D-920

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Showing 1-30 of 33 results for "D-920" within Papers

Fatality caused by a combined trimipramine-citalopram intoxication.

F Musshoff et al.

Forensic science international, 106(2), 125-131 (2000-02-09)

A 53-year-old woman who was diagnosed as suffering from depression was found dead in her bed. The autopsy revealed no morphological changes sufficient to explain death. Toxicological analysis was performed and the drugs trimipramine (2.33 mg/l), citalopram (4.81 mg/l) and

Distribution of trimipramine and its major metabolites in a fatal overdose case.

A D Fraser et al.

Journal of analytical toxicology, 11(4), 168-170 (1987-07-01)

A fatality following ingestion of the tricyclic antidepressant trimipramine (Surmontil) is described. Quantitation was performed by high-performance liquid chromatography. Trimipramine and desmethyltrimipramine concentrations were 4.8 and 2.1 mg/L, respectively, in postmortem blood. The concentration of trimipramine, desmethyltrimipramine, and their respective

Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection.

D R Abernethy et al.

Clinical pharmacology and therapeutics, 35(3), 348-353 (1984-03-01)

Kinetic parameters were derived from trimipramine and desmethyltrimipramine plasma concentrations after administration of intravenous (12.5 mg) and oral (50 mg) trimipramine in nine subjects. Elimination t1/2 after intravenous dosing was (mean +/- SE) 23 +/- 1.9 hr. Volume of distribution

Dose-dependent kinetics of trimipramine.

M N Musa

The Journal of clinical psychiatry, 50(8), 307-307 (1989-08-01)

Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.

Julia Kirchheiner et al.

Pharmacogenetics, 13(12), 721-728 (2003-12-04)

The tricyclic antidepressant trimipramine is one of the drugs with the most pronounced differences in pharmacokinetics caused by the CYP2D6 genetic polymorphism. However, the effect of CYP2D6 genotype on steady state kinetics and on bioavailability has not been studied so

Quantitation of trimipramine enantiomers in human serum by enantioselective high-performance liquid chromatography and mixed-mode disc solid-phase extraction.

J Liu et al.

Journal of chromatography. B, Biomedical sciences and applications, 700(1-2), 175-182 (1997-12-09)

A sensitive and stereospecific method for the quantitation of trimipramine enantiomers in human serum was developed. The assay involves the use of a novel mixed-mode disc solid-phase extraction for serum sample clean-up prior to HPLC analysis and is also free

Simultaneous determination of trimipramine and its major metabolites by high-performance liquid chromatography.

A A Gulaid et al.

Journal of chromatography, 566(1), 228-233 (1991-05-03)

Trimipramine is a tricyclic antidepressant drug often assayed by gas chromatographic or gas chromatographic-mass spectrometry techniques. A high-performance liquid chromatographic method with electrochemical detection is described for the assay of trimipramine and its major metabolites, monodesmethyltrimipramine and 2-hydroxytrimipramine, in plasma.

[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure].

J Degen et al.

Medizinische Klinik (Munich, Germany : 1983), 88(3), 129-133 (1993-03-15)

The pharmacokinetics of the antidepressants amitriptyline oxide and trimipramine and their major metabolites amitriptyline, nor-triptyline and desmethyltrimipramine, were studied in twelve healthy male subjects (aged from 22 to 62 years) and twelve patients (aged from 25 to 73 years) with

In vitro metabolism of desmethyltrimipramine to yield hydroxylamino compound.

S Ozkirimli et al.

Acta pharmaceutica Suecica, 23(1), 57-59 (1986-01-01)

Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection.

N Jourdil et al.

Journal of chromatography, 613(1), 59-65 (1993-03-05)

A simple procedure is described that permits the simultaneous determination of trimipramine and its two major metabolites, desmethyl- and hydroxytrimipramine, in human plasma or red blood cells (RBCs) at therapeutic concentrations. The extracted biological fluids are injected into a capillary

Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites.

C B Eap et al.

Therapeutic drug monitoring, 14(5), 380-385 (1992-10-01)

A two-step high-performance liquid chromatography method is described, using a CN column and an alpha 1-acid glycoprotein column, which allows the measurement of the enantiomers of the hydroxy metabolites of trimipramine in plasma of trimipramine-treated patients. Of the four patients

Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.

C Pifl et al.

European journal of pharmacology, 146(1), 189-191 (1988-01-27)

Endothelial mediated inhibition of contraction and increase in cyclic GMP levels evoked by the alpha-adrenoceptor agonist B-HT 920 in rat isolated aorta.

R C Miller et al.

British journal of pharmacology, 83(4), 903-908 (1984-12-01)

In the presence of endothelium maximal contractions of rat aorta preparations evoked by B-HT 920 were about 10% of those evoked in the absence of endothelium. 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)azepin dihydrochloride (B-HT 920, 0.1 microM to 0.1 mM) induced concentration-dependent contractions of rat

The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors.

J J Beckeringh et al.

European journal of pharmacology, 104(3-4), 197-203 (1984-09-17)

The alpha-adrenergic action of the selective alpha 2-adrenoceptor agonists B-HT 920 and UK 14,304 was investigated on helically cut preparations of rat and guinea-pig isolated aorta. The alpha 1-adrenoceptor selective stimulant (-)-phenylephrine was included for comparison. All agonists induced concentration-dependent

Identification of the dopamine autoreceptor in the guinea-pig retina as D(2) receptor using novel subtype-selective antagonists.

B Weber et al.

British journal of pharmacology, 133(8), 1243-1248 (2001-08-11)

1. Dopamine release in the retina is subject to modulation via autoreceptors, which belong to the D(2) receptor family (encompassing the D(2), D(3) and D(4) receptors). The aim of the present study was to determine the receptor subtype (D(2) vs

Substrate specificity of a recombinant D-lyxose isomerase from Providencia stuartii for monosaccharides.

Hyun-Jung Kwon et al.

Journal of bioscience and bioengineering, 110(1), 26-31 (2010-06-15)

The specific activity and catalytic efficiency (k(cat)/K(m)) of the recombinant putative protein from Providencia stuartii was the highest for D-lyxose among the aldose substrates, indicating that it is a D-lyxose isomerase. Gel filtration analysis suggested that the native enzyme is

Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity.

Toshiaki Imagawa et al.

The Journal of biological chemistry, 280(19), 18736-18744 (2005-03-15)

The highly conserved amino acids of rat Na,K-ATPase, Thr-774 in the transmembrane helices M5, Val-920 and Gln-923 in M8, and Glu-953 and Glu-954 in M9, the side chains of which appear to be in close proximity, were mutated, and the

A short sequence within domain C of duck carboxypeptidase D is critical for duck hepatitis B virus binding and determines host specificity.

H C Spangenberg et al.

Journal of virology, 75(22), 10630-10642 (2001-10-17)

Virus-cell surface receptor interactions are of major interest. Hepadnaviruses are a family of partially double-stranded DNA viruses with liver tropism and a narrow host range of susceptibility to infection. At least in the case of duck hepatitis B virus (DHBV)

alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator.

K Orito et al.

British journal of pharmacology, 134(4), 763-770 (2001-10-19)

1. Antagonistic properties of OPC-28326 ([4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl)] piperidine hydrochloride monohydrate), a selective peripheral vasodilator, were investigated by analysing the data from functional studies in various tissues from the rat and binding studies of the drug to alpha(2)-adrenoceptor subtypes. 2. Using a

Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates.

Christina Chan et al.

Pharmacology research & perspectives, 5(5) (2017-10-04)

Protein synthesis inhibitors are commonly used for measuring protein degradation rates, but may cause cytotoxicity via direct or indirect mechanisms. This study aimed to identify concentrations providing optimal inhibition in the absence of overt cytotoxicity. Actinomycin D, cycloheximide, emetine, and

Molar absorptivities of 2,4-D, cymoxanil, fenpropidin, isoproturon and pyrimethanil in aqueous solution in the near-UV.

Valérie Feigenbrugel et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 63(1), 103-110 (2005-11-01)

The absorption spectra of five pesticides, namely 2,4-dichloro-phenoxy acetic acid (2,4-D), cymoxanil, fenpropidin, isoproturon and pyrimethanil, have been measured in aqueous solution using a set-up consisting of two parallel absorption cells coupled to a CCD detector. The absolute values of

Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca.

Beatriz Civantos et al.

European journal of pharmacology, 489(1-2), 101-110 (2004-04-06)

It has been suggested that the combination of dietary Ca and Ca2+ channel antagonists could have a synergic antihypertensive effect. In this study, 3-week-old male spontaneously hypertensive rats (SHR) were randomized into four groups of animals. Two of these groups

Pharmacological characterization of alpha-adrenoceptors that mediate contraction in splenic artery strips from the pig.

A Barbieri et al.

Naunyn-Schmiedeberg's archives of pharmacology, 357(6), 654-661 (1998-08-01)

The alpha-adrenoceptors that mediate contractions in strips of splenic artery from the pig were characterized by the use of selective agonists and subtype-selective antagonists. Noradrenaline, the alpha1-selective agonist phenylephrine and the alpha1-/alpha2-agonist oxymetazoline caused the preparations to contract with potency

Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin.

Caren E Smith et al.

The Journal of nutrition, 138(10), 1852-1858 (2008-09-23)

Perilipin (PLIN) is the major protein surrounding lipid droplets in adipocytes and regulates adipocyte metabolism by modulating the interaction between lipases and triacylglycerol stores. Associations between PLIN gene polymorphisms and obesity risk have been described, but interactions with dietary macronutrients

Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies.

Nathalie Ménard et al.

Pharmaceutical research, 29(7), 1882-1896 (2012-03-28)

Novel surfactants made of diglutamic acid (DG) polar head linked to lithocholic, arachidonic, linoleic or stearic acids were designed for drug solubilization. Surfactants 3-D conformer and packing parameter were determined by molecular modelling and self-assembling properties by pyrene fluorescence measurements.

Continuous production of lactulose by immobilized thermostable beta-glycosidase from Pyrococcus furiosus.

J Mayer et al.

Journal of biotechnology, 145(4), 387-393 (2009-12-29)

A continuous enzymatic process for the production of the prebiotic disaccharide lactulose through transgalactosylation was developed using free and immobilized beta-glycosidase from Pyrococcus furiosus. The hyperthermostable beta-glycosidase (CelB) was immobilized onto an anion-exchange resin (Amberlite IRA-93) or onto Eupergit C

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.

J V van Vliet-Ostaptchouk et al.

Diabetologia, 50(1), 59-62 (2006-10-13)

A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant

Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models.

Anton Malkov et al.

Annals of neurology, 85(6), 907-920 (2019-04-03)

Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to antiseizure drugs, with effective drug development impeded by lack of understanding on how seizures are initiated. Here, we report the mechanism of seizure onset relevant to most seizures

Rapid Bacteria Detection at Low Concentrations Using Sequential Immunomagnetic Separation and Paper-Based Isotachophoresis.

Federico Schaumburg et al.

Analytical chemistry, 91(15), 9623-9630 (2019-07-10)

Detecting bacteria is important in the fields of human health, environmental monitoring, and food safety. Foodborne pathogens alone are estimated to cause 420 000 deaths annually, with low-income regions affected most. Despite improvements in bacterial detection, fast, disposable, low-cost, sensitive, and

Methane emission, digestive characteristics and faecal archaeol in heifers fed diets based on silage from brown midrib maize as compared to conventional maize.

Angela Schwarm et al.

Archives of animal nutrition, 69(3), 159-176 (2015-05-13)

The aim of the present experiment was to compare silage prepared from maize having a brown midrib (BMR) mutation with control (CTR) maize to identify their effects on enteric methane emission, digesta mean retention time (MRT), ruminal fermentation and digestibility.

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