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B2434
Keyword:'B2434'
Showing 1-30 of 101 results for "B2434" within Papers
International journal of radiation oncology, biology, physics, 88(5), 1011-1018 (2014-03-26)
We report long-term outcomes and complications of craniopharyngioma patients referred to our institution. Between 1971 and 2010, 123 consecutive patients received primary treatment for craniopharyngioma in British Columbia and were referred to our institution. The median age was 30 years
Pitfalls in management of patients with germ cell tumors and slight elevation of serum α-fetoprotein.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(19), 2114-2115 (2014-05-21)
American journal of physiology. Lung cellular and molecular physiology, 306(2), L120-L131 (2013-11-19)
Previous reports demonstrated that bleomycin-induced injury of lungs in mice can be improved by the administration of murine multipotent adult stem/progenitor cells (MSCs) from the bone marrow. Recently some of the beneficial effects of MSCs have been explained by the
Laboratory investigation; a journal of technical methods and pathology, 93(11), 1219-1231 (2013-09-18)
The transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway has a central role in pathogenesis of lung fibrosis. In the present study, we investigated if all-trans retinoic acid (ATRA) could attenuate fibrosis in bleomycin (BLM)-induced lung fibrosis in rats through regulating TGF-β1/Smad3
Biochimica et biophysica acta, 1842(9), 1770-1782 (2014-06-17)
Lung interstitial fibrosis is a chronic lung disease, and few effective therapies are available to halt or reverse the progression of the disease. In murine and human lung fibrosis, the expression of CD147 is increased. However, the role of CD147
American journal of respiratory cell and molecular biology, 50(4), 825-837 (2013-12-12)
Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which alternatively programmed macrophages produce profibrotic molecules that promote myofibroblast survival and collagen synthesis. Effective therapies to treat patients with IPF are lacking, and conventional therapy may be
The European respiratory journal, 30(2), 205-213 (2007-05-17)
Epithelial cell injury and apoptosis are recognised as early features in idiopathic pulmonary fibrosis and bleomycin-induced fibrosis in mice. Telomerase is a known apoptosis-alleviating factor. The role of telomerase was studied during bleomycin-induced lung epithelial cell (LEC) apoptosis in vitro
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(35), 3996-4003 (2014-11-12)
To determine whether any tumor biomarkers could account for the survival advantage observed in the LNH 03-2B trial among patients with diffuse large B-cell lymphoma (DLBCL) and low-intermediate risk according to the International Prognostic Index when treated with dose-intensive rituximab
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 37(222), 344-347 (2015-02-27)
One extremely rare complication of chemotherapy for hematologic malignancies that is burdened with a high mortality rate (50%-80%) is necrotizing gastritis and gastric gangrene as result of poor clinical outcome of neutropenic gastritis (NG). We present a unique case of
Bulletin du cancer, 100(4), 317-321 (2013-04-17)
We describe three cases of intravascular lymphoma B with different clinical presentation: one case of a cutaneous variant and two cases with surrenal and cutaneous localisation. All patients are in complete remission after chemotherapy alone or after chemotherapy and autologous
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(9), 927-930 (2013-09-10)
To investigate the intervention effects and mechanisms of the compound panax notoginsenoside granules (CPNG) on bleomycin-induced pulmonary fibrosis in rats. Sixty male Sprague-Dawley rats were randomly divided into 6 groups, including normal control group, model group, prednisolone group, and CPNG
Pulmonary lymphocyte-rich classical Hodgkin lymphoma with early response to ABVD therapy.
Annals of hematology, 93(6), 1073-1074 (2013-11-01)
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(12), 1522-1529 (2013-03-20)
Older patients with Hodgkin lymphoma (HL) account for approximately 20% of all HL patients. ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy is regarded as standard of care in these patients. However, little is known on feasibility and efficacy of ABVD
The Journal of pharmacology and experimental therapeutics, 350(1), 79-88 (2014-04-29)
Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 23(10), 752-753 (2013-10-12)
Hodgkin's lymphoma has been traditionally defined as a hematopoietic neoplasm composed of diagnostic Reed-Sternberg cells. More than 70% of the cases involve cervical or supraclavicular lymph nodes. Isolated sub-diaphragmatic lymphadenopathy or organ involvement is rare. We present the case of
Toxicology letters, 219(2), 178-193 (2013-03-26)
Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating and fatal lung disorder with high mortality rate. Unfortunately, to date the treatment for IPF remains unsatisfying and in severe cases lung transplantations are performed as a therapeutic measure. Thus, it becomes
British journal of cancer, 109(10), 2560-2565 (2013-10-19)
Myelotoxicity during initial cycles of chemotherapy for Hodgkin lymphoma is associated with better outcome, supporting the concept of individualised dosing based on pharmacodynamic end points to optimise results. This study was performed to identify the maximum tolerated dose (MTD) of
American journal of respiratory cell and molecular biology, 39(1), 45-52 (2008-02-16)
The roles of sex hormones as modulators of lung function and disease have received significant attention as differential sex responses to various lung insults have been recently reported. The present study used a bleomycin-induced pulmonary fibrosis model in C57BL/6 mice
Toxicology letters, 224(3), 387-394 (2013-11-26)
Hydrogen sulfide (H2S) displays vasodilative, anti-oxidative, anti-inflammatory and cytoprotective activities. The objective of this study was to evaluate the inhibitory effect of H2S on bleomycin (BLM)-induced pulmonary fibrosis in rats and its possible mechanisms. Fifty-four pathogen-free Male Wistar rats were
New light is shed on the enigmatic origin of the lung myofibroblast.
American journal of respiratory and critical care medicine, 188(7), 765-766 (2013-10-03)
The Lancet. Oncology, 15(13), 1442-1450 (2014-12-03)
Poor prognosis germ-cell tumours are only cured in about half of patients. We aimed to assess whether treatment intensification based on an early tumour marker decline will improve progression-free survival for patients with germ-cell tumours. In this phase 3, multicentre
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5299-5310 (2014-09-26)
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease, thought to be largely transforming growth factor β (TGFβ) driven, for which there is no effective therapy. We assessed the potential benefits in IPF of nitrated fatty acids (NFAs), which are
Tumori, 99(1), 51-56 (2013-04-04)
Our aim was to analyze treatment results and survival characteristics of our patients with malignant sacrococcygeal germ cell tumors. Patient files of children with malignant sacrococcygeal germ cell tumors, treated at our institution between 1979 and 2009, were searched. Patient
American journal of physiology. Lung cellular and molecular physiology, 306(8), L786-L796 (2014-02-11)
Fibrogenesis involves a pathological accumulation of activated fibroblasts and extensive matrix remodeling. Profibrotic cytokines, such as TGF-β, stimulate fibroblasts to overexpress fibrotic matrix proteins and induce further expression of profibrotic cytokines, resulting in progressive fibrosis. Connective tissue growth factor (CTGF)
Korean journal of radiology, 15(4), 448-455 (2014-07-24)
The aim of this study was to assess the therapeutic effects of rosiglitazone with serial micro-CT findings before and after rosiglitazone administration in a lung fibrosis mouse model induced with bleomycin. We instilled the bleomycin solution directly into the trachea
American journal of physiology. Lung cellular and molecular physiology, 304(11), L757-L764 (2013-04-16)
Myofibroblast differentiation induced by transforming growth factor-β (TGF-β) is characterized by the expression of smooth muscle α-actin (SMA) and extracellular matrix proteins. We and others have previously shown that these changes are regulated by protein kinase A (PKA). Adrenomedullin (ADM)
European journal of cancer (Oxford, England : 1990), 50(18), 3161-3167 (2014-12-03)
The combination of bleomycin, etoposide and cisplatin (BEP) is currently the most widely used treatment for malignant ovarian germ cell tumours (MOGCTs). The aim of this study was to evaluate the efficacy and adverse effects of the 3-day BEP regimen
Nature structural & molecular biology, 20(3), 387-395 (2013-02-19)
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized. To map supercoiling, we used biotinylated trimethylpsoralen as a
Anticancer research, 33(9), 3879-3885 (2013-09-12)
Hodgkin lymphoma (HL) is characterized by malignant Reed-Sternberg cells which express CD30. Current National Comprehensive Cancer Network guidelines for patients with advanced HL (stage III/IV disease) recommend adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), or escalated bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine
International journal of cancer, 135(7), 1733-1739 (2014-03-04)
Estimates of glomerular filtration rate (eGFR) are widely used when administering nephrotoxic chemotherapy. No studies performed in oncology patients have shown whether eGFR can safely substitute a measured GFR (mGFR) based on a marker method. We aimed to assess the
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