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Showing 1-30 of 126 results for "B0753" within Papers
Hiroki Mani et al.
Acta histochemica et cytochemica, 48(1), 1-8 (2015-04-11)
The calcium (Ca(2+))-paradox injury of the heart, induced by restoration of extracellular Ca(2+) after its short-term depletion, is known to provoke cardiomyocyte contracture. However, undetermined is how the Ca(2+)-paradox provokes such a distinctive presentation of myocytes in the heart. To
Joshua R St Clair et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H490-H498 (2015-05-24)
Pacemaker myocytes in the sinoatrial node of the heart initiate each heartbeat by firing spontaneous action potentials. However, the molecular processes that underlie pacemaking are incompletely understood, in part because of our limited ability to manipulate protein expression within the
Yinglong Tang et al.
Scientific reports, 5, 16083-16083 (2015-11-05)
RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered splicing of calcium channels, such as ryanodine receptors (RyRs), plays an important role in impaired excitation-contraction (E-C) coupling in muscle atrophy; however
Shaiban Jubair et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H676-H684 (2015-06-14)
Accumulating evidence indicates that substance P is cardioprotective following ischemia-reperfusion primarily due to its potent coronary vasodilator actions. However, an anti-apoptotic effect of substance P has been observed in tenocytes following ischemia, which involved activation of the AKT pathway. This
Chih-Wei Chou et al.
PloS one, 9(9), e107997-e107997 (2014-09-24)
While the endothelium-organ interaction is critical for regulating cellular behaviors during development and disease, the role of blood flow in these processes is only partially understood. The dorsal aorta performs paracrine functions for the timely migration and differentiation of the
Effect of strain on actomyosin kinetics in isometric muscle fibers
Siththanandan VB, et al.
Biophysical Journal, 90(10), 3653-3665 (2006)
Camilla Schinner et al.
Acta physiologica (Oxford, England), 226(2), e13242-e13242 (2018-12-26)
Mutations in desmosomal proteins can induce arrhythmogenic cardiomyopathy with life-threatening arrhythmia. Previous data demonstrated adrenergic signalling to be important to regulate desmosomal cohesion in cardiac myocytes. Here, we investigated how signalling pathways including adrenergic signalling, PKC and SERCA regulate desmosomal
L Taysse et al.
Human & experimental toxicology, 30(6), 491-498 (2010-06-11)
Using the hairless mouse screening model presented in the companion paper(1) the aim of this study was to assess two skin decontaminating systems: Fuller's earth (FE) and Reactive Skin Decontamination Lotion (RSDL) against two extremely toxic chemical warfare agents that
Yunzhe Wang et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(6), 1170-1181 (2019-01-15)
Mouse mast cell protease-4 (mMCP4) is a chymase that has been implicated in cardiovascular diseases, including myocardial infarction (MI). This study tested a direct role of mMCP4 in mouse post-MI cardiac dysfunction and myocardial remodeling. Immunoblot and immunofluorescent double staining
Ryuichi Fukuda et al.
Developmental cell, 51(1), 62-77 (2019-09-10)
Mechanical forces regulate cell behavior and tissue morphogenesis. During cardiac development, mechanical stimuli from the heartbeat are required for cardiomyocyte maturation, but the underlying molecular mechanisms remain unclear. Here, we first show that the forces of the contracting heart regulate
M D Schwartz et al.
Current pharmaceutical biotechnology, 13(10), 1971-1979 (2012-02-23)
Rapid decontamination of the skin is the single most important action to prevent dermal absorption of chemical contaminants in persons exposed to chemical warfare agents (CWA) and toxic industrial chemicals (TICs) as a result of accidental or intentional release. Chemicals
Venkatakaushik Voleti et al.
Nature methods, 16(10), 1054-1062 (2019-09-29)
The limited per-pixel bandwidth of most microscopy methods requires compromises between field of view, sampling density and imaging speed. This limitation constrains studies involving complex motion or fast cellular signaling, and presents a major bottleneck for high-throughput structural imaging. Here
Suraj Kannan et al.
Cell reports, 42(4), 112330-112330 (2023-04-05)
A limitation in the application of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is the failure of these cells to achieve full functional maturity. The mechanisms by which directed differentiation differs from endogenous development, leading to consequent PSC-CM maturation arrest, remain unclear.
T L Veum et al.
Journal of animal science, 93(1), 197-208 (2015-01-09)
The experimental objective was to evaluate swine methane digester effluent (SMDE) as a water and nutrient source for swine. The mesophilic methane digester was loaded daily with manure from finishing swine fed a corn-soybean meal diet. Dry diet was mixed
Tatsuhito Matsuo et al.
Biophysical journal, 99(1), 193-200 (2010-07-27)
The interaction of troponin molecules on the thin filament with Ca(2+) plays a key role in regulating muscle contraction. To characterize the structural changes of troponin caused by Ca(2+) and crossbridge formation, we recorded the small-angle x-ray intensity and the
R Waurick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(6), 484-492 (1999-08-04)
The aim of the study was to investigate the effects of the putative protein phosphatase (PP) activator 2,3-butanedione monoxime (BDM) in vascular smooth muscle. BDM concentration-dependently increased PP activity in homogenates of bovine coronary arteries and led to dephosphorylation of
Allen C T Teng et al.
Nature communications, 13(1), 6166-6166 (2022-10-19)
The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound transmembrane protein 65 (Tmem65) was required for connexin43 (Cx43) localization
Stacey L Edwards et al.
Genetics, 201(1), 91-116 (2015-09-12)
The functional integrity of neurons requires the bidirectional active transport of synaptic vesicles (SVs) in axons. The kinesin motor KIF1A transports SVs from somas to stable SV clusters at synapses, while dynein moves them in the opposite direction. However, it
Sheila Ryan et al.
Environmental microbiology, 11(2), 432-445 (2009-02-07)
The capacity of Listeria monocytogenes to withstand low pH is important for growth in low-pH foods, successful passage through the gastric barrier and survival within the macrophage phagosome. The ability of this pathogen to survive and adapt to acidic conditions
Min Jeong Ji et al.
Antioxidants (Basel, Switzerland), 11(9) (2022-09-24)
The biomarker 8-hydroxy-2'-deoxyguanosine (oh8dG) is derived from oxidized nucleic acids or products of oxidant-mediated DNA damage. Enhanced sodium bicarbonate cotransporter (NBC) activity is caused by reactive oxygen species (ROS) production in ventricular myocytes. Thus, we hypothesized that cardioplegia-solution-mediated ROS generation
Arthur Forer et al.
Protoplasma, 225(1-2), 1-4 (2005-05-04)
BDM (2,3-butanedione monoxime) has been used extensively to inhibit nonmuscle myosin. However, recent articles raise the question of what BDM actually does, because of experiments in which BDM did not affect the actin-activated ATPase of nonmuscle myosins. We describe results
Mathias Nyman et al.
American journal of physiology. Heart and circulatory physiology, 326(1), H203-H215 (2023-11-17)
Ventricular arrhythmias contribute significantly to cardiovascular mortality, with coronary artery disease as the predominant underlying cause. Understanding the mechanisms of arrhythmogenesis is essential to identify proarrhythmic factors and develop novel approaches for antiarrhythmic prophylaxis and treatment. Animal models are vital
Huiling Zhou et al.
Molecular and cellular biochemistry, 476(2), 1233-1243 (2020-11-29)
Vinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial damage has been continually reported. The underlying molecular mechanism of the myocardial damage remains unknown. Here, we show that vinblastine induces myocardial damage and
Janine E Radford et al.
Protoplasma, 248(1), 205-216 (2010-11-30)
Actin and myosin are components of plasmodesmata, the cytoplasmic channels between plant cells, but their role in regulating these channels is unclear. Here, we investigated the role of myosin in regulating plasmodesmata in a well-studied, simple system comprising single filaments
Kohsuke Hashimoto et al.
Biotechnology letters, 33(4), 769-775 (2010-12-18)
The plant-saprophytic basidiomycete, Coprinopsis cinerea, produces and secretes various cellulases during cellulose degradation as the main extracellular proteins. Although enzymatic characterization of such cellulases has been frequently reported, the mechanism of their secretion remains unclear. This study focused on myosins
Yankun Lyu et al.
iScience, 25(1), 103624-103624 (2022-01-11)
The mammalian heart beats incessantly with rhythmic mechanical activities generating acids that need to be buffered to maintain a stable intracellular pH (pHi) for normal cardiac function. Even though spatial pHi non-uniformity in cardiomyocytes has been documented, it remains unknown
Noboru Yamada et al.
Plant signaling & behavior, 6(11), 1651-1653 (2011-11-08)
In a recent publication using an actin-visualized line of Arabidopsis (Ichikawa et al. 2011, ref. 11), we reported a detailed analysis with higher time resolution on the dynamics of chloroplast actin filaments (cp-actin filaments) during chloroplast avoidance movement and demonstrated
Christine M Poch et al.
Bio-protocol, 13(13), e4750-e4750 (2023-07-17)
Cardiovascular diseases are the leading cause of death and morbidity worldwide. Patient mortality has been successfully reduced by nearly half in the last four decades, mainly due to advances in minimally invasive surgery techniques and interventional cardiology methods. However, a
Marcos Sande-MelĆ³n et al.
Cell reports, 29(4), 1041-1054 (2019-10-24)
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10
Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice.
Hu, et al.
Alcoholism, Clinical and Experimental Research, 46, 707-723 (2022)
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