Search Within
C8273
Applied Filters:
Keyword:'C8273'
Showing 1-30 of 461 results for "C8273" within Papers
Saima I Machlovi et al.
Neurobiology of disease, 164, 105615-105615 (2022-01-16)
Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of
Giovanna Leoni et al.
The Journal of clinical investigation, 125(3), 1215-1227 (2015-02-11)
Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understanding of the epithelial restitution process has
Hager Mohamed et al.
PloS one, 16(3), e0247125-e0247125 (2021-03-02)
Effective control of infection by human immunodeficiency virus type 1 (HIV-1), the causative agent of the acquired immunodeficiency syndrome (AIDS), requires continuous and life-long use of anti-retroviral therapy (ART) by people living with HIV-1 (PLWH). In the absence of ART
Sarah Fox et al.
Journal of inflammation (London, England), 12, 51-51 (2015-09-12)
Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, enhanced by the presence of various bridging molecules and opsonins which
M F Veale et al.
Vox sanguinis, 106(3), 219-226 (2013-10-15)
Refrigerated storage of red blood cells (RBCs) induces numerous changes that may target the cells for erythrophagocytosis following transfusion. The influence of storage upon the phagocytosis of unseparated and fractionated young and old stored RBCs was investigated using two in
Luz P Blanco et al.
Arthritis & rheumatology (Hoboken, N.J.), 73(12), 2282-2292 (2021-05-14)
Neutrophil extracellular traps (NETs) are extracellular lattices composed of nucleic material bound to neutrophil granule proteins. NETs may play pathogenic roles in the development and severity of autoimmune diseases such as systemic lupus erythematosus (SLE), at least in part, through
Aaron R Navratil et al.
Infection and immunity, 82(8), 3299-3311 (2014-05-29)
Francisella tularensis induces the synthesis of prostaglandin E(2) (PGE(2)) by infected macrophages to alter host immune responses, thus providing a survival advantage to the bacterium. We previously demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2))
Cecilia Casaravilla et al.
Infection and immunity, 82(8), 3164-3176 (2014-05-21)
The larval stage of the cestode parasite Echinococcus granulosus causes hydatid disease in humans and livestock. This infection is characterized by the growth in internal organ parenchymae of fluid-filled structures (hydatids) that elicit surprisingly little inflammation in spite of their
Fushan Shi et al.
Journal of neuroimmunology, 260(1-2), 121-125 (2013-05-18)
Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined
Matthew Day et al.
Nature communications, 15(1), 1797-1797 (2024-02-28)
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two
Robert A Gutierrez et al.
Biomaterials, 270, 120684-120684 (2021-02-04)
Mechanical forces are an essential element to early tissue formation. However, few techniques exist that can quantify the mechanical microenvironment present within cell-dense neotissues and organoid structures. Here is a versatile approach to measure microscale, cellular forces during mesenchymal condensation
Giuliano Scarcelli et al.
Nature methods, 12(12), 1132-1134 (2015-10-06)
Current measurements of the biomechanical properties of cells require physical contact with cells or lack subcellular resolution. Here we developed a label-free microscopy technique based on Brillouin light scattering that is capable of measuring an intracellular longitudinal modulus with optical
Eugene Won Park et al.
Histochemistry and cell biology, 155(1), 9-18 (2020-11-03)
Rab35 is a small G protein involved in various cellular events including clathrin-dependent endocytosis, phagocytosis, and autophagy. DENND1B, a DENN family member, acts as a guanine nucleotide exchange factor (GEF) for Rab35 to convert it to the GTP-bound active form
AndrƩ-Patrick Arrigo
Methods in molecular biology (Clifton, N.J.), 787, 105-119 (2011-09-08)
Human HspB1 (also denoted Hsp27) is a well-known member, together with alphaB-crystallin, of the small heat-shock (or stress) proteins (sHsps) (20-40 kDa). In this chapter, I describe procedures for testing the oligomeric and phosphorylation patterns of HspB1 as well as
Yan Li et al.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 24(3), 231-239 (2014-07-24)
Ovarian cancer is characterized by a rapid intraperitoneal spread combination with ascites accumulation. However, the exact mechanisms for ovarian cancer intraperitoneal dissemination remain unknown. Visfatin has recently been established as a novel adipokine and its serum level is increased in
Ćzen Sercan Alp et al.
European journal of immunology, 45(4), 975-987 (2015-02-03)
It is believed that memory CD8(+) TĀ cells are maintained in secondary lymphoid tissues, peripheral tissues, and BM by homeostatic proliferation. Their survival has been shown to be dependent on IL-7, but it is unclear where they acquire it. Here we
Yi-Wei Huang et al.
Journal of cellular physiology, 230(9), 2086-2097 (2015-02-03)
Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role of store-operated Ca(2+) entry, which is the major form of extracellular Ca(2+)
Marco Antonio EscƔrcega-Tame et al.
PloS one, 10(12), e0144078-e0144078 (2015-12-03)
Dystroglycan has recently been characterised in blood tissue cells, as part of the dystrophin glycoprotein complex involved in the differentiation process of neutrophils. In the present study we have investigated the role of dystroglycan in the human promyelocytic leukemic cell
Karen W Cheng et al.
Molecular biology of the cell, 31(18), 2021-2034 (2020-06-25)
The shapes of many eukaryotic cells depends on the actin cytoskeleton, and changes in actin assembly dynamics underlie many changes in cell shape. Ena/VASP-family actin polymerases, for example, modulate cell shape by accelerating actin filament assembly locally and slowing filament
Nils Schallner et al.
The Journal of clinical investigation, 125(7), 2609-2625 (2015-05-27)
Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated erythrocytes that surround the brain contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ dysfunction. Free
Esra Roan et al.
Biophysical journal, 109(10), 2051-2057 (2015-11-21)
Epithelial cell migration during wound repair involves a complex interplay of intracellular processes that enable motility while preserving contact among the cells. Recent evidence suggests that fluctuations of the intracellular biophysical state of cells generate traction forces at the basal
In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells.
Huber, et al.
Nature Communications, 14, 2143-2143 (2023)
Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa.
Martinez, et al.
International Journal of Biological Sciences, 19, 2234-2255 (2023)
Laure BĆ©ven et al.
PloS one, 7(10), e48606-e48606 (2012-11-03)
Spiroplasma citri is a plant pathogenic mollicute transmitted by the leafhopper vector Circulifer haematoceps. Successful transmission requires the spiroplasmas to cross the intestinal epithelium and salivary gland barriers through endocytosis mediated by receptor-ligand interactions. To characterize these interactions we studied
Yukiko Nakaya et al.
Cells, tissues, organs, 193(1-2), 64-73 (2010-11-06)
Regulated disruption of the basement membrane (BM) is a critical step in many epithelial-mesenchymal transition (EMT) processes. Molecular mechanisms controlling the interaction between the BM and the basal membrane of epithelial cells and its subsequent disruption during EMT are poorly
Luis E MuƱoz et al.
Immunity, 51(3), 443-450 (2019-08-20)
The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth
Boguslaw S Wojczyk et al.
Transfusion, 54(12), 3186-3197 (2014-07-22)
In mice, refrigerator-stored red blood cells (RBCs) are cleared by extravascular hemolysis and induce cytokine production. To enhance understanding of this phenomenon, we sought to model it in vitro. Ingestion of refrigerator-stored murine RBCs and subsequent cytokine production were studied
Seishiro Hirano et al.
PloS one, 10(11), e0142062-e0142062 (2015-11-07)
The Macrophage Receptor with COllagenous structure (MARCO) protein is a plasma membrane receptor for un-opsonized or environmental particles on phagocytic cells. Here, we show that MARCO was internalized either by ruffling of plasma membrane followed by macropinocytosis or by endocytosis
Larisa Volceanov et al.
mBio, 5(5), e01802-e01814 (2014-10-09)
Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here
Raphaela P Semper et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3566-3576 (2014-08-31)
Infection with the gram-negative bacterium Helicobacter pylori is the most prevalent chronic bacterial infection, affecting ā¼50% of the world's population, and is the main risk factor of gastric cancer. The proinflammatory cytokine IL-1Ī² plays a crucial role in the development
Page 1 of 16