C2888

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Showing 1-30 of 95 results for "C2888" within Papers

Determination of cholinesterase in blood and tissue.

Barry W Wilson et al.

Current protocols in toxicology, Chapter 12, Unit12-Unit12 (2007-11-01)

The widespread use of organophosphate and organocarbamate pesticides and the dangers of related chemical warfare agents dramatize the importance of rapid, accurate, and sensitive assays for blood and tissue cholinesterases (ChEs), important targets for neurotoxic chemicals. Two ChE enzymes used

7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.

Katarina Spilovska et al.

Molecules (Basel, Switzerland), 18(2), 2397-2418 (2013-02-23)

A structural series of 7-MEOTA-adamantylamine thioureas was designed, synthesized and evaluated as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). The compounds were prepared based on the multi-target-directed ligand strategy with different linker lengths (n = 2-8) joining the

Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.

C A ZITTLE et al.

Archives of biochemistry and biophysics, 56(2), 469-475 (1955-06-01)

Neuroprotective effect of phospholipase A2 from Malaysian Naja sumatrana venom against H2O2-induced cell damage and apoptosis.

Nur Atiqah Haizum Abdullah et al.

Frontiers in pharmacology, 13, 935418-935418 (2022-11-01)

Oxidative stress is one of the factors involved in the pathogenesis of several neurodegenerative diseases. It has been reported that a secretory phospholipase A2 known as A2-EPTX-NSm1a has lower cytotoxicity in neuronal cells compared to its crude Naja sumatrana venom.

Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease.

Vladimirs Pilipenko et al.

European journal of pharmacology, 881, 173290-173290 (2020-06-25)

The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline. The safest antidiabetic drug metformin has shown both glucose metabolism-improving and cognition-enhancing action in type 2 diabetes patients and

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

M D Wilson et al.

Nucleic acids research, 29(6), 1352-1365 (2001-03-10)

Chromosome 7q22 has been the focus of many cytogenetic and molecular studies aimed at delineating regions commonly deleted in myeloid leukemias and myelodysplastic syndromes. We have compared a gene-dense, GC-rich sub-region of 7q22 with the orthologous region on mouse chromosome

Comparison of biochemical and molecular tests for detecting insecticide resistance due to insensitive acetylcholinesterase in Culex quinquefasciatus.

Mariah L Scott et al.

Journal of the American Mosquito Control Association, 28(4), 323-326 (2013-02-12)

Insecticide resistance to organophosphates and carbamates can be the result of changes in acetylcholinesterase activity conferred by the ACE-1 mutation. Detection of this altered target site mutation is important in guiding informed decisions for resistance management. In this study we

Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma).

Lianguo Chen et al.

Aquatic toxicology (Amsterdam, Netherlands), 149, 116-125 (2014-03-04)

This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingredient used in the commercial antifoulant SeaNine 211, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) was employed as

Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors.

Belgin Sever et al.

International journal of biological macromolecules, 163, 1970-1988 (2020-09-16)

Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase (AChE) inhibitors in AD treatment has been well-documented so

Capillary electrophoretic enzyme assays.

Gerhard K E Scriba et al.

Methods in molecular biology (Clifton, N.J.), 984, 285-308 (2013-02-07)

In the past years, capillary electrophoresis has become a frequently used technique for enzyme assays due to the high separation efficiency and versatility as well as small sample size and low consumption of chemicals. The capillary electrophoresis assays can be

Protection against paraoxon toxicity by an intravenous pretreatment with polyethylene-glycol-conjugated recombinant butyrylcholinesterase in macaques.

Yvonne J Rosenberg et al.

Chemico-biological interactions, 210, 20-25 (2014-01-05)

Recombinant (r) butyrylcholinesterase (rBChE) produced in CHO cells is being developed as a prophylactic countermeasure against neurotoxicity resulting from exposure to organophosphates (OPs) in the form of pesticides and nerve agents. To evaluate the efficacy of a parenteral pretreatment, a

Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso.

Rachel M Kwiatkowska et al.

Gene, 519(1), 98-106 (2013-02-06)

With the exception of target site mutations, insecticide resistance mechanisms in the principle malaria vector Anopheles gambiae, remains largely uncharacterized in Burkina Faso. Here we detected high prevalence of resistance in Vallée du Kou (VK) to pyrethroids, DDT and dieldrin

In silico studies, nitric oxide, and cholinesterases inhibition activities of pyrazole and pyrazoline analogs of diarylpentanoids.

Siti Munirah Mohd Faudzi et al.

Archiv der Pharmazie, 354(1), e2000161-e2000161 (2020-09-05)

A new series of pyrazole, phenylpyrazole, and pyrazoline analogs of diarylpentanoids (excluding compounds 3a, 4a, 5a, and 5b) was pan-assay interference compounds-filtered and synthesized via the reaction of diarylpentanoids with hydrazine monohydrate and phenylhydrazine. Each analog was evaluated for its

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

A Shafferman et al.

The Journal of biological chemistry, 267(25), 17640-17648 (1992-09-05)

Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Of 20 amino acid positions mutated so far in human acetylcholinesterase (AChE), these

The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.

B Velan et al.

The Journal of biological chemistry, 266(35), 23977-23984 (1991-12-15)

Site-directed mutagenesis was used to study the cysteine residue involved in the assembly of human acetylcholinesterase (HuAChE) catalytic subunits. Substitution of the cysteine at position 580 by alanine resulted in impairment of interchain disulfide bridge formation; the mutagenized enzyme (C580A)

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity.

Fouad H Darras et al.

Biochemical and biophysical research communications, 489(4), 451-454 (2017-06-03)

Defined as a state function representing an inhibitor's absolute affinity for its target enzyme, the experimentally determined enzyme inhibition constant (K

The enzymic hydrolysis and synthesis of acetylcholine.

D NACHMANSOHN et al.

Advances in enzymology and related subjects of biochemistry, 12, 259-339 (1951-01-01)

Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones.

Silvia Olivera et al.

Molecular and cellular neurosciences, 23(1), 96-106 (2003-06-12)

Here we show that chronic application of low concentrations (0.01-0.05 U/ml) or a single application of 1-5 U/ml acetylcholinesterase (AChE) promotes the extension of neuronal processes, synapse formation, and alpha-amino-3-hydroxy-5-methylisoxazolepropionate receptor (AMPAR) surface expression in both embryonic and postnatal hippocampal

Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation.

Daniela Pereira et al.

Marine drugs, 19(1) (2020-12-31)

Over the last decades, antifouling coatings containing biocidal compounds as active ingredients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosylated flavones obtained by synthesis displayed antifouling activity

Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones.

Joana R Almeida et al.

Biomolecules, 10(8) (2020-08-06)

The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Toshio Ota et al.

Nature genetics, 36(1), 40-45 (2004-01-01)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to

Elevated temperatures increase the toxicity of pesticide mixtures to juvenile coho salmon.

Cathy A Laetz et al.

Aquatic toxicology (Amsterdam, Netherlands), 146, 38-44 (2013-11-26)

Pesticide mixtures and elevated temperatures are parallel freshwater habitat stressors for Pacific salmon in the western United States. Certain combinations of organophosphate (OP) insecticides are known to synergistically increase neurotoxicity in juvenile salmon. The chemicals interact to potentiate the inhibition

Colonic perforation in a case of adult Hirschsprung's disease with acetylcholinesterase-negative neuronal fibers.

Naruhiko Ikoma et al.

The American surgeon, 79(3), E130-E132 (2013-03-07)

External and internal electrostatic potentials of cholinesterase models.

C E Felder et al.

Journal of molecular graphics & modelling, 15(5), 318-327 (1998-06-26)

The electrostatic potentials for the three-dimensional structures of cholinesterases from various species were calculated, using the Delphi algorithm, on the basis of the Poisson-Boltzmann equation. We used structures for Torpedo californica and mouse acetylcholinesterase, and built homology models of the

[Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].

M A Iudin et al.

Eksperimental'naia i klinicheskaia farmakologiia, 76(2), 3-5 (2013-05-02)

The effect of memantine administration has been studied on the model of mice poisoning with an anticholinesterase compound. It is established that the memantine action is due to its influence on the cholinesterase activity in the brain, blood plasma, and

Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors.

Qëndresa Istrefi et al.

Archiv der Pharmazie, 353(6), e1900383-e1900383 (2020-04-15)

In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. All compounds were tested for their ability to inhibit the human carbonic

Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.

A D Nikitashina et al.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 449, 82-84 (2013-05-09)

Degradation, residual determination, and cholinesterase activity of triclorfon in Piaractus mesopotamicus Holmberg (PACU) 1887.

Maria Isabel Mataqueiro et al.

Journal of toxicology and environmental health. Part A, 77(1-3), 125-132 (2014-02-22)

The aim of this study was to determine the no-observable-adverse-effect concentration (NOAEC) for trichlorfon, an antiparasitic agent used in aquaculture, in Piractus mesopotamicus (pacu) using acetylcholinesterase (AChE) activity as an end point. Fish were exposed 24 h/d for 15 d

Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity.

Muhammet Serhat Özaslan et al.

Chemistry & biodiversity, 19(8), e202200280-e202200280 (2022-07-08)

In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe3+ and Cu2+ reductive ability and Fe2+ chelating effects. The inhibitory effects

Attenuation of erythrocytic acetyl cholinesterase by paracetamol and chloroquine: evidence in an in vitro study.

Shafiq Ahmad Tariq et al.

Pakistan journal of pharmaceutical sciences, 27(2), 261-264 (2014-03-01)

The present study deals with the erythrocytic acetylcholinesterase inhibitory activity of paracetamol and chloroquine in an in vitro protocol using Michaelis Menten parameters (Apparent Michaelis Constant (aKm) and Apparent Maximum Velocity (aVm). Paracetamol showed marked inhibition of the erythrocytic acetylcholinesterase.

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