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Showing 1-30 of 116 results for "C1528" within Papers
Conservation. Drug policy as conservation policy: narco-deforestation.
Kendra McSweeney et al.
Science (New York, N.Y.), 343(6170), 489-490 (2014-02-01)
Andrew B Norman et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 311-315 (2013-12-07)
The change in frequency of cocaine self-administration as a function of the unit dose is widely assumed to represent a graded pharmacodynamic response. Alternatively, a pharmacological theory states that during maintained self-administration, a quantal response occurs at a minimum maintained
Yanhua H Huang et al.
Neuron, 80(4), 835-836 (2013-11-26)
Development of drug addiction is extremely complex, but its initiation can be as simple as the flip-flop of glutamatergic receptor subtypes triggered by an "unusual" type of NMDA receptors, as suggested by Yuan et al. (2013) in this issue of
Eric W Fish et al.
Psychopharmacology, 231(17), 3415-3423 (2014-05-09)
The neuroactive steroid (3Ī±,5Ī±)-3-hydroxy-pregnan-20-one (3Ī±,5Ī±-THP, allopregnanolone) has effects on reward-related behaviors in mice and rats that suggest that it may activate brain reward circuits. Intracranial self-stimulation (ICSS) is an operant behavioral technique that detects changes in the sensitivity of brain
Mami Otaka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6753-6758 (2013-04-19)
Medium spiny neurons (MSNs) within the nucleus accumbens shell (NAc) function to gate and prioritize emotional/motivational arousals for behavioral output. The neuronal output of NAc MSNs is mainly determined by the integration of membrane excitability and excitatory/inhibitory synaptic inputs. Whereas
Scott J Moeller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10027-10036 (2013-06-14)
Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with homozygote carriers of the 10R-allele) show heightened reactivity to drug-related reinforcement in addiction. Here, using
Hanjing Emily Wu et al.
The Journal of nervous and mental disease, 203(1), 33-36 (2014-12-10)
Despite the high prevalence of cocaine use disorder (CUD) in individuals with schizophrenia, current understanding of the effect of cocaine on psychiatric hospital length of stay (LOS) in individuals with schizophrenia is limited. We therefore retrospectively examined the medical records
Katherine Winter et al.
The Journal of family practice, 62(9), 503-505 (2013-10-02)
Was there a connection between our patient's drug use and the appearance of his ears, which were turning black?
Trachway in assistance of nasotracheal intubation with a preformed nasotracheal tube in patients undergoing oral maxillofacial surgery.
H-T Hsu et al.
British journal of anaesthesia, 113(4), 720-721 (2014-09-23)
CĆ©line Devroye et al.
Neuropharmacology, 89, 375-381 (2014-12-03)
The serotonin(2C) receptor (5-HT(2C)R) is known to control dopamine (DA) neuron function by modulating DA neuronal firing and DA exocytosis at terminals. Recent studies assessing the influence of 5-HT(2C)Rs on cocaine-induced neurochemical and behavioral responses have shown that 5-HT2CRs can
Liu Xue et al.
The Biochemical journal, 453(3), 447-454 (2013-07-16)
Cocaine is a widely abused drug without an FDA (Food and Drug Administration)-approved medication. It has been recognized that an ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway
James M Otis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 6057-6064 (2014-04-25)
Brain-derived neurotrophic factor (BDNF) regulates synaptic activity and behavioral flexibility, and reduction of BDNF strongly predicts psychiatric disorders and cognitive dysfunction. Restoration of BDNF-dependent activity could alleviate these impairments, but BDNF has limited clinical utility due to its pharmacokinetics. Here
An indirect resilience to addiction.
Marina R Picciotto
Nature neuroscience, 16(5), 521-523 (2013-04-27)
Shattuck Lecture. A molecular basis for nicotine as a gateway drug.
Eric R Kandel et al.
The New England journal of medicine, 371(10), 932-943 (2014-09-04)
Emmanuelle Jordi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9511-9516 (2013-05-22)
Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in striatal neurons. These changes are thought to participate in physiological memory mechanisms and to be critical for long-term behavioral
Ryan T Lacy et al.
Life sciences, 114(2), 86-92 (2014-08-19)
Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have
D Jantas et al.
Neuropharmacology, 83, 36-53 (2014-04-10)
Recent studies have documented that metabotropic glutamate receptors from group II and III (mGluR II/III) are a potential target in the symptomatic treatment of Parkinson's disease (PD), however, the neuroprotective effects of particular mGluR II/III subtypes in relation to PD
Kicheon Park et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(40), 15827-15836 (2013-10-04)
Dopamine increases triggered by cocaine and consequent stimulation of dopamine receptors (including D1 and D2) are associated with its rewarding effects. However, while facilitation of D1 receptor (D1R) signaling enhances the rewarding effects of cocaine, facilitation of D2R signaling decreases
John R Lever et al.
The Journal of pharmacology and experimental therapeutics, 351(1), 153-163 (2014-08-08)
Psychostimulant effects of cocaine are mediated partly by agonist actions at sigma-1 (Ļ1) receptors. Selective Ļ1 receptor antagonists attenuate these effects and provide a potential avenue for pharmacotherapy. However, the selective and high affinity Ļ1 antagonist PD144418 (1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine) has been
Lei Fang et al.
Chemico-biological interactions, 214, 18-25 (2014-03-04)
Cocaine is a widely abused and addictive drug without an FDA-approved medication. Our recently designed and discovered cocaine hydrolase, particularly E12-7 engineered from human butyrylcholinesterase (BChE), has the promise of becoming a valuable cocaine abuse treatment. An ideal anti-cocaine therapeutic
Rajeev I Desai et al.
The Journal of pharmacology and experimental therapeutics, 348(1), 106-115 (2013-11-07)
An N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3Ī±-[bis(4'-fluorophenyl)methoxy]-tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral effects and antagonizes various effects of cocaine. The present study further examined mechanisms underlying these effects. Cocaine dose-dependently increased locomotion, whereas JHW007 was
Nobuyoshi Suto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9050-9055 (2013-05-24)
While glutamate in the nucleus accumbens (NAS) contributes to the promotion of drug-seeking by drug-predictive cues, it also appears to play a role in the inhibition of drug-seeking following extinction procedures. Thus we measured extracellular fluctuations of NAS glutamate in
Xiaoqing Cai et al.
Journal of medicinal chemistry, 56(9), 3701-3709 (2013-05-01)
Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus terminating both psychoactive effects and drug toxicity. Herein, we report our efforts
L Skender et al.
Forensic science international, 125(2-3), 120-126 (2002-03-23)
Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in
Miriam Freundt et al.
The American journal of emergency medicine, 32(4), 395-395 (2013-12-18)
Severe hypothermia with a core temperature below 28Ā°C is critical especially in patients with diabetic ketoacidosis (DKA) and carries a high risk of mortality. Our case of a 52-year-old woman presenting with DKA, pH of 6.9, potassium of 7.6 mEq/L
Paola Devoto et al.
Addiction biology, 19(4), 612-622 (2013-01-08)
The dopamine-beta-hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement of cocaine seeking after extinction in rats. To clarify its mechanism of action, we examined the effect of nepicastat, given alone or in association with
Irena Kasacka et al.
Experimental biology and medicine (Maywood, N.J.), 239(10), 1292-1299 (2014-06-19)
Taking into consideration the homeostatic disorders resulting from renal hypertension and the essential role of cocaine- and amphetamine-regulated transcript (CART) in maintaining homeostasis by regulating many functions of the body, the question arises as to what extent the renovascular hypertension
StƩphanie Puig et al.
Psychopharmacology, 231(16), 3131-3137 (2014-02-22)
Chronic exposure to drugs of abuse induces important modifications on neuronal systems. Increasing evidence shows that the consequences to chronic cocaine exposure can be different depending on the administration pattern. The aim of the present study was to evaluate the
Kevin B Freeman et al.
Psychopharmacology, 231(12), 2395-2403 (2014-01-09)
Recent research has demonstrated that the drug, histamine, can function as a punisher of cocaine self-administration. However, little is known about how drug punishers affect the maximum reinforcing effectiveness of drugs as reinforcers. The goal of the present study was
Magdalena Zaniewska et al.
Pharmacological reports : PR, 66(2), 205-211 (2014-06-10)
Male Wistar rats were used to verify the hypothesis that metabotropic glutamate 4 (mGlu4) receptor ligands may modulate the locomotor effects evoked by cocaine or nicotine. The preferential mGlu4 receptor orthosteric agonist (2S)-2-amino-4-[hydroxy[hydroxy(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid (LSP1-2111) and the mGlu4 receptor positive
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