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Showing 1-30 of 87 results for "C1889" within Papers
Andreas Zollner et al.
Journal of Crohn's & colitis, 15(1), 43-54 (2020-06-20)
Faecal biomarkers, particularly calprotectin [FCAL], have become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As FCAL is mainly produced by neutrophils, we hypothesised that faecal lipocalin-2 [FLCN2], also expressed by intestinal epithelial cells [IEC], could be beneficial
Ulrike Träger et al.
Neurobiology of disease, 73, 388-398 (2014-12-03)
Inflammation is a growing area of research in neurodegeneration. In Huntington's disease (HD), a fatal inherited neurodegenerative disease caused by a CAG-repeat expansion in the gene encoding huntingtin, patients have increased plasma levels of inflammatory cytokines and circulating monocytes that
R Foissac et al.
Chirurgie de la main, 32(4), 199-205 (2013-07-17)
Dupuytren's disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No
Fanny Guimont-Desrochers et al.
Journal of immunology (Baltimore, Md. : 1950), 182(9), 5193-5197 (2009-04-22)
The combined phenotypic expression of CD11c(low)B220(+)CD122(+)DX5(+) has been used to define a novel cell type termed IFN-producing killer dendritic cells (IKDC). IKDC readily produce IFN-gamma and demonstrate spontaneous cytotoxic activity toward tumors, suggesting that a modulation of IKDC number may
Martin Gelbard et al.
The Journal of urology, 187(6), 2268-2274 (2012-04-17)
Collagenase Clostridium histolyticum is an investigational nonsurgical treatment for Peyronie disease. In this phase 2b, double-blind, randomized, placebo controlled study we determined the safety and efficacy of collagenase C. histolyticum and assessed a patient reported outcome questionnaire. A total of
Stine M Præstholm et al.
Cell reports, 37(5), 109938-109938 (2021-11-04)
The transition from a fasted to a fed state is associated with extensive transcriptional remodeling in hepatocytes facilitated by hormonal- and nutritional-regulated transcription factors. Here, we use a liver-specific glucocorticoid receptor (GR) knockout (L-GRKO) model to investigate the temporal hepatic
V Secq et al.
Cell death & disease, 6, e1592-e1592 (2015-01-16)
Pancreatic ductal adenocarcinoma (PDA) is a critical health issue in the field of cancer, with few therapeutic options. Evidence supports an implication of the intratumoral microenvironment (stroma) on PDA progression. However, its contribution to the role of neuroplastic changes within
K K Makinen et al.
The Journal of biological chemistry, 262(26), 12488-12495 (1987-09-15)
The major collagenolytic proteinase present in the culture filtrate of Bacillus cereus (strain Soc 67, isolated from the human oral cavity) has been purified to homogeneity by a procedure that comprised concentration of ultrafiltered growth medium on a Millipore PTTK00005
Farhatullah Syed et al.
PloS one, 7(2), e31430-e31430 (2012-03-03)
Dupuytren's disease (DD) is a benign, fibroproliferative disease of the palmar fascia, with excessive extracellular matrix (ECM) deposition and over-production of cytokines and growth factors, resulting in digital fixed flexion contractures limiting hand function and patient quality of life. Surgical
Weizu Li et al.
Scientific reports, 7(1), 4145-4145 (2017-06-25)
The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs). GFR was assessed in conscious TRPC6 wild type and knockout mice, and in anesthetized rats with and
Elsa Hadj Bachir et al.
Biology of the cell, 114(1), 32-55 (2021-09-26)
Although improvements have been made in the management of pancreatic adenocarcinoma (PDAC) during the past 20 years, the prognosis of this deadly disease remains poor with an overall 5-year survival under 10%. Treatment with FOLFIRINOX, a combined regimen of 5-fluorouracil
Markus Vogt et al.
Theranostics, 11(11), 5569-5584 (2021-04-17)
Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, including gastric electrical stimulation, are non-satisfying and may improve symptoms
Bacterial artificial chromosomes (BACs)-on-Beads? as a diagnostic platform for the rapid aneuploidy screening of products of conception
Sheath KL, et al.
Molecular Medicine Reports, 8(2), 650-654 (2013)
Shotaro Uehara et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(6), 678-687 (2018-07-04)
The evaluation of drug-mediated cytochrome P450 (P450) induction using human hepatocytes is important for predicting drug interactions. In this study, we prepared hepatocytes from chimeric mice with humanised livers (Hu-Liver mice) and evaluated the expression and inducibility of P450s in
Aliyah M Weinstein et al.
Oncoimmunology, 6(6), e1322238-e1322238 (2017-07-07)
We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy in association with the development of structures resembling tertiary lymphoid organs (TLO) in
Stephen Coleman et al.
BMC musculoskeletal disorders, 13, 61-61 (2012-05-01)
Dupuytren's contracture (DC) is a progressive fibroproliferative disorder characterized by development of nodules and collagen cords within the palmar fascia of the hand. Collagenase clostridium histolyticum (CCH) is currently approved in adults with DC for the nonsurgical treatment of a
Marloes Zoetemelk et al.
Molecular oncology, 14(11), 2894-2919 (2020-10-07)
The current standard of care for colorectal cancer (CRC) is a combination of chemotherapeutics, often supplemented with targeted biological drugs. An urgent need exists for improved drug efficacy and minimized side effects, especially at late-stage disease. We employed the phenotypically
Li Qiao et al.
The Journal of clinical investigation, 129(6), 2237-2250 (2019-04-30)
Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the reparative properties of their parental cells. The constitution of exosomes, as well as their biological activity, largely depends on the cells that secrete them. We isolated exosomes from
A N Balamurugan et al.
Transplantation, 93(7), 693-702 (2012-02-10)
The optimal enzyme blend that maximizes human islet yield for transplantation remains to be determined. In this study, we evaluated eight different enzyme combinations (ECs) in an attempt to improve islet yield. The ECs consisted of purified, intact or truncated
Chen Zhang et al.
Cell biology international, 46(9), 1423-1432 (2022-07-12)
Tympanosclerosis (TS) is a result of long-standing middle ear inflammation characterized by fibroblasts ossification. Fibrosis is the last revertible stage in the progress of middle ear inflammation to TS. It was hypothesized that chronic hypoxia could be modulating fibrosis, which
Ahmed Reda et al.
Frontiers in endocrinology, 5, 21-21 (2014-03-13)
Although three-dimensional testicular cell cultures have been demonstrated to mimic the organization of the testis in vivo and support spermatogenesis, the optimal culture conditions and requirements remain unknown. Therefore, utilizing an established three-dimensional cell culture system that promotes differentiation of
Beware of the small finger and/or the proximal interphalangeal joint? Skin lacerations following collagenase injection in dupuytren contracture.
Karsten Knobloch et al.
Plastic and reconstructive surgery, 130(1), 202e-204e (2012-06-30)
H E Van Wart et al.
Biochemistry, 24(23), 6520-6526 (1985-11-05)
The substrate specificities of three class I (beta, gamma, and eta) and three class II (sigma, epsilon, and zeta) collagenases from Clostridium histolyticum have been investigated by quantitating the kcat/KM values for the hydrolysis of 53 synthetic peptides with collagen-like
Clayton A Peimer et al.
The Journal of hand surgery, 38(1), 12-22 (2012-12-04)
To evaluate long-term efficacy and safety of collagenase clostridium histolyticum (CCH) after the third year of a 5-year nontreatment follow-up study, Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study. This study enrolled Dupuytren contracture patients from 5
Preparation of isolated rat liver cells.
P O Seglen
Methods in cell biology, 13, 29-83 (1976-01-01)
Ask the doctor. I have Dupuytren's contracture in both hands. I've had "needle" surgery in one hand, and the fingers straightened. But they seem to want to contract again. What can I do?
Celeste Robb-Nicholson
Harvard women's health watch, 19(5), 7-7 (2012-03-09)
Yan-Hua Sang et al.
Experimental animals, 62(1), 63-69 (2013-01-30)
A combination of hematoma aspiration and local delivery of chemicals may be more effective than either therapy in intracerebral hemorrhage (ICH). The aim of the present study was to develop a rat model of hematoma aspiration plus intralesional injection after
Oren Sarig et al.
Harefuah, 153(1), 19-21 (2014-03-13)
Dupuytren's disease is a fibromatosis affecting the hand. The disease affects the hand and fingers and may present with a contracture causing increasing disability of the hand. We can treat the symptoms but not its cause. In this article we
Zhaohua Shen et al.
EBioMedicine, 85, 104285-104285 (2022-10-02)
Crohn's disease (CD) is a chronic inflammatory disorder characterized by intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the pathogenesis of CD. However, the effect of commensal bacteria on controlling the inflammatory response in individuals with CD
Bernhard Texler et al.
Cellular and molecular gastroenterology and hepatology, 13(2), 383-404 (2021-10-09)
By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in ulcerative colitis many aspects concerning its mode of
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