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Showing 1-8 of 8 results for "D5314" within Papers
M J Suto et al.
Anti-cancer drug design, 6(2), 107-117 (1991-05-01)
A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the amide with respect to the substituent on
M J Eliasson et al.
Nature medicine, 3(10), 1089-1095 (1997-10-23)
Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defined. One candidate pathway is DNA damage leading to activation of
Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids
Ahmed EA, et al.
Mutation Research, 683(1), 84-90 (2010)
Ujval Anilkumar et al.
PloS one, 12(11), e0188343-e0188343 (2017-11-18)
Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically and genetically activated cell death pathways in excitotoxic injury, the factors mediating
Emad A Ahmed et al.
Mutation research, 683(1-2), 84-90 (2009-11-06)
The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently regulated compared to that in somatic cells. Round spermatids show DSB repair and are radioresistant to apoptosis induction. Mutation induction studies using ionizing irradiation
Emad A Ahmed et al.
International journal of molecular sciences, 16(12), 29923-29935 (2015-12-24)
Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence, genomic damage may accumulate in sperm and be transmitted to the zygote. Indirect, delayed DNA fragmentation and lesions
Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses, 29-29 (2012)
Emad A Ahmed et al.
DNA and cell biology, 40(2), 209-218 (2020-12-19)
Poly (ADP-ribose) polymerase-1 (Parp1) is a member of nuclear enzymes family involved in to the response to genotoxic stresses, DNA repair, and is critical for the maintenance of genome stability. During gametogenesis, genome stability is essential for inheritance and formation
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