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Showing 1-30 of 36 results for "AP132F" within Papers
A Sami Saribas et al.
Journal of cellular physiology, 233(3), 2343-2359 (2017-07-20)
Agnoprotein (Agno) is an important regulatory protein of JC virus (JCV), BK virus (BKV) and simian virus 40 (SV40) and these viruses are unable to replicate efficiently in the absence of this protein. Recent 3D-NMR structural data revealed that Agno
Huayang Wang et al.
Oncoimmunology, 5(4), e1122157-e1122157 (2016-05-04)
Tumor-infiltrated macrophages were potential targets of the immune therapy for patients with colon cancer. Colony stimulating factor 1 (CSF1) is a primary chemoattractant and functional regulator for macrophages, and therefore would be a feasible intervention for the macrophage-targeting therapeutics. However
Sean McCutcheon et al.
Cell adhesion & migration, 11(1), 1-12 (2016-01-09)
Central nervous system (CNS) cells cultured in vitro as neuroclusters are useful models of tissue regeneration and disease progression. However, the role of cluster formation and collective migration of these neuroclusters to external stimuli has been largely unstudied in vitro.
Wen-Haur Chao et al.
BMC complementary and alternative medicine, 18(1), 193-193 (2018-06-24)
Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to evaluate, in relation to retinal ischemia, protective effects and mechanisms of Dendrobium nobile Lindley (DNL)
Joshua J Souchek et al.
Molecular cancer therapeutics, 16(9), 1819-1830 (2017-06-16)
Taxane-based therapy provides a survival benefit in patients with metastatic prostate cancer, yet the median survival is less than 20 months in this setting due in part to taxane-associated resistance. Innovative strategies are required to overcome chemoresistance for improved patient
Jennifer Rico-Varela et al.
Cellular and molecular bioengineering, 8(4), 553-565 (2015-11-26)
Medulloblastoma (MB) is a malignant pediatric brain tumor known for its aggressive metastatic potential. Despite the well-documented migration of MB cells to other parts of the brain and spinal column, MB chemotaxis is poorly understood. Herein, we examined the in
Raquel Blazquez et al.
Oncogene, 41(46), 5008-5019 (2022-10-13)
Brain metastasis in breast cancer remains difficult to treat and its incidence is increasing. Therefore, the development of new therapies is of utmost clinical relevance. Recently, toll-like receptor (TLR) 4 was correlated with IL6 expression and poor prognosis in 1
Qunhua Bai et al.
Experimental and therapeutic medicine, 12(2), 1060-1066 (2016-07-23)
Parkinson's disease (PD) is the second most common neurodegenerative disorder, which is characterized by the hallmark feature of loss of dopaminergic neurons in the substantia nigra. Energy metabolic disorder is associated with the pathogenesis of PD; however, the development of
Katherine A Waugh et al.
Cell reports, 29(7), 1893-1908 (2019-11-14)
People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mechanisms driving this unique clinical profile await
Deep S Bhattacharya et al.
ACS biomaterials science & engineering, 6(6), 3585-3598 (2020-07-04)
Many targeting strategies can be employed to direct nanoparticles to tumors for imaging and therapy. However, tumors display a dynamic, heterogeneous microenvironment that undergoes spatiotemporal changes, including the expression of targetable cell-surface biomarkers. Here, we develop a nanoparticle system to
Chun-Chao Chang et al.
International journal of oncology, 60(6) (2022-04-14)
The chromosome segregation 1‑like (CSE1L) protein, which regulates cellular mitosis and apoptosis, was previously found to be overexpressed in colorectal cancer (CRC) cells harboring mutations. Therefore, regulating CSE1L expression may confer chemotherapeutic effects against CRC. The gut microflora can regulate
Xianrong Mao et al.
Journal of neurochemistry, 100(5), 1300-1314 (2007-02-24)
Sp-family transcription factors (Sp1, Sp3 and Sp4) contain a zinc-finger domain that binds to DNA sequences rich in G-C/T. As assayed by RT-PCR analysis of mRNA, western-blot analysis, immunofluorescence, and antibody-dependent "supershift" of DNA-binding assays, the prominent Sp-family factors in
Sangkyu Park et al.
Cell proliferation, 51(6), e12500-e12500 (2018-08-29)
The sonic hedgehog (Shh) signalling pathway has an important role in the maintenance of various stem cells and organogenesis during development. However, the effect of Shh in skin-derived precursors (SKPs), which have the capacity for multipotency and self-renewal, is not
Davor Caric et al.
International journal of molecular sciences, 22(3) (2021-02-06)
Hip osteoarthritis (HOA) is characterized by degradation of the cartilage and synovitis. However, the pathohistological effects of synovial tissue inflammation on HOA are not clear. The aim of this study was to evaluate the expression of iNOS, BCL-2 and MMP-9
Jung Won Bae et al.
Nature communications, 12(1), 4352-4352 (2021-07-18)
It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons-two major types of cortical excitatory neurons that
Yun-Bi Lu et al.
Journal of neurochemistry, 150(6), 723-737 (2019-07-04)
Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the salvage pathway of nicotinamide adenine dinucleotide synthesis. NAMPT can also be secreted and functions as a cytokine. We have previously shown that in the brain, NAMPT expression and secretion can be
Kévin Terretaz et al.
PLoS pathogens, 19(3), e1011211-e1011211 (2023-03-18)
Wolbachia are common bacteria among terrestrial arthropods. These endosymbionts transmitted through the female germline manipulate their host reproduction through several mechanisms whose most prevalent form called Cytoplasmic Incompatibility -CI- is a conditional sterility syndrome eventually favoring the infected progeny. Upon
M Espe et al.
SpringerPlus, 4, 658-658 (2015-11-07)
Hydrolyzed fish proteins (H-pro) contains high concentrations of free amino acids and low molecular peptides that potentially benefit health. The following study aimed to test whether the water soluble phase of H-pro could reduce apoptosis and inflammation in primary liver
Marko Ostojic et al.
International journal of molecular sciences, 22(12) (2021-07-03)
Synovitis of the knee synovium is proven to be a precursor of knee osteoarthritis (OA), leading to a radiologically advanced stage of the disease. This study was conducted to elucidate the expression pattern of different inflammatory factors-NF-kB, iNOS, and MMP-9
Maryam Sadeghi-Zadeh et al.
International journal of molecular and cellular medicine, 11(1), 78-87 (2022-11-19)
Degeneration of dopaminergic (DA) neurons in the substantia nigra is known as the main cause of Parkinson's disease (PD). Preventing the loss of DA neurons alongside the cell-replacement therapy have brought tremendous hope for the treatment of PD. For this
M E Yeager et al.
The European respiratory journal, 39(1), 104-111 (2011-06-28)
Chronic inflammation is an important component of the fibroproliferative changes that characterise pulmonary hypertensive vasculopathy. Fibrocytes contribute to tissue remodelling in settings of chronic inflammation, including animal models of pulmonary hypertension (PH). We sought to determine whether circulating fibrocytes were
Hui Tang et al.
Neurological research, 30(7), 751-760 (2008-05-24)
Angiotensin II can promote cell stress, and the expression of its AT1 receptor is characteristic of neuronal populations that die off in multiple systems atrophy and Parkinson's disease. To explore the possible significance of these facts, we undertook to: (1)
Szu-Yuan Wu et al.
Marine drugs, 18(3) (2020-03-04)
Radiation-induced fibrosis (RIF) occurs after radiation therapy in normal tissues due to excessive production and deposition of extracellular matrix proteins and collagen, possibly resulting in organ function impairment. This study investigates the effects of low-molecular-weight fucoidan (LMF) on irradiated NIH3T3
Bo Li et al.
Physiologia plantarum, 174(4), e13727-e13727 (2022-06-04)
DNA methylation and histone modification enable plants to rapidly adapt to adverse temperature stresses, including low temperature (LT) and high temperature (HT) stress. In this study, we conducted physiological, epigenetic, and transcriptomic analyses of barley seedlings grown under control (22°C)
Wayne Murrell et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(2), 496-515 (2005-03-23)
Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory
Bing Zhao et al.
Experimental and therapeutic medicine, 15(4), 3836-3846 (2018-03-23)
Ischemic stroke is a highly complex pathological process that is divided into acute, subacute and chronic phases. Paeonol is a biologically active natural product with a variety of pharmacological effects, including those on neuronal activity. However, the effects of paeonol
Danit Mechlovich et al.
The Journal of pharmacology and experimental therapeutics, 333(3), 874-882 (2010-03-20)
Increasing evidence suggests that oxidative stress (OS)-induced pancreatic beta-cell impairments is involved in diabetes and diabetic complications. Our group has recently synthesized two multifunctional nontoxic, lipophilic, iron-chelating drugs, 5-{N-methyl-N-propargylaminomethyl}-8-hydroxyquinoline (M30) and 5-{4-propargylpiperazin-1-ylmethyl}-8-hydroxyquinoline (HLA20), for the treatment of various OS-mediated pathogeneses.
Wei-Jing Gong et al.
Cancer science, 109(8), 2391-2400 (2018-06-22)
Metastasis is the main cause of lung cancer-related death. The tumor microenvironment greatly contributes to tumor metastasis. Resistin, mainly secreted by tumor-associated macrophages in tumor tissues, is a 12.5-kDa cysteine-rich secretory protein that is found at significantly higher levels in
Anna Li et al.
Molecular medicine reports, 24(6) (2021-10-06)
Recurrent spontaneous abortion (RSA) effects both the physical and mental health of women of reproductive age. Trophoblast dysfunction may result in RSA due to shallow placental implantation. The mechanisms underlying formyl peptide receptor 2 (FPR2) on the biological functions of trophoblasts
Shan Jiang et al.
Journal of inflammation research, 15, 363-379 (2022-01-27)
As a severe complication of sepsis, sepsis-associated encephalopathy (SAE) usually manifests as impaired learning and memory ability in survivors. Previous studies have reported that environmental enrichment (EE) can increase the learning and memory ability in different brain injury models. However
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