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Showing 1-30 of 42 results for "C6680" within Papers
Zhe Liu et al.
Neural regeneration research, 18(12), 2773-2780 (2023-07-14)
Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells. The mammalian optic nerve, an
Shigeki Ohta et al.
Methods in molecular biology (Clifton, N.J.), 989, 193-215 (2013-03-14)
The discovery of human induced pluripotent stem cells (iPSCs) has provided a model system for studying early events during human development. Developmentally melanocytes originate from migratory neural crest cells that emerge from the neural plate during embryogenesis after a complex
Xian Li et al.
PloS one, 6(10), e26029-e26029 (2011-10-22)
Neural crest stem cells (NCSCs) play an important role in the development and represent a valuable cell source for tissue engineering. However, how mechanical factors in vivo regulate NCSC differentiation is not understood. Here NCSCs were derived from induced pluripotent
A robust method to derive functional neural crest cells from human pluripotent stem cells
Kreitzer FR, et al.
American Journal of Stem Cells, 2(2), 119-119 (2013)
Frank Pui-Ling Lai et al.
Gastroenterology, 153(1), 139-153 (2017-03-28)
Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of Hirschsprung disease
Yves Allory et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 54(5), 575-584 (2006-01-13)
The HNK-1 carbohydrate epitope is a 3-sulfo-glucuronyl residue attached to lactosamine structures on glycoproteins, proteoglycans, or glycolipids mostly expressed in the nervous system. Here, using monoclonal antibodies against the sulfated HNK-1 carbohydrate epitope, we first examined its distribution in developing
Gabsang Lee et al.
Nature protocols, 5(4), 688-701 (2010-04-03)
Human pluripotent stem cell (hPSC)-derived neural crest (NC) cells present a valuable tool for modeling aspects of human NC development, including cell fate specification, multipotency and cell migration. hPSC-derived NC cells are also suitable for modeling human disease and as
Young Hyun Che et al.
International journal of stem cells, 16(3), 269-280 (2023-06-30)
The colonic epithelial layer is a complex structure consisting of multiple cell types that regulate various aspects of colonic physiology, yet the mechanisms underlying epithelial cell differentiation during development remain unclear. Organoids have emerged as a promising model for investigating
A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis
Dubaissi E, et al.
Development, 141(7), 1514-1525 (2014)
Achim Werner et al.
Nature, 525(7570), 523-527 (2015-09-25)
Metazoan development depends on the accurate execution of differentiation programs that allow pluripotent stem cells to adopt specific fates. Differentiation requires changes to chromatin architecture and transcriptional networks, yet whether other regulatory events support cell-fate determination is less well understood.
Joseph D Trimarco et al.
Nature communications, 13(1), 6456-6456 (2022-10-31)
Communicable respiratory viral infections pose both epidemic and pandemic threats and broad-spectrum antiviral strategies could improve preparedness for these events. To discover host antiviral restriction factors that may act as suitable targets for the development of host-directed antiviral therapies, we
Laura Menendez et al.
Nature protocols, 8(1), 203-212 (2013-01-05)
Multipotent neural crest stem cells (NCSCs) have the potential to generate a wide range of cell types including melanocytes; peripheral neurons; and smooth muscle, bone, cartilage and fat cells. This protocol describes in detail how to perform a highly efficient
Richard W Naylor et al.
PloS one, 11(10), e0165464-e0165464 (2016-10-30)
Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based therapies may offer an alternative approach given that the
Michelle Dookwah et al.
Human molecular genetics, 32(24), 3323-3341 (2023-09-07)
GM3 Synthase Deficiency (GM3SD) is a neurodevelopmental disorder resulting from pathogenic variants in the ST3GAL5 gene, which encodes GM3 synthase, a glycosphingolipid (GSL)-specific sialyltransferase. This enzyme adds a sialic acid to the terminal galactose of lactosylceramide (LacCer) to produce the
W Tongtako et al.
Scientific reports, 7(1), 13915-13915 (2017-10-27)
Dogs can be used as a translational animal model to close the gap between basic discoveries in rodents and clinical trials in humans. The present study compared the species-specific properties of satellite glial cells (SGCs) of canine and murine dorsal
Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis
Hu G and Wang S
Oncotarget, 9(8), 8111-8111 (2018)
Benjamin D Gastfriend et al.
Current protocols, 1(1), e21-e21 (2021-01-24)
Brain pericytes regulate diverse aspects of neurovascular development and function, including blood-brain barrier (BBB) induction and maintenance. Primary brain pericytes have been widely employed in coculture-based in vitro models of the BBB, and a method to generate brain pericytes from
Congshan Sun et al.
JCI insight, 5(11) (2020-04-29)
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. In the present study, when human induced pluripotent stem cells (hiPSCs) were differentiated into myoblasts, the myoblasts derived from DMD patient hiPSCs (DMD hiPSC-derived myoblasts) exhibited an identifiable DMD-relevant phenotype:
Immunohistological analysis of CD1a+ langerhans cells and CD57+ natural killer cells in healthy and diseased human gingival tissue: A comparative study
Stelin S, et al.
Journal of Indian Society of Periodontology, 13(3), 150-150 (2009)
Waseem K Raja et al.
PloS one, 17(12), e0277532-e0277532 (2022-12-02)
There are currently no preventive or disease-modifying therapies for Parkinson's Disease (PD). Failures in clinical trials necessitate a re-evaluation of existing pre-clinical models in order to adopt systems that better recapitulate underlying disease mechanisms and better predict clinical outcomes. In
Minjuan Wang et al.
International journal of molecular sciences, 21(19) (2020-09-30)
Because of the importance of the HNK-1 carbohydrate for preferential motor reinnervation after injury of the femoral nerve in mammals, we screened NIH Clinical Collection 1 and 2 Libraries and a Natural Product library comprising small organic compounds for identification
Martin Kann et al.
Development (Cambridge, England), 142(7), 1254-1266 (2015-03-26)
Development of the metanephric kidney depends on tightly regulated interplay between self-renewal and differentiation of a nephron progenitor cell (NPC) pool. Several key factors required for the survival of NPCs have been identified, including fibroblast growth factor (FGF) signaling and
Atsushi Tomokiyo et al.
Journal of cellular physiology, 232(2), 402-416 (2016-10-31)
Neural crest cells (NCC) hold great promise for tissue engineering, however the inability to easily obtain large numbers of NCC is a major factor limiting their use in studies of regenerative medicine. Induced pluripotent stem cells (iPSC) are emerging as
M Angeles RabadƔn et al.
Development (Cambridge, England), 143(12), 2194-2205 (2016-04-29)
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a process that is influenced by Wnt/Ī²-catenin signalling. Using two in vivo models, we show that Wnt/Ī²-catenin signalling is transiently inhibited at the time
The role of TRAF4 and B3GAT1 gene expression in the food hypersensitivity and insect venom allergy in mastocytosis
Gorska A, et al.
Archivum Immunologiae et Therapiae Experimentalis, 64(6), 497-503 (2016)
Yifan Zhao et al.
Cell proliferation, 57(6), e13598-e13598 (2024-01-10)
Ecto-mesenchymal cells of mammalian tooth germ develops from cranial neural crest cells. These cells are recognised as a promising source for tooth development and regeneration. Despite the high heterogeneity of the neural crest, the cellular landscape of in vitro cultured
Nicole Steffensen et al.
Journal of tissue engineering and regenerative medicine, 12(1), e422-e437 (2017-05-17)
Schwann cells are promising candidates for transplantation strategies in the central nervous system by promoting axonal regeneration. The dog represents a translational model for human spinal cord injury (SCI) for studies with new repair strategies after intervertebral disk herniation (IVDH).
Clark A Lindgren et al.
The Journal of physiology, 591(19), 4749-4764 (2013-07-03)
Previous work has demonstrated that activation of muscarinic acetylcholine receptors at the lizard neuromuscular junction (NMJ) induces a biphasic modulation of evoked neurotransmitter release: an initial depression followed by a delayed enhancement. The depression is mediated by the release of
Malkiel A Cohen et al.
Cell stem cell, 26(4), 579-592 (2020-03-07)
Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here, we establish a platform that allows the study of human NBs in mouse-human NC chimeras. Chimeric mice were produced by injecting human NC
Ching-Wen Huang et al.
Scientific reports, 7(1), 17401-17401 (2017-12-14)
In regenerative medicine applications, the differentiation stage of implanted stem cells must be optimized to control cell fate and enhance therapeutic efficacy. We investigated the therapeutic potential of human induced pluripotent stem cell (iPSC)-derived cells at two differentiation stages on
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