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Showing 1-30 of 60 results for "C1022" within Papers
Federica Sotgia et al.
The American journal of pathology, 174(2), 613-629 (2009-01-24)
Here, we show that functional loss of a single gene is sufficient to confer constitutive milk protein production and protection against mammary tumor formation. Caveolin-3 (Cav-3), a muscle-specific caveolin-related gene, is highly expressed in muscle cells. We demonstrate that Cav-3
Tao Qian et al.
Oncogene, 39(10), 2069-2087 (2019-12-06)
PINCH-1 is a cytoplasmic component of the cell-extracellular matrix (ECM) adhesion machine that is frequently overexpressed in cancer. The functions and mechanism of PINCH-1 in cancer, however, remain to be determined. Here, we show that PINCH-1 interacts with myoferlin, a
Shuxun Ren et al.
PloS one, 9(11), e111606-e111606 (2014-11-05)
We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress. In the present report, we found
A R Yallowitz et al.
Cell death and differentiation, 21(4), 645-654 (2014-01-21)
In embryogenesis, p63 is essential to develop mammary glands. In the adult mammary gland, p63 is highly expressed in the basal cell layer that comprises myoepithelial and interspersed stem/progenitor cells, and has limited expression in luminal epithelial cells. In adult
Juliane Strietz et al.
Oncotarget, 7(50), 83278-83293 (2016-11-10)
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular growth by processes other than apoptosis or cell division. We
Histophatologic Techniques null
Bing Tan et al.
Cancers, 12(9) (2020-08-23)
Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of latent factors. MMP11 is a negative regulator of adipose tissue development and
Chunyan Hu et al.
The American journal of pathology, 168(3), 973-990 (2006-03-02)
The mouse mammary tumor virus (MMTV) provirus was found to target the Notch1 gene, producing insertional mutations in mammary tumors of MMTV/neu transgenic (Tg) mice. In these mammary tumors, the Notch1 gene is truncated upstream of the transmembrane domain, and
David Llobet-Navas et al.
Genes & development, 28(7), 765-782 (2014-03-19)
The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the
Parisa Rabieifar et al.
Scientific reports, 9(1), 14436-14436 (2019-10-09)
p21-activated kinases (PAKs) are serine/threonine kinases functioning as downstream effectors of the small GTPases Rac1 and Cdc42. Members of the PAK family are overexpressed in human breast cancer, but their role in mammary gland development is not fully explored. Here
Petra Niessen et al.
Gastroenterology, 129(5), 1592-1601 (2005-11-16)
In patients with chronic intestinal pseudo-obstruction, intestinal motility is disturbed by either nervous or myogenic aberrations. The cause of the myogenic form is unknown, but it is likely to originate in the contractile apparatus of the smooth muscle cells. Smoothelins
Ajun Geng et al.
eLife, 9 (2020-08-05)
R-spondin1 (Rspo1) has been featured as a Wnt agonist, serving as a potent niche factor for stem cells in many tissues. Here we unveil a novel role of Rspo1 in promoting estrogen receptor alpha (Esr1) expression, hence regulating the output
Paul A Muller et al.
Science (New York, N.Y.), 370(6514), 314-321 (2020-08-29)
The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more
Alec N Woosley et al.
Oncogene, 38(20), 3794-3811 (2019-01-30)
FAM3C/Interleukin-like EMT Inducer (ILEI) is an oncogenic member of the FAM3 cytokine family and serves essential roles in both epithelial-mesenchymal transition (EMT) and breast cancer metastasis. ILEI expression levels are regulated through a non-canonical TGFβ signaling pathway by 3'-UTR-mediated translational
Michelle Cicchini et al.
Autophagy, 10(11), 2036-2052 (2014-12-09)
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss, and likely defective autophagy, in tumorigenesis. Recent studies have questioned the tumor suppressive role of autophagy, as autophagy-related gene (Atg) defects generally suppress
Ayan T Ray et al.
Genes & development, 34(23-24), 1735-1752 (2020-11-14)
FGFs are key developmental regulators that engage a signal transduction cascade through receptor tyrosine kinases, prominently engaging ERK1/2 but also other pathways. However, it remains unknown whether all FGF activities depend on this canonical signal transduction cascade. To address this
Improper chromosome synapsis is associated with elongated RAD51 structures in the maize desynaptic2 mutant.
Franklin AE, et al.
Chromosoma, 112, 17-17 (2003)
Naisi Li et al.
iScience, 24(6), 102508-102508 (2021-06-19)
Gut motility is regulated by the microbiome via mechanisms that include bile acid metabolism. To localize the effects of microbiome-generated bile acids, we colonized gnotobiotic mice with different synthetic gut bacterial communities that were metabolically phenotyped using a functional in vitro
Livia H Morais et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46(11), 1958-1968 (2021-05-28)
The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in early-life, alterations
Sonia de Assis et al.
Journal of visualized experiments : JoVE, (44), DOI: 10-DOI: 10 (2010-10-26)
Studies in rodent models of breast cancer show that exposures to dietary/hormonal factors during the in utero and pubertal periods, when the mammary gland undergoes extensive modeling and re-modeling, alter susceptibility to carcinogen-induced mammary tumors. Similar findings have been described
A M Touré et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 28(10), 1494-1507 (2016-06-10)
In Hirschsprung disease (HSCR), the absence of myenteric neural ganglia in the distal bowel prevents motility and thereby causes functional intestinal obstruction. Although surgical resection of the aganglionic segment allows HSCR children to survive this condition, a number of patients
Rosa Pascual et al.
Science advances, 6(20), eaax3868-eaax3868 (2020-05-23)
Organogenesis is directed by coordinated cell proliferation and differentiation programs. The hierarchical networks of transcription factors driving mammary gland development and function have been widely studied. However, the contribution of posttranscriptional gene expression reprogramming remains largely unexplored. The 3' untranslated
Ross Gray et al.
CBE life sciences education, 11(2), 180-186 (2012-06-06)
Phagocytosis and exocytosis are two cellular processes involving membrane dynamics. While it is easy to understand the purpose of these processes, it can be extremely difficult for students to comprehend the actual mechanisms. As membrane dynamics play a significant role
Natalie J Haywood et al.
EMBO reports, 22(5), e50767-e50767 (2021-05-03)
Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R)
Vladimir Grubišić et al.
Autism research : official journal of the International Society for Autism Research, 8(5), 629-633 (2015-03-03)
Pitt-Hopkins syndrome (PTHS) is a neurodevelopmental disorder, classified as an autism spectrum disorder that is caused by the haploinsufficiency of Transcription Factor 4 (TCF4). The most common non-neurological symptoms in PTHS patients are gastrointestinal (GI) disturbances, mainly gastroesophageal reflux and
Barbora Waclawiková et al.
PLoS biology, 19(1), e3001070-e3001070 (2021-01-23)
Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary supplement and antidepressant
Nathalie Vaes et al.
EMBO reports, 22(6), e51913-e51913 (2021-04-24)
The N-Myc Downstream-Regulated Gene 4 (NDRG4), a prominent biomarker for colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that nerves are important members of the tumor microenvironment, we here establish different Ndrg4 knockout (Ndrg4-/- ) CRC models and
Methods in Mammary Gland Biology and Breast Cancer Research (2000)
Chunling Tang et al.
Developmental biology, 455(1), 42-50 (2019-07-03)
Mammary glands are unique organs in which major adaptive changes occur in morphogenesis and development after birth. Breast cancer is the most common cancer and a major cause of mortality in females worldwide. We have previously identified the loss of
Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.
Williams TM, et al.
Molecular Biology of the Cell, 14, 1027-1027 (2003)
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