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Showing 1-30 of 182 results for "APOAF" within Papers
Jing Zou et al.
Annals of hematology, 91(6), 813-823 (2012-01-20)
Ex vivo expansion of hematopoietic stem cells (HSCs) depends on HSC self-renewing proliferation and functional maintenance, which can be negatively affected by HSC differentiation, apoptosis, and senescence. Therefore, inhibition of HSC senescence may promote HSC expansion. To test this hypothesis
Seth A Wander et al.
Cancer discovery, 10(8), 1174-1193 (2020-05-15)
Mechanisms driving resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+) breast cancer have not been clearly defined. Whole-exome sequencing of 59 tumors with CDK4/6i exposure revealed multiple candidate resistance mechanisms including RB1 loss, activating alterations in AKT1
Chuan Xiang et al.
Translational research : the journal of laboratory and clinical medicine, 193, 42-53 (2018-01-13)
Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular components to target cells, yet their function in disease is just being explored. However, the therapeutic effects of MVs in cartilage injury and degeneration remain unknown.
Xia Li et al.
Frontiers in immunology, 12, 758451-758451 (2021-10-19)
Macrophages promote early host responses to infection by releasing pro-inflammatory cytokines, and they are crucial to combat amoebiasis, a disease affecting millions of people worldwide. Macrophages elicit pro-inflammatory responses following direct cell/cell interaction of Entamoeba histolytica, inducing NLRP3 inflammasome activation
Peng Lin et al.
Journal of virology, 93(22) (2019-09-06)
Mink enteritis virus (MEV), an autonomous parvovirus, causes acute hemorrhagic enteritis in minks. The molecular pathogenesis of MEV infection has not been fully understood. In this study, we observed significantly increased apoptosis in the esophagus, small intestine, mesenteric lymph nodes
Yu-Mei Diao et al.
Molecular medicine reports, 12(2), 1951-1956 (2015-04-22)
Human corneal endothelial cells are a non-proliferative cell type. As a result of the increase in corneal endothelium disease, increasing numbers of studies have been conducted in order to promote corneal endothelial cell proliferation. The aim of the present study
Ana Clara Sabbione et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 74(1), 107-114 (2019-01-13)
Antiproliferative effect of Amaranthus mantegazzianus proteins and peptides released after simulated gastrointestinal digestion (DH% 37.8 ± 3.8) was investigated on human colon cancer cell line HT-29. Inhibition of proliferation of HT-29 cells was exhibited after a 24 h treatment with different concentrations of
Monika Kallubai et al.
Journal of biomolecular structure & dynamics, 37(3), 623-640 (2018-01-30)
Our study focus on the biological importance of synthesized 5β-dihydrocortisol (Dhc) and 5β-dihydrocortisol acetate (DhcA) molecules, the cytotoxic study was performed on breast cancer cell line (MCF-7) normal human embryonic kidney cell line (HEK293), the IC50 values for MCF-7 cells
William J Marringa et al.
PloS one, 9(10), e108486-e108486 (2014-10-07)
Multiple stress factors in honey bees are causing loss of bee colonies worldwide. Several infectious agents of bees are believed to contribute to this problem. The mechanisms of honey bee immunity are not completely understood, in part due to limited
Bingyu Zou et al.
Oncology reports, 38(3), 1431-1441 (2017-07-18)
Ovarian cancer is the most lethal gynecological malignancy in the world. Our previous studies showed that mangiferin, purified from plant source, possessed anti-neoplasm effect on human lung adenocarcinoma A549 cells. This study aimed to determine the apoptosis-inducing effect of mangiferin
Zheng Xu et al.
American journal of translational research, 14(1), 166-181 (2022-02-18)
Cabazitaxel has been applied to the treatment of castration-resistant prostate cancer (CRPC), but the molecular mechanism remained to be fully understood. After treatment with Cabazitaxel alone or in combination with ionizing radiation (IR), CRPC cell viability, proliferation and apoptosis were
ZhenZhen Zhan et al.
Autophagy, 8(1), 109-121 (2011-11-24)
Autophagy-associated release of HMGB1 is known to protect cancer cells from many chemotherapeutics. However, the detailed molecular mechanism(s) responsible remains largely undefined. We show in this study that HMGB1 released into the extracellular space protects gastric cancer cells from apoptosis
Wandayi Emmanuel Amlabu et al.
PloS one, 16(11), e0258996-e0258996 (2021-11-23)
In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with poverty and endemic in Africa
Dong-Mei Wu et al.
Journal of cellular physiology, 233(9), 6689-6704 (2017-12-08)
The present study was to investigate the effect of lncRNA LINC00880 targeting CACNG5 on cell proliferation, migration, invasion, and apoptosis in spinal cord ependymoma (SCE) through the MAPK signaling pathway. GEO database was used to download gene expression data related
Nadir Kocak et al.
Asian Pacific journal of cancer prevention : APJCP, 18(3), 735-739 (2017-04-27)
Fentanyl is an opioid analgesic that it is widely used in cancer patients. Since there have been reports of effects of analgesic medications on the recurrence and development of resistance to treatment, influences of of fentanyl on MCF-7 and HEK293
Jaspreet Kaur et al.
The Journal of antimicrobial chemotherapy, 68(5), 1071-1080 (2013-01-08)
To investigate the mode of action of monastrol in intracellular Leishmania. Microarray experiments were conducted on an Affymetrix GeneChip(®) Human Genome U133 Plus 2.0 Array, to determine the genes that encode proteins related to pathological alterations of cell signalling pathways
Daniel Pushparaju Yeggoni et al.
Journal of photochemistry and photobiology. B, Biology, 160, 248-259 (2016-05-01)
Here, we present the inclusive binding mode of phytochemical embelin, an anticancer drug with human serum albumin (HSA) established under physiological condition. Also, to understand the pharmacological role of embelin molecule, here, we have studied the anti-cancer activity of embelin
Lucie Pekarčíková et al.
Cellular signalling, 28(8), 924-936 (2016-04-25)
The c-Myb transcription factor is important for maintenance of immature cells of many tissues including colon epithelium. Overexpression of c-Myb occurring in colorectal carcinomas (CRC) as well as in other cancers often marks poor prognosis. However, the molecular mechanism explaining
Lina Liu et al.
Nature communications, 13(1), 3833-3833 (2022-07-06)
Chemo-resistance in acute myeloid leukemia (AML) patients is driven by leukemic stem cells (LSCs) resulting in high rates of relapse and low overall survival. Here, we demonstrate that upregulation of the splicing factor, RBM17 preferentially marks and sustains LSCs and
Qi-Quan Wu et al.
Journal of cellular biochemistry, 120(6), 10215-10227 (2019-01-15)
Prostate cancer is the second highest caused by cancer-related death among males. microRNAs (miRs) have been reported to participate in carcinogenesis, yet their roles in prostate cancer are rarely studied or investigated. Therefore, the present study attempted to explore the
S Hashemi et al.
Cell death discovery, 1, 15019-15019 (2015-01-01)
β1-Adrenergic receptor (β1-AR) stimulation increases apoptosis in cardiomyocytes through activation of cAMP/protein kinase A (PKA) signaling. The myocyte enhancer factor 2 (MEF2) proteins function as important regulators of myocardial gene expression. Previously, we reported that PKA signaling directly represses MEF2
Ming-Wei Chen et al.
Technology in cancer research & treatment, 17, 1533033818811143-1533033818811143 (2018-11-30)
Osteosarcoma is a highly malignant bone tumor. However, due to the high complexity of the occurrence and metastasis of osteosarcoma, the exact mechanism promoting its development and progression remains to be elucidated. This study highlights the causal link between solute
Hongtao Liu et al.
Veterinary research, 52(1), 30-30 (2021-02-24)
Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans and pigs worldwide. SS2 Enolase (Eno) has previously been identified
Irene V Bijnsdorp et al.
International journal of cancer, 126(10), 2457-2468 (2009-10-10)
Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death
Chunxiao Wang et al.
Medical science monitor : international medical journal of experimental and clinical research, 24, 9213-9222 (2018-12-19)
BACKGROUND Rheumatoid arthritis is an autoimmune disease that causes chronic joint inflammation and there is no cure. Baicalin, as an ingredient in the roots of Scutellaria baicalensis, is supposed to possess an anti-inflammatory effect. However, the protective effect of baicalin
Qian Kong et al.
Experimental and therapeutic medicine, 17(5), 3598-3606 (2019-04-17)
Acute lung injury (ALI) is a critical syndrome that is associated with high morbidity and mortality rates. The activation of the Fas/Fas ligand (FasL) signaling pathway may be an important pathophysiological mechanism during ALI development. Penehyclidine hydrochloride (PHC) has been
Sandhini Saha et al.
Cell death & disease, 13(6), 563-563 (2022-06-23)
Nutrient surplus and consequent free fatty acid accumulation in the liver cause hepatosteatosis. The exposure of free fatty acids to cultured hepatocyte and hepatocellular carcinoma cell lines induces cellular stress, organelle adaptation, and subsequent cell death. Despite many studies, the
Gayane Machkalyan et al.
Journal of molecular signaling, 11, 4-4 (2016-11-23)
Inositol hexakisphosphate kinase 2 (IP6K2) potentiates pro-apoptotic signalling and increases the sensitivity of mammalian cells to cytotoxic agents. Diphosphoinositol pentakisphosphate kinase (PPIP5K) generates inositol pyrophosphates (InsPPs) that are structurally distinct from those produced by IP6K2 and their possible roles in
Imran Khan et al.
Journal of cellular and molecular medicine, 19(10), 2397-2412 (2015-08-08)
Exposure of oral cavity to areca nut is associated with several pathological conditions including oral submucous fibrosis (OSF). Histopathologically OSF is characterized by epithelial atrophy, chronic inflammation, juxtaepithelial hyalinization, leading to fibrosis of submucosal tissue and affects 0.5% of the
Jay A Friedman et al.
Translational oncology, 6(4), 429-441 (2013-08-03)
Heat shock protein 90 (HSP90) is a chaperone protein that stabilizes proteins involved in oncogenic and therapeutic resistance pathways of epithelial cancers, including head and neck squamous cell carcinomas (HNSCCs). Here, we characterized the molecular, cellular, and preclinical activity of
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