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Showing 1-19 of 19 results for "C6243" within Papers
SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes
Burgert T, et.al.
Molecular and Cellular Biology, 33(21), 4308-4320 (2013)
Dissociation of Ionizing Groups in the Binding Cleft Inversely Controls
the Endo- and Exopeptidase Activities of Cathepsin B
Polgar L and Csoma C
The Journal of Biological Chemistry, 292, 1444&14453- 1444&14453 (1987)
Blockade of cathepsin B expression in human glioblastoma cells is
associated with suppression of angiogenesis
Yanamandra N
Oncogene, 23, 2224?2230-2224?2230 (2004)
Patricia García-Sanz et al.
Movement disorders : official journal of the Movement Disorder Society, 32(10), 1409-1422 (2017-08-06)
Heterozygous mutations in the GBA1 gene, which encodes the lysosomal enzyme β-glucocerebrosidase-1, increase the risk of developing Parkinson's disease, although the underlying mechanisms remain unclear. The aim of this study was to explore the impact of the N370S-GBA1 mutation on
Frequency of CFTR, SPINK1, and Cathepsin B Gene Mutation in North Indian Population: Connections between Genetics and Clinical Data
Singh S
TheScientificWorldJournal, 1-6 (2014)
Le Yu et al.
Oncotarget, 7(12), 14693-14707 (2016-02-26)
Obatoclax, a pan-inhibitor of anti-apoptotic Bcl-2 proteins, exhibits cytotoxic effect on cancer cells through both apoptosis-dependent and -independent pathways. Here we show that obatoclax caused cytotoxicity in both cisplatin-sensitive and -resistant esophageal cancer cells. Although obatoclax showed differential apoptogenic effects
Salik Hussain et al.
Particle and fibre toxicology, 7, 10-10 (2010-04-20)
Increasing environmental and occupational exposures to nanoparticles (NPs) warrant deeper insight into the toxicological mechanisms induced by these materials. The present study was designed to characterize the cell death induced by carbon black (CB) and titanium dioxide (TiO2) NPs in
Yisel M Cantres-Rosario et al.
Scientific reports, 9(1), 8006-8006 (2019-05-31)
HIV-associated neurocognitive disorders prevail in 20-50 percent of infected individuals. Macrophages transmigrate through the blood brain barrier during HIV-1 infection, triggering neuronal dysfunction. HIV-infected macrophages secrete cathepsin B (CATB), and serum amyloid p component (SAPC), inducing neuronal apoptosis by an
Protease signalling in cell death: caspases versus cysteine cathepsins
Turk B and Stoka V
Febs Letters, 581, 2761?2767-2761?2767 (2007)
Juan Carlos Gómora-García et al.
Cells, 12(3) (2023-02-12)
Mitochondrial activity and quality control are essential for neuronal homeostasis as neurons rely on glucose oxidative metabolism. The ketone body, D-β-hydroxybutyrate (D-BHB), is metabolized to acetyl-CoA in brain mitochondria and used as an energy fuel alternative to glucose. We have
Enzymatically active lysosomal proteases are associated with
amyloid deposits in Alzheimer brain
Cataldo AM and Nixon RA
Proceedings of the National Academy of Sciences of the USA, 87, 3861-3865 (1990)
Zhe Li et al.
Acta pharmacologica Sinica, 42(4), 624-632 (2020-07-25)
The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemisinin, displays broad antitumor activity and
Cysteine Cathepsins and the Cutting Edge of
Cancer Invasion
Gocheva V and Joyce JA
Cell Cycle, 6:1, 60-64 (2007)
Localization and Activity of Various Lysosomal Proteases in
Leishmania amazonensis-Infected Macrophages
Prina E
Infection and Immunity, 58, 1730-1737 (1990)
Xuesong Chen et al.
Frontiers in aging neuroscience, 8, 129-129 (2016-07-05)
Deficits in skeletal muscles contribute not only to the functional decline in people living with Alzheimer's disease (AD), but also to AD pathogenesis. We have shown that endolysosome dysfunction plays an important role in the development of AD pathological features
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of
Tilman Burgert et al.
Molecular and cellular biology, 33(21), 4308-4320 (2013-09-05)
Sorting-related receptor with A-type repeats (SORLA) is a sorting receptor for the amyloid precursor protein (APP) that prevents breakdown of APP into Aβ peptides, a hallmark of Alzheimer's disease (AD). Several cytosolic adaptors have been shown to interact with the
Nucleotide, Cytogenetic and Expression Impact of the Human Chromosome 8p23.1 Inversion Polymorphism
Bosch N
PLoS ONE, 4, 1-9 (2009)
Iris Munhoz Costa et al.
International journal of molecular sciences, 24(13) (2023-07-14)
L-Asparaginase (ASNase) is a biopharmaceutical used as an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Yet, some cases of ALL are naturally resistant to ASNase treatment, which results in poor prognosis. The REH ALL cell line, used
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