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Showing 1-24 of 24 results for "D4911" within Papers
Parisa Yousefpour et al.
International journal of nanomedicine, 6, 1487-1496 (2011-07-29)
This study deals with the preparation and investigation of a nanoscale delivery system for the anticancer drug doxorubicin (DOX) using its complexation with polyanionic carbohydrate dextran sulfate (DS). Dynamic light scattering, SEM, and zeta potential determination were used to characterize
Radiotherapy, Surgery, and Immunotherapy (2012)
Rheology of Industrial Polysaccharides: Theory and Applications (2012)
N R Popova et al.
Molecules (Basel, Switzerland), 25(13) (2020-07-02)
Cerium oxide nanoparticles (nanoceria) are believed to be the most versatile nanozyme, showing great promise for biomedical applications. At the same time, the controlled intracellular delivery of nanoceria remains an unresolved problem. Here, we have demonstrated the radioprotective effect of
Erik C Gunther et al.
Cell reports, 26(1), 145-158 (2019-01-04)
Cellular prion protein (PrPC) binds the scrapie conformation of PrP (PrPSc) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer's disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrPC interaction with Aβo.
Sebastian Strauss et al.
Nature methods, 15(9), 685-688 (2018-08-22)
Although current implementations of super-resolution microscopy are technically approaching true molecular-scale resolution, this has not translated to imaging of biological specimens, because of the large size of conventional affinity reagents. Here we introduce slow off-rate modified aptamers (SOMAmers) as small
Jinsung Hong et al.
Biotechnology progress, 35(5), e2831-e2831 (2019-05-03)
An alternating tangential flow (ATF) perfusion-based transient gene expression (TGE) bioprocess has been developed using human embryonic kidney (HEK) 293 cells to produce H1-ss-np, a promising candidate for a universal influenza vaccine. Two major adjustments were taken to improve the
Radiotherapy, Surgery, and Immunotherapy (2012)
Structural features and anticancer activity in vitro of fucoidan derivatives from brown alga Saccharina cichorioides
Anastyuk SD, et al.
Carbohydrate Polymers, 157, 1503-1510 (2017)
Determination of residual dextran sulfate in protein products by SEC-HPLC
Tazi LM and Jayawickreme S
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1011, 89-93 (2016)
Yuli Talyansky et al.
PLoS pathogens, 17(2), e1009291-e1009291 (2021-02-03)
Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of virulence in A. baumannii remain uncertain. By comparing genomes among a panel of A. baumannii strains we identified a specific gene
Profiling the transcriptome with RNA SPOTs
Eng CHL, et al.
Nature Methods, 14(12), 1153-1153 (2017)
Ex vivo Ooplasmic Extract from Developing Drosophila Oocytes for Quantitative TIRF Microscopy Analysis
Gaspar I and Ephrussi A
Bio-protocol, 7(13), 1153-1153 (2017)
Stanislav D Anastyuk et al.
Carbohydrate polymers, 157, 1503-1510 (2016-12-19)
A fucoidan ScF from brown alga Saccharina cichorioides was extracted, purified and partially depolymerized by autohydrolysis at 37°C for 24, 48 and 72h. Supernatant (SN) and pellet (PL) fractions were obtained by ethanol precipitation of each sample. Unlike spectral data
Sofia A Quinodoz et al.
Cell, 174(3), 744-757 (2018-06-12)
Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current methods for studying genome-wide structure are based on proximity ligation. However, this approach can fail to detect known structures, such as interactions with nuclear bodies, because these DNA
Camilla Gustafsen et al.
Nature communications, 8(1), 503-503 (2017-09-13)
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degradation of the LDL receptor (LDLR) in the
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and
The Molecular Biology of Poliovirus (2012)
Valter R M Lombardi et al.
Journal of biomedicine & biotechnology, 2012, 826178-826178 (2012-05-24)
One of the main treatments currently used in humans to fight cancer is chemotherapy. A huge number of compounds with antitumor activity are present in nature, and many of their derivatives are produced by microorganisms. However, the search for new
Nicoletta Giamblanco et al.
Analytical chemistry, 90(21), 12900-12908 (2018-09-07)
Amyloid fibrils are involved in several neurodegenerative diseases. However, because of their polymorphism and low concentration, they are challenging to assess in real-time with conventional techniques. Here, we present a new approach for the characterization of the intermediates: protofibrils and
A fucoidan fraction purified from Chnoospora minima; a potential inhibitor of LPS-induced inflammatory responses
Fernando IPS, et al.
International Journal of Biological Macromolecules, 104, 1185-1193 (2017)
Chee-Huat Linus Eng et al.
Nature methods, 14(12), 1153-1155 (2017-11-14)
Single-molecule FISH (smFISH) has been the gold standard for quantifying individual transcript abundances. Here, we scale up multiplexed smFISH to the transcriptome level and profile 10,212 different mRNAs from mouse fibroblast and embryonic stem cells. This method, called RNA sequential
The Molecular Biology of Poliovirus (2012)
Chee-Huat Linus Eng et al.
Nature, 568(7751), 235-239 (2019-03-27)
Imaging the transcriptome in situ with high accuracy has been a major challenge in single-cell biology, which is particularly hindered by the limits of optical resolution and the density of transcripts in single cells1-5. Here we demonstrate an evolution of
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