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Showing 1-30 of 361 results for "C3915" within Papers
S Sahin et al.
European review for medical and pharmacological sciences, 17(7), 958-963 (2013-05-04)
Familial Mediterranean fever is an auto-inflammatory disorder. Long term complications of the disease include decreased quality of life. The measurement of quality of life in the patients with chronic disease has become an important research topic during the last years.
A randomized trial of colchicine for acute pericarditis.
Massimo Imazio et al.
The New England journal of medicine, 370(8), 781-781 (2014-02-21)
Jenny M Pedersen et al.
Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07)
The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and drug-like compounds. The data set included a new reference set
Spyridon Deftereos et al.
Journal of the American College of Cardiology, 61(16), 1679-1685 (2013-03-19)
This study sought to test the hypothesis that colchicine treatment after percutaneous coronary intervention (PCI) can lead to a decrease in in-stent restenosis (ISR). ISR rates are particularly high in certain patient subsets, including diabetic patients, especially when a bare-metal
Mallinath B Hadimani et al.
Journal of natural products, 76(9), 1668-1678 (2013-09-11)
The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, and they have inspired the design and synthesis of a large number of small-molecule, potential anticancer agents. The indole-based molecular scaffold is prominent among these SAR modifications
Aleem Gangjee et al.
Journal of medicinal chemistry, 50(14), 3290-3301 (2007-06-15)
We have discovered a novel series of 7-benzyl-4-methyl-5-[(2-substituted phenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amines, which possess antimitotic and antitumor activities against antimitotic-sensitive as well as resistant tumor cells. These agents bind to a site on tubulin that is distinct from the colchicine, vinca alkaloid, and
Eva Cabet et al.
PloS one, 10(9), e0137009-e0137009 (2015-09-04)
Desminopathies, a subgroup of myofibrillar myopathies (MFMs), the progressive muscular diseases characterized by the accumulation of granulofilamentous desmin-positive aggregates, result from mutations in the desmin gene (DES), encoding a muscle-specific intermediate filament. Desminopathies often lead to severe disability and premature
A D Caperta et al.
Protoplasma, 227(2-4), 147-153 (2006-03-08)
The microtubule cytoskeleton plays a crucial role in the cell cycle and in mitosis. Colchicine is a microtubule-depolymerizing agent that has long been used to induce chromosome individualization in cells arrested at metaphase and also in the induction of polyploid
Giuseppe La Regina et al.
Journal of medicinal chemistry, 54(24), 8394-8406 (2011-11-03)
New arylthioindoles (ATIs) were obtained by replacing the 2-alkoxycarbonyl group with a bioisosteric 5-membered heterocycle nucleus. The new ATIs 5, 8, and 10 inhibited tubulin polymerization, reduced cell growth of a panel of human transformed cell lines, and showed higher
Takeki Uehara et al.
Molecular nutrition & food research, 54(2), 218-227 (2009-12-31)
Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to
[Organ damage in collagen vascular diseases: toward the understanding of the complicated conditions (discussion)].
Seiji Minota et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(10), 2653-2666 (2014-01-10)
Marek T Konieczny et al.
European journal of medicinal chemistry, 89, 733-742 (2014-12-03)
Synthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site.
Ruili Huang et al.
Journal of medicinal chemistry, 49(6), 1964-1979 (2006-03-17)
This paper examines two biological models of anticancer activity, cytotoxicity and hollow fiber (HF) activity, for chemotherapeutic agents evaluated as part of the National Cancer Institute's (NCI's) drug screening effort. Our analysis proposes strategies to globally assess compounds tested in
J Fediuk et al.
Pulmonary pharmacology & therapeutics, 30, 1-10 (2014-10-15)
Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by sustained vasospasm and an increased thromboxane:prostacyclin ratio. Thromboxane (TP) receptors signal via Gαq to mobilize IP3 and Ca(2+), causing pulmonary arterial constriction. We have previously reported increased TP internalization in
Bing-Hua Su et al.
Oncotarget, 6(35), 38308-38326 (2015-10-31)
Conditionally replicating adenoviruses (CRAds), or oncolytic adenoviruses, such as E1B55K-deleted adenovirus, are attractive anticancer agents. However, the therapeutic efficacy of E1B55K-deleted adenovirus for refractory solid tumors has been limited. Environmental stress conditions may induce nuclear accumulation of YB-1, which occurs
Mosaad A Abdel-Wahhab et al.
Toxicon : official journal of the International Society on Toxinology, 181, 57-68 (2020-05-01)
This study aimed to identify the bioactive compounds of the ethyl acetate extract of Aspergillus niger SH2-EGY using GC-MS and to evaluate their protective role against aflatoxin B1 (AFB1)-induced oxidative stress, genotoxicity and cytotoxicity in rats. Six groups of male
Massimo Imazio
Giornale italiano di cardiologia (2006), 13(10), 665-672 (2012-10-02)
Colchicine has been recently demonstrated to be efficacious and safe for the prevention of several postoperative complications including the postpericardiotomy syndrome (PPS), postoperative pericardial and pleural effusions, and postoperative atrial fibrillation according to the results of the COPPS trial. The
Dong-Jo Chang et al.
Bioorganic & medicinal chemistry letters, 19(15), 4416-4420 (2009-06-09)
Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well
Hiroyuki Imai et al.
PloS one, 10(6), e0130585-e0130585 (2015-06-20)
Polyploid amphibians and fishes occur naturally in nature, while polyploid mammals do not. For example, tetraploid mouse embryos normally develop into blastocysts, but exhibit abnormalities and die soon after implantation. Thus, polyploidization is thought to be harmful during early mammalian
Sara Hoet et al.
Journal of natural products, 70(8), 1360-1363 (2007-07-20)
Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol
Santanu Paul et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 67, 153152-153152 (2019-12-31)
Lung cancer is the leading cause of cancer-related deaths worldwide. Several targets have been identified for lung cancer therapy, amongst which 'Microtubule' and its dynamics are the most widely studied and used in therapy. Tubulin-microtubule polymer dynamics are highly sought
Mikiko Tsukimoto et al.
Biopharmaceutics & drug disposition, 36(1), 15-33 (2014-09-30)
Aliskiren is a substrate for P-glycoprotein (P-gp) and is metabolized via cytochrome P450 3A4 (CYP3A4). The aim of the present study was to assess whether P-gp influenced the pharmacokinetics of aliskiren and also if drug-drug interactions (DDIs) mediated through P-gp
Joost Frenkel et al.
Nederlands tijdschrift voor geneeskunde, 157(18), A5784-A5784 (2013-05-03)
Familial Mediterranean fever (FMF) is common among Turkish and Moroccan migrants. We describe three patients with FMF. A 3-year-old girl with recurrent fever and abdominal pain who was diagnosed early with FMF and treated effectively with colchicine. An adolescent girl
Isabel Lozoya-Agullo et al.
Journal of pharmaceutical sciences, 104(9), 3136-3145 (2015-04-22)
Our aim is to develop and to validate the in situ closed loop perfusion method in rat colon and to compare with small intestine and Caco-2 cell models. Correlations with human oral fraction absorbed (Fa) and human colon fraction absorbed
Anne Zuse et al.
Journal of medicinal chemistry, 50(24), 6059-6066 (2007-11-02)
Benzenesulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone were prepared and found to inhibit microtubule formation by an in vitro tubulin polymerization assay. Several analogues showed potent cytotoxic activity in an assay based on K562 leukemia cells with IC50 values of <100
Li-Ting Liao et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)
Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of
Ahmed Waraky et al.
Oncotarget, 5(18), 8379-8392 (2014-10-01)
Picropodophyllin (PPP) is an anticancer drug undergoing clinical development in NSCLC. PPP has been shown to suppress IGF-1R signaling and to induce a G2/M cell cycle phase arrest but the exact mechanisms remain to be elucidated. The present study identified
A rare cause of diffuse abdominal pain and fullness in a 57-year-old man.
Pao-Ying Lin et al.
Gastroenterology, 147(2), e5-e6 (2014-06-29)
Demetrio Raffa et al.
European journal of medicinal chemistry, 46(7), 2786-2796 (2011-05-03)
Several new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides 12a-s and 17t-v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl)acrylic acid chlorides 11c-k and 11t-v with the appropriate anthranilamide derivatives 10a-c or the 5-iodoanthranilic acid 13. Some of the synthesized compounds were evaluated for their in
Lucía Del Priore et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 23(2), 199-210 (2015-01-19)
Meiotic recombination in the Japanese quail was directly studied by immunolocalization of mutL homolog 1 (MLH1), a mismatch repair protein of mature recombination nodules. In total, 15,862 crossovers were scored along the autosomal synaptonemal complexes in 308 meiotic nuclei from
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