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Showing 1-6 of 6 results for "C7182" within Papers
Gaston Bonenfant et al.
Journal of virology, 93(12) (2019-04-05)
Flaviviruses limit the cell stress response by preventing the formation of stress granules (SGs) and modulate viral gene expression by subverting different proteins involved in the stress granule pathway. In this study, we investigated the formation of stress granules during
Chushu Li et al.
Oncogene, 40(6), 1128-1146 (2020-12-17)
Cancer cell expression of PD-L1 leads to T cells exhaustion by transducing co-inhibitory signal, and further understanding the regulation of PD-L1 in cancer cells may provide additional therapeutic strategies. Here by drug repurposing screen, we identified amlodipine as a potent
N Joly-Tonetti et al.
The British journal of dermatology, 179(5), 1115-1126 (2018-06-30)
Melanin is synthesized by melanocytes in the basal layer of the epidermis. When transferred to surrounding keratinocytes melanin is the key ultraviolet radiation-protective biopolymer responsible for skin pigmentation. Most melanin is observable in the proliferative basal layer of the epidermis
Beatrice Paola Festa et al.
Nature communications, 9(1), 161-161 (2018-01-13)
The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells. Lysosomal storage diseases such as nephropathic cystinosis cause a major dysfunction of epithelial cells lining the kidney tubule, resulting in massive losses of vital solutes in the urine. The
Dakota J Brock et al.
Cell chemical biology, 27(10), 1296-1307 (2020-08-14)
Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes the improvement of delivery agents. Here
Gemma Palazzolo et al.
Translational oncology, 13(4), 100760-100760 (2020-04-05)
Although screening has reduced mortality rates for colorectal cancer (CRC), about 20% of patients still carry metastases at diagnosis. Postsurgery chemotherapy is toxic and induces drug resistance. Promising alternative strategies rely on repurposing drugs such as aspirin (ASA) and metformin
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