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Showing 1-30 of 277 results for "C9891" within Papers
Lutian Yao et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(6), 1159-1173 (2021-02-03)
Skeletal muscle has remarkable regenerative ability after injury. Mesenchymal fibro-adipogenic progenitors (FAPs) are necessary, active participants during this repair process, but the molecular signatures of these cells and their functional relevance remain largely unexplored. Here, using a lineage tracing mouse
Lacey J Luense et al.
Developmental cell, 51(6), 745-758 (2019-11-26)
During mammalian spermatogenesis, germ cell chromatin undergoes dramatic histone acetylation-mediated reorganization, whereby 90%-99% of histones are evicted. Given the potential role of retained histones in fertility and embryonic development, the genomic location of retained nucleosomes is of great interest. However
Cynthia R Sides et al.
Journal of the American Society for Mass Spectrometry, 23(3), 505-519 (2011-12-31)
Pairing limited proteolysis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) to probe clostridial collagenase collagen binding domain (CBD) reveals the solution dynamics and stability of the protein, as these factors are crucial to CBD effectiveness as a
Thierry Cens et al.
Methods in molecular biology (Clifton, N.J.), 403, 287-302 (2008-10-02)
The Xenopus laevis oocyte is a widely used system for heterologous expression of exogenous ion channel proteins (1, 2). Among other advantages, these easy to obtain, mechanically and electrically stable, large-sized cells enable multiple types of electrophysiological recordings: two-electrode voltage-clamp
Maslin Osathanunkul et al.
Analytical biochemistry, 433(2), 168-170 (2012-10-18)
Coomassie brilliant blue (CBB) heated by microwave was used as a staining dye for measuring gelatinolytic activity. The quantity of gelatin remaining after incubation with bacterial collagenase was determined using the heated CBB, resulting in visible blue pellets. Dimethyl sulfoxide
E W McCleskey et al.
Annual review of physiology, 61, 835-856 (1999-04-01)
Nociceptors are the first cells in the series of neurons that lead to the sensation of pain. The essential functions of nociceptors--transducing noxious stimuli into depolarizations that trigger action potentials, conducting the action potentials from the peripheral sensory site to
Anne-Lou Touret et al.
Development (Cambridge, England), 149(19) (2022-09-29)
Hematopoietic stem and progenitor cells emerge from the aorta and migrate to the caudal hematopoietic tissue (CHT) of zebrafish larvae, the hematopoietic equivalent of the mammalian fetal liver, for their proliferation and differentiation. We previously reported that somite-derived stromal cells
Alison E Casey et al.
The Journal of cell biology, 217(8), 2951-2974 (2018-06-21)
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete.
M Dolores García-Fernández et al.
Cell reports methods, 1(8), None-None (2022-01-04)
Ligand-gated ion channels (LGICs) are natural biosensors generating electrical signals in response to the binding of specific ligands. Creating de novo LGICs for biosensing applications is technically challenging. We have previously designed modified LGICs by linking G protein-coupled receptors (GPCRs)
M D Bond et al.
Biochemistry, 23(13), 3085-3091 (1984-06-19)
The six collagenases (alpha, beta, gamma, delta, epsilon, and zeta) from Clostridium histolyticum isolated in the preceding paper [Bond, M. D., & Van Wart, H. E. (1984) Biochemistry (first paper of three in this issue)] have been characterized in detail.
Jörg Witthaut et al.
Clinical drug investigation, 31(11), 791-798 (2011-10-05)
Injectable collagenase Clostridium histolyticum is efficacious in correcting Dupuytren's contracture as assessed by changes in the angle of contracture and range of motion (ROM). However, clinically important changes in ROM have not been evaluated in depth. The objective of this
Ariane Nimptsch et al.
Cell and tissue research, 343(3), 605-617 (2011-01-29)
Collagens are the most abundant proteins in vertebrate tissues and constitute significant moieties of the extracellular matrix (ECM). The determination of the collagen content is of relevance not only in the field of native tissue research, but also regarding the
Sedat Odabas et al.
Methods in molecular biology (Clifton, N.J.), 1109, 47-63 (2014-01-30)
Mesenchymal stem cells (MSCs) have drawn great interest in the field of regenerative medicine, for cell replacement, immunomodulatory, and gene therapies. It has been shown that these multipotent stromal cells can be isolated from tissues such as bone marrow, adipose
Cosmin Cătălin Mustăciosu et al.
International journal of molecular sciences, 20(8) (2019-04-25)
The neuron-specific Elav-like Hu RNA-binding proteins were described to play an important role in neuronal differentiation and plasticity by ensuring the post-transcriptional control of RNAs encoding for various proteins. Although Elav-like Hu proteins alterations were reported in diabetes or neuropathy
Re: clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies: M. Gelbard, I. Goldstein, W. J. Hellstrom, C. G. McMahon, T. Smith, J. Tursi, N. Jones, G. J. Kaufman and C. C. Carson, III J Urol 2013; 190: 199-207.
S Jain et al.
The Journal of urology, 191(2), 561-563 (2013-11-19)
J R Merkel et al.
Biochemistry, 17(14), 2857-2863 (1978-07-11)
A true collagenase was isolated from the culture fluid of a marine bacterium which has been designated Vibrio B-30 (ATCC 21250). Collagenase production was obtained only in media containing collagen or certain degradation products of collagen. Partial purification on DEAE-cellulose
Aleksandra Wroblewska et al.
Cell, 175(4), 1141-1155 (2018-10-23)
CRISPR pools are being widely employed to identify gene functions. However, current technology, which utilizes DNA as barcodes, permits limited phenotyping and bulk-cell resolution. To enable novel screening capabilities, we developed a barcoding system operating at the protein level. We
Swati Sharma et al.
PloS one, 14(6), e0218194-e0218194 (2019-06-22)
From a biological and clinical perspective, it is imperative to establish primate spermatogonial cultures. Due to limited availability of human testicular tissues, the macaque (Macaca fascicularis) was employed as non-human primate model. The aim of this study was to characterize
Xu Yang et al.
Oxidative medicine and cellular longevity, 2020, 3921897-3921897 (2020-11-17)
Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis
Jeppe Nørgaard Poulsen et al.
Experimental cell research, 336(1), 94-99 (2015-05-23)
Communications between satellite glial cells and neighboring neurons within sensory ganglia may contribute to neuropathic and inflammatory pain. To elucidate the role of satellite glial cells in chemotherapy-induced pain, we examined the effects of oxaliplatin on the gap junction-mediated coupling
Sébastien J Dumas et al.
STAR protocols, 2(3), 100523-100523 (2021-08-13)
Endothelial cells (ECs) exhibit phenotypic and functional tissue specificities, critical for studies in the vascular field and beyond. Thus, tissue-specific methods for isolation of highly purified ECs are necessary. Kidney, spleen, and testis ECs are relevant players in health and
Zuzana Koledova
Methods in molecular biology (Clifton, N.J.), 1612, 107-124 (2017-06-22)
Mammary gland is composed of branched epithelial structure embedded within a complex stroma formed by several stromal cell types, including fibroblasts, and extracellular matrix (ECM). Development of mammary gland is tightly regulated by bidirectional epithelial-stromal interactions that include paracrine signaling
Anna Katharina Spohner et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuries. Here, we addressed the
Ivan Flores et al.
Human molecular genetics, 31(2), 189-206 (2021-08-16)
Leukemia inhibitory factor (LIF) can influence development by increasing cell proliferation and inhibiting differentiation. Because of its potency for expanding stem cell populations, delivery of exogenous LIF to diseased tissue could have therapeutic value. However, systemic elevations of LIF can
Skin laceration as a serious adverse sequela of injectable collagenase for Dupuytren contracture.
Geoffrey G Hallock
Plastic and reconstructive surgery, 129(1), 205e-206e (2011-12-22)
E Aysan et al.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 47(3), 130-134 (2011-08-19)
To evaluate the effect of clostridiopeptidase A collagenase (CAC) in a rat model of postoperative peritoneal adhesion (PPA). Forty rats were divided into four equal groups. In group 1, 1 g CAC was injected into the peritoneal cavity. In group
L Lacitignola et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 27(3), 204-209 (2014-04-26)
The aim of this study was to track the survival and efficacy of allogeneic bone marrow mesenchymal stem cells (BM-MSC) marked with red fluorescent protein (BM-MSCRFP) in an ovine model of collagenase-induced tendinopathy. Bone marrow was harvested from one donor
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.
Wang, et al.
Biology Open, 12 (2023)
Yufeng Si et al.
Marine biotechnology (New York, N.Y.), 21(1), 111-123 (2018-11-24)
Myoblast fusion is a vital step for skeletal muscle development, growth, and regeneration. Loss of Jamb, Jamc, or Myomaker (Mymk) function impaired myoblast fusion in zebrafish embryos. In addition, mymk mutation hampered fish muscle growth. However, the effect of Jamb
Boqiang Sun et al.
Nature microbiology, 6(5), 682-696 (2021-02-10)
MicroRNA miR-138, which is highly expressed in neurons, represses herpes simplex virus 1 (HSV-1) lytic cycle genes by targeting viral ICP0 messenger RNA, thereby promoting viral latency in mice. We found that overexpressed miR-138 also represses lytic processes independently of
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