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Showing 1-30 of 41 results for "B0529" within Papers
Luis M Colon-Perez et al.
NeuroImage. Clinical, 9, 58-68 (2015-09-29)
Emerging high-field diffusion weighted MR imaging protocols, along with tractography, can elucidate microstructural changes associated with brain disease at the sub-millimeter image resolution. Epilepsy and other neurological disorders are accompanied by structural changes in the hippocampal formation and associated regions;
Daniel J Spade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 167(2), 546-558 (2018-10-18)
Exposure to excess retinoic acid (RA) disrupts the development of the mammalian testicular seminiferous cord. However, the molecular events surrounding RA-driven loss of cord structure have not previously been examined. To investigate the mechanisms associated with this adverse developmental effect
Michal Lipinski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(42), 7984-8001 (2022-09-16)
Environmental factors and life experiences impinge on brain circuits triggering adaptive changes. Epigenetic regulators contribute to this neuroadaptation by enhancing or suppressing specific gene programs. The paralogous transcriptional coactivators and lysine acetyltransferases CREB binding protein (CBP) and p300 are involved
Annuska Berz et al.
Brain sciences, 12(11) (2022-11-12)
Rats, which are highly social animals, are known to communicate using ultrasonic vocalizations (USV) in different frequency ranges. Calls around 50 kHz are related to positive affective states and promote social interactions. Our previous work has shown that the playback
Pranita K Kabadi et al.
BioTechniques, 59(5), 279-286 (2015-11-12)
Three-dimensional (3-D) in vitro platforms have been shown to closely recapitulate human physiology when compared with conventional two-dimensional (2-D) in vitro or in vivo animal model systems. This confers a substantial advantage in evaluating disease mechanisms, pharmaceutical drug discovery, and
Amandine Saulnier et al.
Cerebral cortex (New York, N.Y. : 1991), 23(11), 2552-2567 (2012-08-28)
Regional patterning of the cerebral cortex is initiated by morphogens secreted by patterning centers that establish graded expression of transcription factors within cortical progenitors. Here, we show that Dmrt5 is expressed in cortical progenitors in a high-caudomedial to low-rostrolateral gradient.
Shaina P Cahill et al.
Neuroscience, 390, 241-255 (2018-09-04)
Adult neurogenesis has potential to ameliorate a number of disorders that negatively impact the hippocampus, including age-related cognitive decline, depression, and schizophrenia. A number of treatments enhance adult neurogenesis including exercise, NMDA receptor antagonism, antidepressant drugs and environmental enrichment. Despite
Jason S Snyder et al.
Hippocampus, 27(8), 871-882 (2017-05-06)
Different memory systems offer distinct advantages to navigational behavior. The hippocampus forms complex associations between environmental stimuli, enabling flexible navigation through space. In contrast, the dorsal striatum associates discrete cues and favorable behavioral responses, enabling habit-like, automated navigation. While these
Sex Differences in the Spatial Behavior Functions of Adult-Born Neurons in Rats.
O'Leary, et al.
eNeuro, 9 (2022)
Stefanie Reyes et al.
The Journal of comparative neurology, 520(12), 2591-2607 (2012-01-19)
G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans. We examined the localization of GIRK2 in the SN and adjacent
Matthew P Dent et al.
Toxicology in vitro : an international journal published in association with BIBRA, 60, 203-211 (2019-06-04)
The development and normal function of prostate tissue depends on signalling interactions between stromal and epithelial compartments. Development of a prostate microtissue composed of these two components can help identify substance exposures that could cause adverse effects in humans as
You Yu et al.
Anatomical record (Hoboken, N.J. : 2007), 297(2), 289-300 (2014-01-21)
We have used the histochemical and immunohistochemical staining methods and maps of gene expression to analyze the structure of the inferior olive of the C57BL mouse. As in other mammals, the inferior olive of the C57BL mouse contains three major
A Bertolo et al.
European cells & materials, 29, 70-80 (2015-01-13)
Degeneration of the intervertebral disc (IVD) is a progressive and chronic process, and the high incidence of discogenic disorders calls for new therapeutic approaches, such as cell-based therapies using three dimensional cultures and mesenchymal stem cells (MSC), which can differentiate
Megan O'Reilly et al.
Anatomical record (Hoboken, N.J. : 2007), 297(4), 758-769 (2014-01-21)
Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on
Shai Shoham et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 14(2), 251-262 (2018-10-22)
Effect of age and ladostigil treatment (1 mg/kg/day), given for 6 months to 16 month old rats, was investigated on microglial morphology in brain regions associated with control of spatial learning. This was assessed in the Morris water maze (MWM). Microglial morphology was
Anik Listiyana et al.
Open veterinary journal, 13(1), 99-107 (2023-02-14)
Oral squamous cell carcinoma (OSCC) is a malignant tumor that can rapidly infiltrate the oral epithelial tissue and cause high mortality worldwide because the available therapies are less effective. Chrysanthemum cinerariifolium leaf contains secondary metabolites as anti-inflammatory, antioxidant, anticancer, and
Emmanuel Márquez-Legorreta et al.
Frontiers in neuroanatomy, 10, 82-82 (2016-08-27)
The zone of transition between the pretectum, derived from prosomere 1, and the thalamus, derived from prosomere 2, is structurally complex and its understanding has been hampered by cytoarchitectural and terminological confusion. Herein, using a battery of complementary morphological approaches
C Ling et al.
Endocrinology, 141(10), 3564-3572 (2000-10-03)
There are indications that PRL may exert important metabolic actions on adipose tissue in different species. However, with the exception of birds, the receptor has not been identified in white adipose tissue. The present study was designed to examine the
Specific IgG for cat allergens in patients with allergic conjunctivitis.
Miyama A, et al.
International Ophthalmology, 35(4), 575-586 (2015)
Martina L Mustroph et al.
Behavioural brain research, 233(1), 141-148 (2012-05-09)
Tauopathy in the hippocampus is one of the earliest cardinal features of Alzheimer's disease (AD), a condition characterized by progressive memory impairments. In fact, density of tau neurofibrillary tangles (NFTs) in the hippocampus strongly correlates with severity of cognitive impairments
G Pascual et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(2), 365-372 (2014-06-05)
This study compares the behavior of several cross- and noncrosslinked biomeshes (Permacol®, CollaMend®, Surgisis®, Tutomesh®, and Strattice®) currently used for abdominal wall repair when implanted intraperitoneally and extraperitoneally. Material and Methods. Intraperitoneal (IP) implants were fixed on the parietal peritoneum
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Alessandro Bertolo et al.
European cells & materials, 21, 221-229 (2011-02-26)
Degeneration of intervertebral discs (IVD) is one of the main causes of back pain and tissue engineering has been proposed as a treatment. Tissue engineering requires the use of highly expensive growth factors, which might, in addition, lack regulatory approval
Melissa S Rotunno et al.
The Journal of biological chemistry, 289(41), 28527-28538 (2014-08-29)
Mutations and aberrant post-translational modifications within Cu,Zn-superoxide dismutase (SOD1) cause this otherwise protective enzyme to misfold, leading to amyotrophic lateral sclerosis (ALS). The C4F6 antibody selectively binds misfolded SOD1 in spinal cord tissues from postmortem human ALS cases, as well
S Shoham et al.
Annals of the New York Academy of Sciences, 1012, 94-114 (2004-04-24)
There is evidence suggesting that oxidative stress contributes to kainate neurotoxicity. Since iron promotes oxidative stress, the present study explores how change in nutritional iron content modulates kainate-induced neurotoxicity. Rats received an iron-deficient diet (ID) from 22 days of age
Man Wu et al.
International journal of oncology, 57(3), 845-857 (2020-07-25)
Hepatocellular carcinoma (HCC) is the fourth most common cancer type worldwide, with a poor prognosis and high mortality rate. The aim of the present study was to investigate the mechanisms underlying HCC progression to potentially benefit the development of effective therapies
Shaina P Cahill et al.
Hippocampus, 27(11), 1155-1167 (2017-07-08)
The storage and persistence of memories depends on plasticity in the hippocampus. Adult neurogenesis produces new neurons that mature through critical periods for plasticity and cellular survival, which determine their contributions to learning and memory. However, most granule neurons are
Meira Maria Forcelini Machado et al.
Pharmacological reports : PR, 71(4), 556-564 (2019-05-28)
Peroxisome proliferator-activated receptor γ (PPAR-γ) agonists have received much attention in research because of their neuroprotective and anti-inflammatory effects that reduce cell death and halt the progression of neurodegeneration. Thus, this study observed the pioglitazone effects on the main inflammatory
Erica Rosemond et al.
The Journal of biological chemistry, 277(9), 7333-7340 (2001-12-18)
The amino-terminal domain containing the ligand binding site of the G protein-coupled metabotropic glutamate receptors (mGluRs) consists of two lobes that close upon agonist binding. In this study, we explored the ligand binding pocket of the Group III mGluR4 receptor
Levan Muskhelishvili et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 51(12), 1681-1688 (2003-11-19)
The standard method for assessment of cell proliferation in paraffin-embedded tissue sections is 5-bromodeoxyuridine (BrdU) immunohistochemistry (IHC). BrdU can be administered to laboratory animals via IP injections, is readily incorporated into nuclei during the DNA synthetic phase of the cell
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