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Showing 1-30 of 217 results for "D4527" within Papers
Michelle C W Tang et al.
PLoS genetics, 11(2), e1004964-e1004964 (2015-02-13)
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic
A Iu Konev et al.
Tsitologiia, 55(3), 198-203 (2013-06-26)
This article presents an analysis of the causes of chromatin decompaction of interbands in Drosophila polytene chromosomes. On the example of interband 3C6/C7 of X chromosome, we investigate the ability of different DNA segments from the region to form an
Jonathan DeGeer et al.
Cell reports, 40(13), 111413-111413 (2022-09-29)
Efficient myelination supports nerve conduction and axonal health throughout life. In the central nervous system, oligodendrocytes (OLs) carry out this demanding anabolic duty in part through biosynthetic pathways controlled by mTOR. We identify Ral GTPases as critical regulators of mouse
Grigorios Georgolopoulos et al.
Nature communications, 12(1), 6790-6790 (2021-11-25)
Lineage commitment and differentiation is driven by the concerted action of master transcriptional regulators at their target chromatin sites. Multiple efforts have characterized the key transcription factors (TFs) that determine the various hematopoietic lineages. However, the temporal interactions between individual
Yanni Ge et al.
Molecular therapy. Nucleic acids, 26, 1201-1214 (2021-12-03)
DNA methylation is considered to play an important role in the development of diabetic retinopathy. Here, our goal was to investigate the precise role of methyl-CpG binding domain protein 2 (Mbd2) in the apoptosis of retinal ganglion cells (RGCs) in
Jingli Cao et al.
G3 (Bethesda, Md.) (2021-03-22)
Intellectual disability is closely related to impaired GABA neurotransmission. Brpf1 was specifically expressed in medial ganglionic eminence (MGE), a developmental niche of GABAergic interneurons, and patients with BRPF1 mutations showed intellectual disability. To test its role in development and function
[NETs in pathogenesis of vasculitis].
Daigo Nakazawa et al.
Nihon Jinzo Gakkai shi, 56(2), 117-123 (2014-04-16)
Yougui Xiang et al.
Journal of immunology (Baltimore, Md. : 1950), 190(4), 1819-1826 (2013-01-09)
The processes of Ig gene locus contraction and looping during V(D)J-recombination are essential for creating a diverse Ab repertoire. However, no cis-acting sequence that plays a major role in specifying locus contraction has been uncovered within the Igκ gene locus.
Deanna Bousalis et al.
Frontiers in cardiovascular medicine, 7, 93-93 (2020-06-18)
Congenital heart disease (CHD) affects almost one percent of all live births. Despite diagnostic and surgical reparative advances, the causes and mechanisms of CHD are still primarily unknown. The extracellular matrix plays a large role in cell communication, function, and
Maria de Fátima Martins et al.
European journal of histochemistry : EJH, 64(2) (2020-05-08)
Sialic acids, particularly N-acetylneuraminic acid (Neu5Ac), are present as terminal components of rich and complex oligosaccharide chains, which are termed glycans, and are exhibited on the cell surfaces, especially on epithelial cells. Crucial in the 'social behavior' of the cell
Wei Tao et al.
Science translational medicine, 12(553) (2020-07-29)
Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering RNA (siRNA) nanoparticle (NP) platform
Maria V Rogacheva et al.
The Journal of biological chemistry, 289(9), 5664-5673 (2014-01-10)
Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails
Daniel J Gaffney et al.
PLoS genetics, 8(11), e1003036-e1003036 (2012-11-21)
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to
Henrik Ahlenius et al.
Methods in molecular biology (Clifton, N.J.), 633, 241-252 (2010-03-06)
Neural stem cells are defined as cells that either gives rise to or derives from the cells of the central nervous system and have the unique properties of stem cells, i.e. self-renewal and multipotentiality. One of the widely used methods
Liang Lou et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(39), e2203273119-e2203273119 (2022-09-20)
Microglia are the central nervous system (CNS)-resident macrophages involved in neural inflammation, neurogenesis, and neural activity regulation. Previous studies have shown that naturally occurring neuronal apoptosis plays a critical role in regulating microglial colonization of the brain in zebrafish. However
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/I?-catenin/YAP1 axis.
Zhao, et al.
iScience, 26, 106862-106862 (2023)
ES cell-mediated conditional transgenesis.
M Gertsenstein et al.
Methods in molecular biology (Clifton, N.J.), 185, 285-307 (2002-01-05)
Xiaohua Jiang et al.
Biology of reproduction, 92(3), 79-79 (2015-01-30)
CDH2 (cadherin 2, Neural-cadherin, or N-cadherin) is the predominant protein of testicular basal ectoplasmic specializations (basal ES; a testis-specific type of adhesion junction), one of the major cell junctions composing the blood-testis barrier (BTB). The BTB is found between adjacent
Sunkyung Kim et al.
Immunity, 53(4), 759-774 (2020-08-17)
Development and function of conventional dendritic cell (cDC) subsets, cDC1 and cDC2, depend on transcription factors (TFs) IRF8 and IRF4, respectively. Since IRF8 and IRF4 can each interact with TF BATF3 at AP1-IRF composite elements (AICEs) and with TF PU.1
Marco Gargaro et al.
Immunity, 55(6), 1032-1050 (2022-06-16)
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis
Vladimir Grubišić et al.
Cell reports, 32(10), 108100-108100 (2020-09-10)
Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the gastrointestinal tract, but the signaling processes that link immune activation with visceral hypersensitivity are unresolved. We hypothesized that enteric glia link the neural and immune systems of the gut
Pengcheng Ma et al.
Science advances, 8(39), eabq4736-eabq4736 (2022-10-01)
The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information processing in the brain, and ubiquitination is a key regulator for this biological process. However, the roles of E3 ubiquitin ligases in the regulation of AMPARs are poorly
P Pierre
Methods in molecular medicine, 64, 413-422 (2001-01-01)
The initiation and propagation of the immune responses is dependent on the ability of antigen-presenting cells (APC) to convert proteins into peptides, to load them intracellularly onto major histocompatibility complex (MHC), and then to deliver the peptide-MHC complexes to the
Yiling Zhang et al.
Neuron, 103(1), 39-51 (2019-05-28)
Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth-factor responsiveness in mature neurons by dedifferentiation, we overexpressed Lin28 in the retina. Lin28-treated retinas responded to insulin-like
Mapping of genomic clones by fluorescence in situ hybridization.
M A Leversha
Methods in molecular biology (Clifton, N.J.), 175, 109-127 (2001-07-21)
Aaron I Weiner et al.
Cell reports, 41(11), 111805-111805 (2022-12-15)
The lung exhibits a robust, multifaceted regenerative response to severe injuries such as influenza infection, during which quiescent lung-resident epithelial progenitors participate in two distinct reparative pathways: functionally beneficial regeneration via alveolar type 2 (AT2) cell proliferation and differentiation, and
Hae Yon Jeon et al.
The EMBO journal, 41(8), e109365-e109365 (2022-03-15)
Tissue homeostasis requires lineage fidelity of stem cells. Dysregulation of cell fate specification and differentiation leads to various diseases, yet the cellular and molecular mechanisms governing these processes remain elusive. We demonstrate that YAP/TAZ activation reprograms airway secretory cells, which
Alison Coady et al.
Infection and immunity, 83(4), 1265-1275 (2015-01-15)
The ability of the innate immune system to trigger an adaptive T cell response is critical to resolution of infection with the fungal pathogen Histoplasma capsulatum. However, the signaling pathways and cell types involved in the recognition of and response
Patrick A Fardella et al.
Journal of fungi (Basel, Switzerland), 8(10) (2022-10-28)
Dollar spot disease, caused by the fungal pathogen Clarireedia jacksonii, is a major problem in many turfgrass species, particularly creeping bentgrass (Agrostis stolonifera). It is well-established that strong creeping red fescue (Festuca rubra subsp. rubra) exhibits good dollar spot resistance
Wei Zheng et al.
Genes, 10(12) (2019-11-30)
Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade
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