick Tréguier et al.
Virology journal, 19(1), 124-124 (2022-07-29)
Zika virus (ZIKV), a member of the Flaviviridae family, has caused massive outbreaks of infection in tropical areas over the last decade and has now begun spreading to temperate countries. Little is currently known about the specific host factors involved
Differential regulation of amyloid-? endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
Li, J; Kanekiyo, T; Shinohara, M; Zhang, Y; LaDu, MJ; Xu, H; Bu, G
The Journal of Biological Chemistry null
Elsa Gomez-Escobar et al.
Scientific reports, 11(1), 21856-21856 (2021-11-10)
Hepatitis C is a major threat to public health for which an effective treatment is available, but a prophylactic vaccine is still needed to control this disease. We designed a vaccine based on chimeric HBV-HCV envelope proteins forming subviral particles
Matthew G Pilgrim et al.
Investigative ophthalmology & visual science, 58(2), 708-719 (2017-02-02)
Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD. We examined whether cultured RPE cells could produce extracellular
M Valenza et al.
Cell death and differentiation, 22(4), 690-702 (2014-10-11)
In the adult brain, neurons require local cholesterol production, which is supplied by astrocytes through apoE-containing lipoproteins. In Huntington's disease (HD), such cholesterol biosynthesis in the brain is severely reduced. Here we show that this defect, occurring in astrocytes, is
Claudia Tonini et al.
Nutrients, 13(1) (2021-01-21)
A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging
Kannan V Manian et al.
Cell stem cell, 28(5), 846-862 (2021-03-31)
The retinal pigment epithelium (RPE)-choriocapillaris (CC) complex in the eye is compromised in age-related macular degeneration (AMD) and related macular dystrophies (MDs), yet in vitro models of RPE-CC complex that enable investigation of AMD/MD pathophysiology are lacking. By incorporating iPSC-derived cells
Qitao Zhang et al.
Aging, 13(8), 10866-10890 (2021-04-20)
Dry age-related macular degeneration (AMD) is marked by the accumulation of extracellular and intracellular lipid-rich deposits within and around the retinal pigment epithelium (RPE). Inducing autophagy, a conserved, intracellular degradative pathway, is a potential treatment strategy to prevent disease by
Priyanka Narayan et al.
Cell reports, 33(1), 108224-108224 (2020-10-08)
The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer's disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocytic defect in APOE4 astrocytes compared with
Constantin N Takacs et al.
Traffic (Copenhagen, Denmark), 18(3), 192-204 (2016-12-31)
Apolipoprotein E (ApoE), a component of very-low-density and high-density lipoproteins, participates in many aspects of lipid transport in the bloodstream. Underscoring its important functions, ApoE isoforms have been associated with metabolic and circulatory disease. ApoE is also incorporated into hepatitis
Seong Su Kang et al.
Acta neuropathologica, 142(1), 139-158 (2021-04-26)
ApoE4 enhances Tau neurotoxicity and promotes the early onset of AD. Pretangle Tau in the noradrenergic locus coeruleus (LC) is the earliest detectable AD-like pathology in the human brain. However, a direct relationship between ApoE4 and Tau in the LC
Sara Calattini et al.
The Journal of biological chemistry, 290(38), 23173-23187 (2015-08-01)
Lipoprotein components are crucial factors for hepatitis C virus (HCV) assembly and entry. As hepatoma cells producing cell culture-derived HCV (HCVcc) particles are impaired in some aspects of lipoprotein metabolism, it is of upmost interest to biochemically and functionally characterize
Lucie Fénéant et al.
Journal of virology, 89(16), 8346-8364 (2015-06-05)
In our study, we characterized the effect of monensin, an ionophore that is known to raise the intracellular pH, on the hepatitis C virus (HCV) life cycle. We showed that monensin inhibits HCV entry in a pangenotypic and dose-dependent manner.
Kiyoharu J Miyagishima et al.
Communications biology, 4(1), 1360-1360 (2021-12-11)
Late-onset retinal degeneration (L-ORD) is an autosomal dominant disorder caused by a missense substitution in CTRP5. Distinctive clinical features include sub-retinal pigment epithelium (RPE) deposits, choroidal neovascularization, and RPE atrophy. In induced pluripotent stem cells-derived RPE from L-ORD patients (L-ORD-iRPE)
Fatemeh Nouri Emamzadeh et al.
Journal of molecular neuroscience : MN, 63(2), 165-172 (2017-09-10)
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by dopaminergic neural cell death in the substantia nigra of the brain and α-synuclein (α-syn) accumulation in Lewy bodies. α-Syn can be detected in blood and is a potential biomarker for
Nilsson, LN; Gografe, S; Costa, DA; Hughes, T; Dressler, D; Potter, H
Technology and innovation null
Saima I Machlovi et al.
Neurobiology of disease, 164, 105615-105615 (2022-01-16)
Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of
Emily J Koller et al.
Molecular neurobiology, 57(4), 1986-2001 (2020-01-07)
Apolipoprotein E4 (APOE4) is the major genetic risk factor for sporadic Alzheimer's disease (AD), which is characterized by amyloid β (Aβ) plaques and tau tangles. Though the role of APOE4 in Aβ pathogenesis has been mechanistically defined in rodent models
Frauke Beilstein et al.
Gut, 66(12), 2160-2169 (2016-09-02)
HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due
Irene Anastasia et al.
Cell reports, 34(11), 108873-108873 (2021-03-18)
Contacts between organelles create microdomains that play major roles in regulating key intracellular activities and signaling pathways, but whether they also regulate systemic functions remains unknown. Here, we report the ultrastructural organization and dynamics of the inter-organellar contact established by
Chia-Chen Liu et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 16(10), 1372-1383 (2020-08-23)
Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood-brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer's disease (AD) cases. We performed neuropathologic and biochemical studies on a large, neuropathologically confirmed human AD cohort (N = 469).
A M Schonhoff et al.
Nature communications, 14(1), 3754-3754 (2023-06-27)
Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of central nervous system (CNS) resident macrophages
Eleanna Kara et al.
The Journal of biological chemistry, 292(36), 14720-14729 (2017-07-08)
Apolipoprotein E (apoE) has an important role in the pathogenesis of Alzheimer's disease with its three isoforms having distinct effects on disease risk. Here, we assessed the conformational differences between those isoforms using a novel flow cytometry-Forster resonance energy transfer
Eleanna Kara et al.
The Journal of biological chemistry, 293(34), 13247-13256 (2018-06-29)
Apolipoprotein E (ApoE) is a secreted apolipoprotein with three isoforms, E2, E3, and E4, that binds to lipids and facilitates their transport in the extracellular environment of the brain and the periphery. The E4 allele is a major genetic risk
Qifei Cong et al.
Nature neuroscience, 23(9), 1067-1078 (2020-07-15)
Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination remains unknown. Here, we show that the sushi domain protein SRPX2
Makoto Kurano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14655-14670 (2020-09-13)
Hepatobiliary cholesterol handling, mediated by Niemann-Pick C1-like 1 protein (NPC1L1) and ABCG5/8, is well-known to contribute to the homeostasis of cholesterol. We attempted to elucidate the impact of hepatobiliary cholesterol handling on the homeostasis of sphingolipids and lysophospholipids, especially sphingosine
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