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Showing 1-30 of 43 results for "C7930" within Papers
Margaret H Chang et al.
Cell reports, 37(4), 109902-109902 (2021-10-28)
Rheumatoid arthritis is a systemic autoimmune disease, but disease flares typically affect only a subset of joints, distributed in a distinctive pattern for each patient. Pursuing this intriguing pattern, we show that arthritis recurrence is mediated by long-lived synovial resident
Stephanie Arndt et al.
Gut, 64(6), 973-981 (2014-07-12)
Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this
Yan Wu et al.
Journal of neuroscience research, 95(8), 1666-1676 (2016-11-30)
This study aims to explore the temporal changes of cytotoxic CD8+ CD28+ and regulatory CD8+ CD28- T-cell subsets in the lesion microenvironment after spinal cord injury (SCI) in rats, by combination of immunohistochemistry (IHC) and flow cytometry (FCM). In the
Liming Tao et al.
Cell reports methods, 1(3), None-None (2021-08-04)
Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals. In contrast, human cell lineage remains
Judith Sommer et al.
Cells, 9(1) (2020-01-23)
Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-specific manner. In this study, we aimed
Christoph Dorn et al.
Laboratory investigation; a journal of technical methods and pathology, 94(4), 394-408 (2014-02-05)
Overnutrition is the major cause of nonalcoholic fatty liver disease (NAFLD) and its advanced form nonalcoholic steatohepatitis (NASH). We aimed to develop and characterize a murine model, which resembles both the pathology and nutritional situation, of NASH patients in Western
Quantification and Three-Dimensional Imaging of the Insulitis-Induced Destruction of beta-Cells in Murine Type 1 Diabetes
Alanentalo T, et al.
Diabetes, 59(7), 1756-1764 (2010)
Emma L House et al.
Toxics, 9(12) (2021-12-24)
Diacetyl (DA) is a highly reactive alpha diketone associated with flavoring-related lung disease. In rodents, acute DA vapor exposure can initiate an airway-centric, inflammatory response. However, this immune response has yet to be fully characterized in the context of flavoring-related
Stephanie Arndt et al.
The Journal of investigative dermatology, 139(9), 1914-1924 (2019-03-18)
BMP6 is known to be crucial for regulating embryonic skin development. This study assessed the role of BMP6 in dermal fibrosis. We detected that BMP6 is significantly increased in skin-derived fibroblasts of patients with localized scleroderma. Moreover, it was shown
Rajesh Katare et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(2), 408-418 (2013-11-10)
CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC
Spontaneous Mammary Tumors Differ Widely in Their Inherent Sensitivity to Adoptively Transferred T Cells
Wall EM, et al.
Cancer research, 67(13), 6442-6450 (2007)
The T cell receptor/CD3 complex: a dynamic protein ensemble
Clevers H, et al.
Annual Review of Immunology, 6(1), 629-662 (1988)
Carla Rossana Scalia et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65(1), 5-20 (2016-11-01)
Antigen masking in routinely processed tissue is a poorly understood process caused by multiple factors. We sought to dissect the effect on antigenicity of each step of processing by using frozen sections as proxies of the whole tissue. An equivalent
Brent A Hanks et al.
The Journal of clinical investigation, 123(9), 3925-3940 (2013-08-09)
Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that local tumor-associated DC populations exhibit tolerogenic features by promoting Treg development; however, the mechanisms by
Abdo Mahli et al.
Cells, 8(4) (2019-04-20)
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether
Zeeshan H Syedain et al.
Tissue engineering. Part A, 20(11-12), 1726-1734 (2014-01-15)
The performance of completely biological, decellularized engineered allografts in a sheep model was evaluated to establish clinical potential of these unique arterial allografts. The 4-mm-diameter, 2-3-cm-long grafts were fabricated from fibrin gel remodeled into an aligned tissue tube in vitro
Anya Medina et al.
Diabetologia, 61(4), 896-905 (2017-12-07)
Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. We used 40-day-old BioBreeding (BB)
Vanna Denti et al.
Metabolites, 11(9) (2021-09-27)
Predicting the prognosis of colorectal cancer (CRC) patients remains challenging and a characterisation of the tumour immune environment represents one of the most crucial avenues when attempting to do so. For this reason, molecular approaches which are capable of classifying
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
Hueso, et al.
Frontiers in Endocrinology, 14, 1154158-1154158 (2023)
Anna Kathrin Assmann et al.
Journal of cardiovascular pharmacology, 79(1), e103-e115 (2021-10-17)
Aortic valve replacement for severe stenosis is a standard procedure in cardiovascular medicine. However, the use of biological prostheses has limitations especially in young patients because of calcifying degeneration, resulting in implant failure. Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Most Jacobsen syndrome deletion breakpoints occur distal to FRA11B.
Michaelis RC, et al.
American Journal of Medical Genetics (1998)
Vishal Singh et al.
Cell, 175(3), 679-694 (2018-10-20)
Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet
Nadir Kadri et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3138-3149 (2012-03-01)
Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which
M Mazzoni et al.
Poultry science, 94(1), 123-130 (2015-01-13)
A trial was conducted to evaluate the influence of myodegeneration of pectoralis major muscle on quality traits and chemical composition of breast meat of heavy-size male broilers. For this purpose, a total of 72 pectoralis major muscles were randomly collected
Chuanhai Cao et al.
Neurobiology of disease, 34(1), 63-70 (2009-01-27)
We have found that a small number of purified Th2-biased Abeta-specific T cells are sufficient to provide profound cognitive and pathological benefits in an APP+PS1 mouse model for Alzheimer's disease. Six weeks after receiving T cell infusions, cognitively-impaired mice performed
Janna Schneppenheim et al.
The Journal of experimental medicine, 210(1), 41-58 (2012-12-26)
Regulated intramembrane proteolysis is a central cellular process involved in signal transduction and membrane protein turnover. The presenilin homologue signal-peptide-peptidase-like 2a (SPPL2a) has been implicated in the cleavage of type 2 transmembrane proteins. We show that the invariant chain (li
Barbara Spix et al.
Nature communications, 13(1), 318-318 (2022-01-16)
Lung emphysema and chronic bronchitis are the two most common causes of chronic obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is predominantly secreted from alveolar macrophages, is known to mediate the development of lung injury and emphysema. Here, we
Yutaro Mori et al.
Cell metabolism, 33(5), 1042-1061 (2021-05-06)
Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease (DKD), and their targeting may be an effective means for prevention. Proximal tubular (PT) expression of kidney injury molecule (KIM)-1, as well as blood and urinary levels, are increased
Carlotta Lambertini et al.
Frontiers in veterinary science, 7, 158-158 (2020-04-17)
Proteinase activated receptor 4 (PAR4) in the gastrointestinal tract is involved in the regulation of inflammation and pain pathways. The aim of the present study was to evaluate the distribution and expression of PAR4 in the jejunum of healthy horses
Jie Jia et al.
EMBO molecular medicine, 10(5) (2018-04-21)
The development of chronic obstructive pulmonary disease (COPD) pathogenesis remains unclear, but emerging evidence supports a crucial role for inducible bronchus-associated lymphoid tissue (iBALT) in disease progression. Mechanisms underlying iBALT generation, particularly during chronic CS exposure, remain to be defined.
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