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Showing 1-30 of 40 results for "C9672" within Papers
Samantha Mahabir et al.
The European journal of neuroscience, 47(12), 1457-1473 (2018-05-31)
Fetal alcohol spectrum disorder is one of the leading causes of mental health issues worldwide. Analysis of zebrafish exposed to alcohol during embryonic development confirmed that even low concentrations of alcohol for a short period of time may have lasting
Melissa Carpenter et al.
Methods in molecular biology (Clifton, N.J.), 331, 153-167 (2006-08-03)
Dopaminergic neurons of human origin have many potential research applications such as in vitro studies on biochemical pathways related to neuronal disorders, and potentially direct cell replacement for therapeutic use. Dopaminergic neurons with apparently normal properties can be produced from
The ubiquitous neural cell adhesion molecule (N-CAM)
Weledji EP and Assob JC
Annals of medicine and surgery, 3(3), 77-81 (2014)
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
Chi L et al.
Testing, 8(6), e65448-e65448 (2013)
Elaine L Shay et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 237(7), 1837-1850 (2008-06-24)
Olfactory sensory neuron (OSN) axons follow stereotypic spatio-temporal paths in the establishment of the olfactory pathway. Extracellular matrix (ECM) molecules are expressed early in the developing pathway and are proposed to have a role in its initial establishment. During later
Expression and localization of neural cell adhesion molecule and polysialic acid during chick corneal development
Mao X, et al.
Investigative Ophthalmology & Visual Science, 53(3), 1234-1243 (2012)
Anine Crous et al.
Royal Society open science, 8(9), 210148-210148 (2021-09-17)
Cancer stem cells (CSCs) are considered to contribute to the recurrence of lung cancer due to their stem-like nature and the involvement of genetic markers associated with drug efflux, regeneration and metastases. Photodynamic therapy (PDT) is a cost-effective and non-invasive
Navita N Lopez et al.
Experimental eye research, 197, 108103-108103 (2020-06-12)
The lamina cribrosa is the initial site of glaucomatous injury. Pathological changes to the lamina cribrosa include posterior displacement of the lamina cribrosa, loss of trophic support, and remodeling of the extracellular matrix. Optic nerve head (ONH) astrocytes and lamina
Lijun Chi et al.
PloS one, 8(6), e65448-e65448 (2013-06-14)
The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and growth factor-dependent signal transduction. The requirement for primary cilia during renal epithelial-mesenchymal tissue interactions that give rise to nephrons is undefined. Here, we used Cre-mediated recombination to generate
Karen Perez de Arce et al.
Nature communications, 14(1), 459-459 (2023-01-29)
Multiple trans-synaptic complexes organize synapse development, yet their roles in the mature brain and cooperation remain unclear. We analyzed the postsynaptic adhesion protein LRRTM1 in the prefrontal cortex (PFC), a region relevant to cognition and disorders. LRRTM1 knockout (KO) mice
Jeremy C McIntyre et al.
Journal of neuroscience research, 88(15), 3243-3256 (2010-10-01)
Neurogenesis of projection neurons requires that axons be initiated, extended, and connected. Differences in the expression of axon growth and guidance genes must drive these events, but comprehensively characterizing these differences in a single neuronal type has not been accomplished.
Stepahnie Yazinski et al.
Journal of neuroscience research, 92(1), 64-73 (2013-10-15)
The unique ability of olfactory neurons to regenerate in vitro has allowed their use for the study of olfactory function, regeneration, and neurodegenerative disorders; thus, characterization of their properties is important. This present study attempts to establish the timeline of
Abha S Bais et al.
Scientific reports, 11(1), 22434-22434 (2021-11-19)
The kidney is a complex organ composed of more than 30 terminally differentiated cell types that all are required to perform its numerous homeostatic functions. Defects in kidney development are a significant cause of chronic kidney disease in children, which
Antoine Reginensi et al.
PLoS genetics, 9(3), e1003380-e1003380 (2013-04-05)
Yap is a transcriptional co-activator that regulates cell proliferation and apoptosis downstream of the Hippo kinase pathway. We investigated Yap function during mouse kidney development using a conditional knockout strategy that specifically inactivated Yap within the nephrogenic lineage. We found
J B Bard et al.
Journal of anatomy, 199(Pt 4), 385-392 (2001-11-06)
This paper reports 3-dimensional confocal microscopy observations on how nephrogenic aggregates form from the NCAM- and Pax2-positive caps (4-5 cells deep) of condensed metanephric mesenchyme surrounding the duct tips of the mouse kidney. Aggregates of 6-8 cells are first seen
Sylvia A Hilliard et al.
Developmental biology, 387(1), 1-14 (2014-01-21)
The balance between nephron progenitor cell (NPC) renewal, survival and differentiation ultimately determines nephron endowment and thus susceptibile to chronic kidney disease and hypertension. Embryos lacking the p53-E3 ubiquitin ligase, Murine double minute 2 (Mdm2), die secondary to p53-mediated apoptosis
Rachel L Berry et al.
Disease models & mechanisms, 8(8), 903-917 (2015-06-03)
Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we
Débora M Cerqueira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(8), 3540-3554 (2017-04-28)
Low nephron endowment at birth has been associated with an increased risk for developing hypertension and chronic kidney disease. We demonstrated in an earlier study that conditional deletion of the microRNA (miRNA)-processing enzyme Dicer from nephron progenitors results in premature
Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with
Huang L, et al.
Neoplasia, 18(2), 71-81 (2016)
Claudia M García-Peña et al.
Frontiers in neuroanatomy, 8, 43-43 (2014-06-14)
The Nigrostriatal pathway (NSP) is formed by dopaminergic axons that project from the ventral midbrain to the dorsolateral striatum as part of the medial forebrain bundle. Previous studies have implicated chemotropic proteins in the formation of the NSP during development
Yu Leng Phua et al.
Physiological reports, 3(10) (2015-10-07)
MicroRNAs are small noncoding RNAs that post-transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in the nephron progenitor and ureteric bud lineage, little is understood about stromal miRNAs during kidney development. The renal stroma (marked
Karam Aboudehen et al.
American journal of physiology. Renal physiology, 302(8), F928-F940 (2012-01-13)
The tumor suppressor protein p53 is a short-lived transcription factor due to Mdm2-mediated proteosomal degradation. In response to genotoxic stress, p53 is stabilized via posttranslational modifications which prevent Mdm2 binding. p53 activation results in cell cycle arrest and apoptosis. We
J Luo et al.
Journal of neurochemistry, 72(6), 2286-2293 (1999-06-01)
The expression and activity of factors influencing early neuronal development are altered by ethanol. Such factors include growth factors, for example, platelet-derived growth factor and basic fibroblast growth factor (for cell proliferation), and cell adhesion molecules (for neuronal migration). One
Fenglin Wang et al.
Epigenetics, 16(11), 1235-1250 (2020-12-15)
The epigenetic regulator Dot1, the only known histone H3K79 methyltransferase, has a conserved role in organismal development and homoeostasis. In yeast, Dot1 is required for telomeric silencing and genomic integrity. In Drosophila, Dot1 (Grappa) regulates homoeotic gene expression. Dysregulation of
Le Huang et al.
Neoplasia (New York, N.Y.), 18(2), 71-81 (2016-03-05)
Wilms tumor, a common childhood tumor of the kidney, is thought to arise from undifferentiated renal mesenchyme. Variable tumor histology and the identification of tumor subsets displaying different gene expression profiles suggest that tumors may arise at different stages of
Aysegul Dilsizoglu Senol et al.
BMC neuroscience, 16, 10-10 (2015-04-17)
The amyloid precursor protein (APP) is a key molecule in Alzheimer disease. Its localization at the cell surface can trigger downstream signaling and APP cleavages. APP trafficking to the cell surface in neurons is not clearly understood and may be
Dylan Brethour et al.
Scientific reports, 7, 40313-40313 (2017-01-18)
The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding the function of PrP. Building on
Leah K Cuddy et al.
Neuron, 104(5), 869-884 (2019-10-28)
Age-related neurodegenerative disorders are characterized by a slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear how pathogenic proteins evade this process in disease. We find that
Stephanie Hum et al.
PloS one, 9(2), e88400-e88400 (2014-02-08)
The renal stroma is an embryonic cell population located in the cortex that provides a structural framework as well as a source of endothelial progenitors for the developing kidney. The exact role of the renal stroma in normal kidney development
Helen McNeill et al.
Journal of the American Society of Nephrology : JASN, 28(3), 852-861 (2016-09-21)
In the kidney, formation of the functional filtration units, the nephrons, is essential for postnatal life. During development, mesenchymal progenitors tightly regulate the balance between self-renewal and differentiation to give rise to all nephron epithelia. Here, we investigated the functions
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