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Showing 1-30 of 45 results for "B1141000" within Papers
Andrea C Lo et al.
International journal of radiation oncology, biology, physics, 88(5), 1011-1018 (2014-03-26)
We report long-term outcomes and complications of craniopharyngioma patients referred to our institution. Between 1971 and 2010, 123 consecutive patients received primary treatment for craniopharyngioma in British Columbia and were referred to our institution. The median age was 30 years
Pitfalls in management of patients with germ cell tumors and slight elevation of serum α-fetoprotein.
Costantine Albany et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(19), 2114-2115 (2014-05-21)
Konrad Pielaciński et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 37(222), 344-347 (2015-02-27)
One extremely rare complication of chemotherapy for hematologic malignancies that is burdened with a high mortality rate (50%-80%) is necrotizing gastritis and gastric gangrene as result of poor clinical outcome of neutropenic gastritis (NG). We present a unique case of
Thierry Jo Molina et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(35), 3996-4003 (2014-11-12)
To determine whether any tumor biomarkers could account for the survival advantage observed in the LNH 03-2B trial among patients with diffuse large B-cell lymphoma (DLBCL) and low-intermediate risk according to the International Prognostic Index when treated with dose-intensive rituximab
Elizabeth F Redente et al.
American journal of respiratory cell and molecular biology, 50(4), 825-837 (2013-12-12)
Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which alternatively programmed macrophages produce profibrotic molecules that promote myofibroblast survival and collagen synthesis. Effective therapies to treat patients with IPF are lacking, and conventional therapy may be
Jie-jie Geng et al.
Biochimica et biophysica acta, 1842(9), 1770-1782 (2014-06-17)
Lung interstitial fibrosis is a chronic lung disease, and few effective therapies are available to halt or reverse the progression of the disease. In murine and human lung fibrosis, the expression of CD147 is increased. However, the role of CD147
Yong-Jiang Tang et al.
American journal of respiratory cell and molecular biology, 51(6), 761-771 (2014-06-03)
Transforming growth factor (TGF)-β1 is a potent mediator known to induce lung fibrosis. However, the role of latent TGF-β1 in lung inflammation and fibrosis is unclear. To investigate the role of circulating latent TGF-β1 in bleomycin-induced lung injury, lung disease
Shota Kurotsu et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 79-88 (2014-04-29)
Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis.
Pulmonary lymphocyte-rich classical Hodgkin lymphoma with early response to ABVD therapy.
Akira Honda et al.
Annals of hematology, 93(6), 1073-1074 (2013-11-01)
Aravind T Reddy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5299-5310 (2014-09-26)
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease, thought to be largely transforming growth factor β (TGFβ) driven, for which there is no effective therapy. We assessed the potential benefits in IPF of nitrated fatty acids (NFAs), which are
Robert D Guzy et al.
American journal of respiratory cell and molecular biology, 52(1), 116-128 (2014-07-06)
The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung function. In vitro, fibroblast growth factor (FGF) 2 promotes myofibroblast differentiation and proliferation in cooperation with the
Jibing Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 306(8), L786-L796 (2014-02-11)
Fibrogenesis involves a pathological accumulation of activated fibroblasts and extensive matrix remodeling. Profibrotic cytokines, such as TGF-β, stimulate fibroblasts to overexpress fibrotic matrix proteins and induce further expression of profibrotic cytokines, resulting in progressive fibrosis. Connective tissue growth factor (CTGF)
Karim Fizazi et al.
The Lancet. Oncology, 15(13), 1442-1450 (2014-12-03)
Poor prognosis germ-cell tumours are only cured in about half of patients. We aimed to assess whether treatment intensification based on an early tumour marker decline will improve progression-free survival for patients with germ-cell tumours. In this phase 3, multicentre
Mengfan Tang et al.
The Journal of biological chemistry, 289(49), 34024-34032 (2014-10-09)
Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) has been shown to be involved in gene silencing and DNA damage. However, the exact mechanisms of how SMCHD1 participates in DNA damage remains largely unknown. Here we present evidence
Eun Jung Choi et al.
Korean journal of radiology, 15(4), 448-455 (2014-07-24)
The aim of this study was to assess the therapeutic effects of rosiglitazone with serial micro-CT findings before and after rosiglitazone administration in a lung fibrosis mouse model induced with bleomycin. We instilled the bleomycin solution directly into the trachea
Chi-An Chen et al.
European journal of cancer (Oxford, England : 1990), 50(18), 3161-3167 (2014-12-03)
The combination of bleomycin, etoposide and cisplatin (BEP) is currently the most widely used treatment for malignant ovarian germ cell tumours (MOGCTs). The aim of this study was to evaluate the efficacy and adverse effects of the 3-day BEP regimen
Jakob Lauritsen et al.
International journal of cancer, 135(7), 1733-1739 (2014-03-04)
Estimates of glomerular filtration rate (eGFR) are widely used when administering nephrotoxic chemotherapy. No studies performed in oncology patients have shown whether eGFR can safely substitute a measured GFR (mGFR) based on a marker method. We aimed to assess the
Abraham Avigdor et al.
Annals of hematology, 93(8), 1297-1304 (2014-03-07)
The choice of a rituximab-based regimen and the prognostic significance of interim 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in primary mediastinal large B cell lymphoma (PMBCL) are debatable. We evaluated the clinical features and outcomes of 95 consecutive patients with PMBCL
Benjamin Bondue et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 127-132 (2014-12-30)
Idiopathic pulmonary fibrosis is characterized by a progressive and irreversible respiratory failure. Validated noninvasive methods able to assess disease activity are essential for prognostic purposes as well as for the evaluation of emerging antifibrotic treatments. C57BL/6 mice were used in
Théodore Girinsky et al.
International journal of radiation oncology, biology, physics, 89(5), 1047-1052 (2014-07-19)
This study examines the role of (18)F-labeled fluorodeoxyglucose positron emission tomography (FDG-PET) in the implementation of involved-node radiation therapy (INRT) in patients treated for clinical stages (CS) I/II supradiaphragmatic Hodgkin lymphoma (HL). Patients with untreated CS I/II HL enrolled in
Benkui Zou et al.
Journal of cancer research and clinical oncology, 140(10), 1733-1738 (2014-06-08)
Combination chemotherapy is emerging in the management of advanced penile cancer. However, evidence-based chemotherapeutic regimens in the current guidelines are lacking. The aim of this study was to evaluate the efficacy of preoperative neoadjuvant chemotherapy combined with a BMP regimen
Scott McAuley et al.
Cell chemical biology, 26(9), 1274-1282 (2019-07-08)
Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital Achilles heel in a pathogen of
Narayana Kilarkaje
Cancer chemotherapy and pharmacology, 74(6), 1175-1189 (2014-09-23)
To investigate the effects of therapeutically relevant dose levels of bleomycin, etoposide and cisplatin (BEP) on testicular steroidogenic enzymes, and possible protective effects of an antioxidant cocktail (AC). Adult Sprague-Dawley rats received BEP with or without the AC (α-tocopherol, L-ascorbic
Ananth Shankar et al.
British journal of haematology, 165(4), 534-544 (2014-04-24)
The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]
Arianna Carolina Rosa et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 308-316 (2014-09-04)
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation and accumulation of extracellular matrix components, is a major therapeutic challenge for which new therapeutic strategies are warranted. Cyclooxygenase (COX) inhibitors have been previously utilized to reduce inflammation. Histamine
Reply: a novel murine model of hypertrophic scarring using subcutaneous infusion of bleomycin.
Alexander M Cameron
Plastic and reconstructive surgery, 134(1), 164e-164e (2014-07-17)
Ying Meng et al.
American journal of respiratory cell and molecular biology, 50(4), 723-736 (2013-10-31)
Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts the activity of the ACE/AngII/AT1R axis, has been shown to protect against pulmonary
A novel murine model of hypertrophic scarring using subcutaneous infusion of bleomycin.
Bulent Sacak et al.
Plastic and reconstructive surgery, 134(1), 163e-164e (2014-07-17)
Different clones of acute leukemia after successful treatment of Hodgkin's disease.
Ulf Schnetzke et al.
Annals of hematology, 93(12), 2077-2079 (2014-05-08)
Elika Farrokhi Moshai et al.
American journal of respiratory cell and molecular biology, 51(1), 11-25 (2014-01-24)
Idiopathic pulmonary fibrosis has been associated with the reactivation of developmental pathways, notably the Hedgehog-Glioma-associated oncogene homolog (GLI) pathway. In this study, we determined whether the Hedgehog pathway was activated in bleomycin-induced lung injury in mice, and whether targeting the
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