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Showing 1-18 of 18 results for "C1956" within Papers
Y Oishi et al.
Acta physiologica (Oxford, England), 192(3), 381-395 (2007-09-26)
We used a model of chronic unloading followed by reloading to examine the apoptotic responses associated with soleus muscle atrophy and subsequent recovery. Male Wistar rats were subjected to hindlimb unloading (HU) for 2 weeks and subsequent reloading for 0
Jolene M Kim et al.
Neurochemical research (2018-01-05)
Impaired interactions between Calcineurin (Cn) and (Cu/Zn) superoxide dismutase (SOD1) are suspected to be responsible for the formation of hyperphosphorylated protein aggregation in amyotrophic lateral sclerosis (ALS). Serine (Ser)- enriched phosphorylated TDP-43 protein aggregation appears in the spinal cord of
Yan-Li Wang et al.
Cancer science, 99(6), 1100-1108 (2008-04-22)
Calcineurin (CaN) is a Ca(2+)/calmodulin (CaM)-stimulated protein phosphatase. It is a heterodimeric enzyme consisting of a catalytic A subunit (CnA) and a Ca(2+)-binding regulatory B subunit (CnB). CaN's key role in vivo is well known, while the function of CnB
Anindit Mukherjee et al.
American journal of physiology. Renal physiology, 320(5), F719-F733 (2021-03-16)
Phosphorylation of the thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted tubule (DCT) is altered rapidly in response to changes in extracellular K+ concentration ([K+]). High extracellular [K+] is believed to activate specific phosphatases to dephosphorylate NCC, thereby reducing its
Jing Li et al.
Immunology letters, 140(1-2), 52-58 (2011-07-05)
Protective immunity involves a dynamic balance between humoral and cellular immune responses. In the present work we demonstrated that recombinant human calcineurin subunit B (rhCnB) stimulated the expression of the surface molecules CD83, CD80, CD86, CD40, and HLA-DR. It also
Impaired CuZn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue
Kim Jm, et al.
Neurochemical Research, 44(1), 228-233 (2019)
Maya Fujita et al.
Biological & pharmaceutical bulletin, 41(5), 786-796 (2018-05-02)
Although calcineurin is abundantly expressed in the nervous system and involved in neurite extension and synaptic plasticity in neurons, little is known about its roles in glial cells. To investigate the roles of calcineurin in glial cells, we generated glial
Colin Rickman et al.
The Journal of biological chemistry, 279(13), 12574-12579 (2004-01-08)
Synaptotagmins are membrane proteins that possess tandem C2 domains and play an important role in regulated membrane fusion in metazoan organisms. Here we show that both synaptotagmins I and II, the two major neuronal isoforms, can interact with the syntaxin/synaptosomal-associated
Yasuko Hirakawa et al.
Journal of molecular signaling, 4, 6-6 (2009-09-04)
Glucocorticoid hormones (GCs) induce apoptosis of leukemic T-cells by transcriptional regulation via the GC receptor, GR. In the human leukemic CEM cell culture model, RCAN1 has been identified as one of the genes that is specifically upregulated only in the
C A Stratakis et al.
DNA sequence : the journal of DNA sequencing and mapping, 9(4), 227-230 (1999-10-16)
Calcineurin is a protein phosphatase with an important role in signal transduction; its calcium-binding regulatory subunit, calcineurin B, is widely present in the brain and is coded by the PPP3R1 gene which was mapped recently to human chromosome 2. Calcineurin
Chiara Scaramuzzino et al.
Science advances, 8(1), eabj8812-eabj8812 (2022-01-06)
When a neurotrophin binds at the presynapse, it sends survival signals all the way to the nucleus on signaling endosomes. These endosomes fuel their own journey with on-board glycolysis—but how is that journey initiated and maintained? Using microfluidic devices and
H Bito et al.
Cell, 87(7), 1203-1214 (1996-12-27)
While changes in gene expression are critical for many brain functions, including long-term memory, little is known about the cellular processes that mediate stimulus-transcription coupling at central synapses. In studying the signaling pathways by which synaptic inputs control the phosphorylation
Akitoshi Nakashima et al.
Autophagy, 16(10), 1771-1785 (2019-12-21)
The etiology of preeclampsia (PE), a serious pregnancy complication, remains an enigma. We have demonstrated that proteinopathy, a pathologic feature of neurodegenerative diseases, is a key observation in the placenta and serum from PE patients. We hypothesize that the macroautophagy/autophagy
Ruth Hendus-Altenburger et al.
Nature communications, 10(1), 3489-3489 (2019-08-04)
Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na+/H+-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated by the Ser/Thr phosphatase calcineurin (CN). NHE1 activity is
L Tůmová et al.
Animal : an international journal of animal bioscience, 10(12), 1998-2007 (2016-05-11)
Calcineurin is required for oocyte exit from meiotic block in metaphase II (MII) stage in invertebrates and also in lower vertebrates. However, the role of calcineurin in mammalian oocyte activation is still unclear. The aim of this study was to
Lukasz Majewski et al.
International journal of molecular sciences, 21(3) (2020-02-06)
The maintenance of proper cytosolic Ca2+ level is crucial for neuronal survival, and dysregulation of Ca2+ homeostasis is found in a variety of neurological disorders, including Alzheimer's disease. According to the "Ca2+ hypothesis of aging", Ca2+ disturbances precede the onset
H Nishio et al.
Histochemistry and cell biology, 114(1), 9-14 (2000-08-26)
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, plays an important role in various physiological functions including T cell activation. This enzyme is a target molecule for the immunosuppressants, cyclosporin A and FK506. In the present study, we investigated immunohistochemical localization of calcineurin
Yasuharu Oishi et al.
Muscle & nerve, 52(6), 1047-1056 (2015-04-23)
We investigated heat-stress effects on the adult myosin heavy chain (MyHC) profile of soleus muscle fibers at an early stage of regeneration. Regenerating fibers in adult rats were analyzed 2, 4, or 6 days after bupivacaine injection. Rats were heat
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