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Showing 1-30 of 73 results for "C1821" within Papers
Stefan Kurtenbach et al.
Scientific reports, 7(1), 8409-8409 (2017-08-18)
BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause severe immune deficiency.
Joseph O Humtsoe et al.
Molecular and cellular biology, 30(7), 1593-1606 (2010-02-04)
Endothelial cell (EC) migration, cell-cell adhesion, and the formation of branching point structures are considered hallmarks of angiogenesis; however, the underlying mechanisms of these processes are not well understood. Lipid phosphate phosphatase 3 (LPP3) is a recently described p120-catenin-associated integrin
Lena Tveriakhina et al.
eLife, 7 (2018-10-06)
DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1 and NOTCH2 differently in cell-based
Peter Büchler et al.
Annals of surgery, 242(6), 791-800 (2005-12-06)
To analyze the potential role of the Notch signaling pathway in pancreatic cancer angiogenesis and invasion. Angiogenesis, pain, and early neuroinvasion are clinical features of pancreatic cancer. Blood vessels and nerves develop together and use common routes through the organism.
Elena Taverna et al.
Scientific reports, 6, 21206-21206 (2016-02-18)
Apical radial glia (aRG), the stem cells in developing neocortex, are unique bipolar epithelial cells, extending an apical process to the ventricle and a basal process to the basal lamina. Here, we report novel features of the Golgi apparatus, a
I M S Paulsen et al.
European journal of histochemistry : EJH, 59(4), 2532-2532 (2015-12-29)
Heat-induced epitope retrieval (HIER) is widely used for immunohistochemistry on formalin fixed paraffin-embedded tissue and includes temperatures well above the melting point of paraffin. We therefore tested whether traditional xylene-based removal of paraffin is required on sections from paraffin-embedded tissue
Jun Arii et al.
Journal of virology, 89(3), 1879-1888 (2014-11-28)
Nonmuscle myosin heavy chain IIA (NMHC-IIA) has been reported to function as a herpes simplex virus 1 (HSV-1) entry coreceptor by interacting with viral envelope glycoprotein B (gB). Vertebrates have three genetically distinct isoforms of the NMHC-II, designated NMHC-IIA, NMHC-IIB
Elise Peter et al.
Neurology(R) neuroimmunology & neuroinflammation, 9(5) (2022-08-09)
There is no report on the long-term outcomes of ataxia with antibodies against Delta and Notch-like epidermal growth factor-related (DNER). We aimed to describe the clinical-immunologic features and long-term outcomes of patients with anti-DNER antibodies. Patients tested positive for anti-DNER
Sung Jun Bae et al.
eLife, 6 (2017-10-25)
The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex
Florian Bakoa et al.
NPJ vaccines, 6(1), 64-64 (2021-04-28)
Mass vaccination with the live attenuated vaccine YF-17D is the current way to prevent infection with Yellow fever virus (YFV). However, 0.000012-0.00002% of vaccinated patients develop post-vaccination neurological syndrome (YEL-AND). Understanding the factors responsible for neuroinvasion, neurotropism, and neurovirulence of
Nathan J Palpant et al.
PloS one, 10(5), e0126259-e0126259 (2015-05-16)
Maternal smoking is a risk factor for low birth weight and other adverse developmental outcomes. We sought to determine the impact of standard tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo. Zebrafish (Danio rerio) were used
Chau-Fu Cheng et al.
The Journal of comparative neurology, 524(4), 846-873 (2015-08-05)
Subthreshold A-type K(+) currents (ISA s) have been recorded from the somata of nociceptors and spinal lamina II excitatory interneurons, which sense and modulate pain, respectively. Kv4 channels are responsible for the somatodendritic ISA s. Accumulative evidence suggests that neuronal
Victor Baeza et al.
Scientific reports, 11(1), 18537-18537 (2021-09-19)
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such as supratentorial anaplastic ependymomas, which
Yi Li et al.
Cancer biology & therapy, 15(4), 428-435 (2014-01-23)
The transcription factor GATA3 is known as a breast tumor suppressor as well as a urothelial marker, and its loss is often seen in high-grade invasive bladder cancer. Nonetheless, GATA3 functions in bladder cancer cells remain largely unknown. In this
Marta Segarra et al.
Science (New York, N.Y.), 361(6404) (2018-08-25)
The architecture of the neurovascular unit (NVU) is controlled by the communication of neurons, glia, and vascular cells. We found that the neuronal guidance cue reelin possesses proangiogenic activities that ensure the communication of endothelial cells (ECs) with the glia
Jan A Kullmann et al.
Cerebral cortex (New York, N.Y. : 1991), 30(6), 3467-3482 (2019-12-24)
Neocortex development depends on neural stem cell proliferation, cell differentiation, neurogenesis, and neuronal migration. Cytoskeletal regulation is critical for all these processes, but the underlying mechanisms are only poorly understood. We previously implicated the cytoskeletal regulator profilin1 in cerebellar granule
Filippo Casoni et al.
Development (Cambridge, England), 144(20), 3686-3697 (2017-09-13)
The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations are associated with Joubert Syndrome, a ciliopathy causing cerebellar vermis hypoplasia and ataxia.
Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation
Chung H, et al.
Biochemical and Biophysical Research Communications (2018)
Qi Yang et al.
Annals of neurology, 77(4), 618-636 (2015-01-23)
Fragile X syndrome (FXS) is a form of inherited mental retardation in humans that results from expansion of a CGG repeat in the FMR1 gene. Interaction between estrogen receptor (ER) and lipid raft caveolae is critical for the estrogen signaling.
T P de Boer et al.
British journal of pharmacology, 159(7), 1532-1541 (2010-02-26)
Pentamidine is a drug used in treatment of protozoal infections. Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias associated with QTc prolongation and U-wave alterations. This proarrhythmic effect was linked to inhibition of hERG trafficking, but not
Bobae An et al.
eLife, 6 (2017-07-04)
There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction.
Fergil Mills et al.
Nature neuroscience, 20(4), 540-549 (2017-02-14)
Drugs of abuse alter synaptic connections in the reward circuitry of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes
Pawel K Olszewski et al.
PLoS genetics, 8(3), e1002568-e1002568 (2012-03-23)
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea
N-cadherin is key to expression of the nucleus pulposus cell phenotype under selective substrate culture conditions
Hwang PY, et al.
Scientific Reports, 6(11), 28038-28038 (2016)
Yu-Ting Mao et al.
Neural plasticity, 2013, 530651-530651 (2013-11-30)
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex. In previous research, we found that auditory cortical tuning and tonotopy were impaired by cross-modal invasion of
Rieko Ajima et al.
PloS one, 12(11), e0187248-e0187248 (2017-11-03)
The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-fucosyltransferase1 (Pofut1)
Alvaro Souto Padron de Figueiredo et al.
The Journal of biological chemistry, 290(21), 13427-13439 (2015-04-01)
Inflammation and oxidative stress through the production of reactive oxygen species (ROS) are consistently associated with metabolic syndrome/type 2 diabetes. Although the role of Nox2, a major ROS-generating enzyme, is well described in host defense and inflammation, little is known
Rossana Bongianino et al.
Circulation research, 121(5), 525-536 (2017-06-18)
Mutations in the cardiac Ryanodine Receptor gene ( We investigated the efficacy of allele-specific silencing by RNA interference to prevent CPVT phenotypic manifestations in our dominant CPVT mice model carriers of the heterozygous mutation R4496C in We developed an in
Veronica Maillo et al.
Reproduction (Cambridge, England), 152(1), 37-46 (2016-04-14)
The aim of this study was to compare the transcriptome of the oviductal isthmus of pregnant heifers with that of cyclic heifers as well as to investigate spatial differences between the transcriptome of the isthmus and ampulla of the oviduct
Masahiko Hirano et al.
Nature biotechnology, 40(7), 1132-1142 (2022-04-27)
The low photostability of fluorescent proteins is a limiting factor in many applications of fluorescence microscopy. Here we present StayGold, a green fluorescent protein (GFP) derived from the jellyfish Cytaeis uchidae. StayGold is over one order of magnitude more photostable
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