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Showing 1-30 of 100 results for "C7207" within Papers
Bryan T MacDonald et al.
Developmental cell, 17(1), 9-26 (2009-07-22)
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their
Yarong Guo et al.
Translational oncology, 14(6), 101059-101059 (2021-03-19)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Lenvatinib oral chemotherapy is approved as a first-line treatment of patients with unresectable HCC. The efficacy and therapeutic duration of lenvatinib are limited by drug resistance, and the
Andrea Mafficini et al.
Genes, 12(4) (2021-04-04)
This case report describes the history of a 41 year-old woman with a solid pseudopapillary neoplasm (SPN) of the pancreas and a metachronous abdominal desmoid tumor (DT) that occurred two years after the SPN surgical resection. At next-generation sequencing of
Wen-Hui Lien et al.
Nature cell biology, 16(2), 179-190 (2014-01-28)
Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β-catenin-TCF3/4-TLE circuitry, and genetically dissect their biological roles within the native HFSC niche. We show that during HFSC quiescence
Marion Baraban et al.
Developmental cell, 58(5), 361-375 (2023-02-26)
Despite their barrier function, epithelia can locally lose their integrity to create physiological openings during morphogenesis. The mechanisms driving the formation of these epithelial breaks are only starting to be investigated. Here, we study the formation of the zebrafish nostril
Lindsey Mork et al.
Evolution & development, 15(2), 96-106 (2013-03-01)
In reptiles such as the red-eared slider turtle Trachemys scripta, development of an ovary from the bipotential gonad requires a coordinated expansion of the cortical domain and regression of the medulla. While estrogen, which is necessary and sufficient for ovarian
Honami Yonezawa et al.
iScience, 25(3), 103912-103912 (2022-05-10)
Ivermectin (IVM), an avermectin-derivative anthelmintic, specifically binds to glutamate-gated chloride ion channels (GluCls), causing paralysis in invertebrates. IVM also exhibits other biological activities such as Wnt/β-catenin pathway inhibition in vertebrates that do not possess GluCls. This study showed that affinity
Joo-Leng Low et al.
iScience, 24(6), 102544-102544 (2021-06-19)
Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we developed and optimized a computational model of β-cat using
Martina Radić et al.
International journal of molecular sciences, 23(17) (2022-09-10)
Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic A375M, with acquired resistance to
Xiaofeng Han et al.
Stem cells and development, 31(5-6), 111-118 (2022-01-20)
Extrinsic injury can evoke intrinsic stimulation and subsequently initiate the physiological repair process. This study aims to investigate whether clinically acceptable micro-injury could be used to create local stimuli to induce hair regeneration and vitiligo repigmentation. A novel device was
Mark S Filla et al.
Cells, 12(3) (2023-02-12)
Although elevated TGFβ2 levels appear to be a causative factor in glaucoma pathogenesis, little is known about how TGFβ2 expression is regulated in the trabecular meshwork (TM). Here, we investigated if activation of the cytokine regulator NFATc1 controlled transcription of
Pleasantine Mill et al.
PLoS genetics, 5(11), e1000748-e1000748 (2009-12-04)
Palmitoylation is a key post-translational modification mediated by a family of DHHC-containing palmitoyl acyl-transferases (PATs). Unlike other lipid modifications, palmitoylation is reversible and thus often regulates dynamic protein interactions. We find that the mouse hair loss mutant, depilated, (dep) is
Jin-Xiu Pan et al.
Bone research, 6, 18-18 (2018-06-07)
YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence
The WNT signaling pathway and its role in human solid tumors
Thorstensen L and Lothe RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 7(2), 146-161 (2003)
Keren Weiser et al.
PloS one, 8(10), e77865-e77865 (2013-10-17)
The Wnt signaling pathway is implicated in major physiologic cellular functions, such as proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Proliferation and migration are important responses of T-cells, which are major cellular targets of HIV
Xiaohong Yin et al.
Journal of cellular biochemistry, 120(6), 9724-9736 (2018-12-26)
Adamantinomatous craniopharyngiomas (adaCP) accounts for 5.6% to 15% of intracranial tumors. High expression of chemokine (C-X-C motif) ligand 12 (CXCL12, also known as stromal cell-derived factor 1 [SDF1]) and its receptor CXC receptor type 4 (CXCR4) are widespread in various
Maryam Yousefi et al.
The Journal of cell biology, 215(3), 401-413 (2016-11-02)
Regeneration of the intestinal epithelium is driven by multiple intestinal stem cell (ISC) types, including an active, radiosensitive Wnt
Shu-Yu Wu et al.
PLoS biology, 10(10), e1001403-e1001403 (2012-10-12)
Embryonic axis formation in vertebrates is initiated by the establishment of the dorsal Nieuwkoop blastula organizer, marked by the nuclear accumulation of maternal β-catenin, a transcriptional effector of canonical Wnt signaling. Known regulators of axis specification include the canonical Wnt
Naoyuki Nishiya et al.
Cancer science, 112(5), 1963-1974 (2021-02-06)
The emergence of acquired resistance is a major concern associated with molecularly targeted kinase inhibitors. The C797S mutation in the epidermal growth factor receptor (EGFR) confers resistance to osimertinib, a third-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI). We report that the derivatization
Beiyun Zhou et al.
The Journal of biological chemistry, 287(10), 7026-7038 (2012-01-14)
Interactions between transforming growth factor-β (TGF-β) and Wnt are crucial to many biological processes, although specific targets, rationale for divergent outcomes (differentiation versus block of epithelial proliferation versus epithelial-mesenchymal transition (EMT)) and precise mechanisms in many cases remain unknown. We
Benjamin Tajer et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(15) (2021-04-09)
Heterodimeric TGF-β ligands outperform homodimers in a variety of developmental, cell culture, and therapeutic contexts; however, the mechanisms underlying this increased potency remain uncharacterized. Here, we use dorsal-ventral axial patterning of the zebrafish embryo to interrogate the BMP2/7 heterodimer signaling
Kun-Yang Lin et al.
The Journal of biological chemistry, 290(50), 29808-29819 (2015-10-18)
Wnt/β-catenin signaling controls various cell fates in metazoan development, and its dysregulation is often associated with cancer formation. However, regulations of this signaling pathway are not completely understood. Here, we report that Lzap, a tumor suppressor, controls nuclear translocation of
Hirofumi Yasumuro et al.
Biomedicines, 5(2) (2017-05-26)
The newt is an amazing four-limbed vertebrate that can regenerate various body parts including the retina. In this animal, when the neural retina (NR) is removed from the eye by surgery (retinectomy), both the NR and the retinal pigment epithelium
Antonio Herrera et al.
Nature communications, 5, 4168-4168 (2014-06-20)
β-Catenin mediates the canonical Wnt pathway by stimulating Tcf-dependent transcription and also associates to N-cadherin at the apical complex (AC) of neuroblasts. Here, we show that while β-catenin activity is required to form the AC and to maintain the cell
Timothy Fulton et al.
Current biology : CB, 30(15), 2984-2994 (2020-06-20)
A fundamental question in developmental biology is how the early embryo establishes the spatial coordinate system that is later important for the organization of the embryonic body plan. Although we know a lot about the signaling and gene-regulatory networks required
Nathan C Bird et al.
Methods in molecular biology (Clifton, N.J.), 798, 153-169 (2011-12-02)
During myogenesis, cells gradually transition from mesodermal precursors to myoblasts, myocytes, and then to muscle fibers. The molecular characterization of this process requires the ability to identify each of these cell types and the factors that regulate the transitions between
Yiqi Huang et al.
Nature communications, 15(1), 6778-6778 (2024-08-09)
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation despite its high sequence similarity to VACV.
Robyn S Allen et al.
eLife, 9 (2020-09-09)
Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic disorder characterized by altered skeletal development and extraskeletal ossification. All cases of FOP are caused by activating mutations in the type I BMP/TGFβ cell surface receptor ACVR1, which over-activates signaling through
Joke Tommelein et al.
Oncotarget, 7(46), 75603-75615 (2016-10-01)
In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic inoculations of human colorectal cancer cells into the caecal wall
Claudio Doglioni et al.
The American journal of pathology, 163(6), 2277-2287 (2003-11-25)
To determine the role of beta-catenin pathway in human skin carcinogenesis, 135 non-melanoma skin tumors were analyzed for beta-catenin expression and gene mutations. Intense nucleo-cytoplasmic immunoreactivity for C terminus beta-catenin antibodies was observed in all pilomatricomas and in single cases
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