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Showing 1-9 of 9 results for "APT403" within Papers
Mohammad Husein Abnosi et al.
Iranian journal of basic medical sciences, 15(4), 900-906 (2013-03-16)
Arsenic compounds are potent human carcinogen and produce a variety of stress responses in mammalian cells. Recently sodium arsenite has been recommended to be used as anti malignancy drug by American food and drug administration (FDA). In this study, we
Mohammad Hossein Abnosi et al.
Iranian journal of basic medical sciences, 18(4), 317-324 (2015-05-29)
In previous investigations, we have shown para-nonylphenol (p-NP) caused significant reduction of proliferation and differentiation of rat bone marrow mesenchymal stem cells (MSCs) in vitro. In this study, we first treat the rats with p-NP, then carried out the biochemical
Golnaz Pakravan et al.
Cell death & disease, 9(7), 758-758 (2018-07-11)
Doxorubicin (Dox) is a widely used powerful chemotherapeutic component for cancer treatment. However, its clinical application has been hampered due to doxorubicin-induced cardiomyopathy upon the cessation of chemotherapy. Previous studies revealed that PPARγ plays a crucial protective role in cardiomyocytes.
Lisa L Cunningham et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(19), 8532-8540 (2002-09-28)
Aminoglycoside exposure results in the apoptotic destruction of auditory and vestibular hair cells. This ototoxic hair cell death is prevented by broad-spectrum caspase inhibition. We have used in situ substrate detection, immunohistochemistry, and specific caspase inhibitors to determine which caspases
Bo Hua Hu et al.
Journal of neuroscience research, 88(8), 1812-1821 (2010-01-22)
Acoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl-2 family proteins. Myeloid cell leukemia sequence 1 (Mcl-l) is an antiapoptotic member of the Bcl-2 family. Its
Nasim-Sadat Kajabadi et al.
The Journal of biological chemistry, 290(43), 26303-26313 (2015-09-04)
Although human pluripotent stem cells (hPSCs) provide valuable sources for regenerative medicine, their applicability is dependent on obtaining both suitable up-scaled and cost effective cultures. The Rho-associated kinase (ROCK) inhibitor Y-27632 permits hPSC survival upon dissociation; however, cloning efficiency is
Sarita Nehra et al.
PloS one, 10(9), e0139121-e0139121 (2015-09-26)
Hypoxia induced oxidative stress incurs pathophysiological changes in hypertrophied cardiomyocytes by promoting translocation of p53 to mitochondria. Here, we investigate the cardio-protective efficacy of nanocurcumin in protecting primary human ventricular cardiomyocytes (HVCM) from hypoxia induced damages. Hypoxia induced hypertrophy was
Qunfeng Cai et al.
Neurobiology of disease, 45(2), 723-732 (2011-11-03)
Cell-cell junctions and junctions between cells and extracellular matrix are essential for maintenance of the structural and functional integrity of the cochlea, and are also a major target of acoustic trauma. While morphological assessments have revealed adhesion dysfunction in noise-traumatized
Rokhsareh Meamar et al.
Cell journal, 14(3), 185-192 (2013-03-20)
Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate. Mouse embryonic stem cells (mESCs) express only one glutamate receptor, the metabotropic glutamate receptor 5
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