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Showing 1-30 of 49 results for "C0250" within Papers
Bárbara M Calisto et al.
Cell chemical biology, 28(1), 26-33 (2020-10-24)
Despite possessing only 32 residues, the tsetse thrombin inhibitor (TTI) is among the most potent anticoagulants described, with sub-picomolar inhibitory activity against thrombin. Unexpectedly, TTI isolated from the fly is 2000-fold more active and 180 Da heavier than synthetic and recombinant
Mathilde Bouchet et al.
Cancer research, 80(13), 2914-2926 (2020-05-06)
Bone is the most common metastatic site for breast cancer. Although the estrogen-related receptor alpha (ERRα) has been implicated in breast cancer cell dissemination to the bone from the primary tumor, its role after tumor cell anchorage in the bone
M Orozco-Levi et al.
The European respiratory journal, 13(2), 371-378 (1999-03-05)
Pulmonary hyperinflation impairs the function of the diaphragm in patients with chronic obstructive pulmonary disease (COPD). However, it has been recently demonstrated that the muscle can counterbalance this deleterious effect, remodelling its structure (i.e. changing the proportion of different types
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model
Almolda B, et al.
Journal of Neuroimmunology, 209(1-2), 65-80 (2009)
Panseon Ko et al.
International journal of molecular sciences, 22(11) (2021-07-03)
During aggressive cancer progression, cancer cells adapt to unique microenvironments by withstanding various cellular stresses, including endoplasmic reticulum (ER) stress. However, the mechanism whereby cancer cells overcome the ER stress to survive remains to be elucidated. Herein, we demonstrated that
Wen-Jui Lee et al.
Cancer medicine, 8(10), 4821-4835 (2019-07-06)
Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes. A neuroblastoma cell line (N2a) treated with either serum withdrawal (<2.5%) or
Subhadeep Roy et al.
Journal of cellular physiology, 234(4), 4015-4029 (2018-09-18)
The study elucidates the effect of ɑ-linolenic acid (ALA) on mitochondrial stress, hypoxic cancer microenvironment, and intervention of cholinergic anti-inflammatory pathway using N-methyl-N-nitrosourea (MNU) induced estrogen receptor (ER+) mammary gland carcinoma and Caenorhabditis elegans model, respectively. The efficacy of ALA
Thomas E Hall et al.
Bio-protocol, 8(22), e3088-e3088 (2018-11-20)
The recent development of 3D electron microscopic techniques for cells and tissues has necessitated the development of new methods for the detection of proteins and protein-complexes in situ. The development of new genetic tags, such as the ascorbate peroxidase, APEX
Ece Bayir et al.
International journal of biological macromolecules, 126, 1002-1013 (2019-01-01)
There are several blood-brain barrier (BBB) models available for pharmaceutical research, but none of those are able to properly imitate the permeability of this special barrier. In this study, it is aimed to produce different BBB models with different cellular
Komal Panchal et al.
Biology open, 9(9) (2020-08-05)
Miro (mitochondrial Rho GTPases), a mitochondrial outer membrane protein, facilitates mitochondrial axonal transport along the microtubules to facilitate neuronal function. It plays an important role in regulating mitochondrial dynamics (fusion and fission) and cellular energy generation. Thus, Miro might be
Wim Martinet et al.
Autophagy, 9(3), 386-402 (2012-12-18)
Transmission electron microscopy (TEM) is an indispensable standard method to monitor macroautophagy in tissue samples. Because TEM is time consuming and not suitable for daily routine, many groups try to identify macroautophagy in tissue by conventional immunohistochemistry. The aim of
Dean Brady et al.
BMC biotechnology, 8, 8-8 (2008-02-02)
Enzymes have found extensive and growing application in the field of chemical organic synthesis and resolution of chiral intermediates. In order to stabilise the enzymes and to facilitate their recovery and recycle, they are frequently immobilised. However, immobilisation onto solid
Heeseon An et al.
Molecular cell, 74(5), 891-908 (2019-04-23)
Cells respond to nutrient stress by trafficking cytosolic contents to lysosomes for degradation via macroautophagy. The endoplasmic reticulum (ER) serves as an initiation site for autophagosomes and is also remodeled in response to nutrient stress through ER-phagy, a form of
M Domínguez-Álvaro et al.
Cerebral cortex (New York, N.Y. : 1991), 31(1), 410-425 (2020-09-06)
The entorhinal cortex (EC) is a brain region that has been shown to be essential for memory functions and spatial navigation. However, detailed three-dimensional (3D) synaptic morphology analysis and identification of postsynaptic targets at the ultrastructural level have not been
Subhadeep Roy et al.
Oncotarget, 8(41), 70049-70071 (2017-10-21)
Alpha linolenic acid is an essential polyunsaturated fatty acid and is reported to have the anti-cancer potential with no defined hypothesis or mechanism/s. Henceforth present study was in-quested to validate the effect of alpha linolenic acid on mitochondrial apoptosis, hypoxic
Elisheva B Goldman et al.
Tissue engineering. Part A, 21(5-6), 1013-1023 (2014-11-05)
Impaired salivary gland (SG) function leading to oral diseases is relatively common with no adequate solution. Previously, tissue engineering of SG had been proposed to overcome this morbidity, however, not yet clinically available. Multiwall inorganic (tungsten disulfide [WS2]) nanotubes (INT-WS2)
Subhadeep Roy et al.
Cell biochemistry and function, 38(5), 591-603 (2020-03-25)
Gamma linolenic acid is a polyunsaturated fatty acid having selective anti-tumour properties with negligible systemic toxicity. In the present study, the anti-cancer potential of gamma linolenic acid and its effects on mitochondrial as well as hypoxia-associated marker was evaluated. The
Bhagyashree S Joshi et al.
ACS nano, 14(4), 4444-4455 (2020-04-14)
Extracellular vesicles (EVs), such as exosomes, can mediate long-distance communication between cells by delivering biomolecular cargo. It is speculated that EVs undergo back-fusion at multivesicular bodies (MVBs) in recipient cells to release their functional cargo. However, direct evidence is lacking.
Giorgia Montalbano et al.
Nanomaterials (Basel, Switzerland), 10(9) (2020-09-02)
Bone-tissue regeneration induced by biomimetic bioactive materials is the most promising approach alternative to the clinical ones used to treat bone loss caused by trauma or diseases such as osteoporosis. The goal is to design nanostructured bioactive constructs able to
Ágnes Bánréti et al.
Autophagy, 8(4), 623-636 (2012-02-15)
Protein phosphatase 2A (PP2A) holoenzyme is a heterotrimeric complex, consisting of A, B and C subunits. The catalytic subunit PP2A-C (microtubule star/mts) binds to the C-terminal part of the scaffold protein PP2A-A (PP2A-29B). In Drosophila, there are three different forms
Sandy Picot et al.
Autophagy, 15(10), 1801-1809 (2019-04-04)
Macroautophagy is a mechanism that is involved in various cellular processes, including cellular homeostasis and innate immunity. This pathway has been described in organisms ranging in complexity from yeasts to mammals, and recent results indicate that it occurs in the
Luigi Clauser et al.
PloS one, 9(11), e110796-e110796 (2014-11-07)
Structural fat grafting utilizes the centrifugation of liposuction aspirates to create a graded density of adipose tissue. This study was performed to qualitatively investigate the effects of centrifugation on stem cells present in adipose tissue. Liposuction aspirates were obtained from
Imaging myelinated nerve fibres by confocal fluorescence microscopy: individual fibres in whole nerve trunks traced through multiple consecutive internodes
Reynolds RJ, et al.
Journal of Neurocytology, 23(9), 555-564 (1994)
Yuan Qin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 663-675 (2020-01-10)
Mitochondrial fusion and fission are essential for heart function. Abrogating mitochondrial dynamism leads to cardiomyopathy. Excessive mitochondrial fragmentation is involved in most heart diseases, thus enhancing mitochondrial fusion will be a potential therapeutic strategy. To understand the effects of promoting
Zuzana Trebichalská et al.
Frontiers in cell and developmental biology, 9, 755740-755740 (2021-11-20)
The egg plays a pivotal role in the reproduction of our species. Nevertheless, its fundamental biology remains elusive. Transmission electron microscopy is traditionally used to inspect the ultrastructure of female gametes. However, two-dimensional micrographs contain only fragmentary information about the
Yan Lu et al.
STAR protocols, 2(2), 100515-100515 (2021-05-25)
This protocol describes how to prepare intact mouse cochleae for serial block-face scanning electron microscopy (SBEM). The detailed workflow includes cochlea fixation, en bloc staining, resin embedding, X-ray microscopy-guided trimming and SBEM data acquisition. This protocol allows large-scale, nanometer-resolution three-dimensional
Thomas M Fenton et al.
Immunity, 52(3), 557-570 (2020-03-12)
The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal
Flora Gilde et al.
Acta biomaterialia, 46, 55-67 (2016-09-17)
Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as an insoluble cue physically bound to a
Cytotoxic effect of three arsenic compounds in HeLa human tumor and bacterial cells
Abdullaev F, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 493(1), 31-38 (2001)
Tobias W Giessen et al.
eLife, 8 (2019-07-10)
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron. Encapsulins, a class
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