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Showing 1-30 of 215 results for "D5758" within Papers
Shang-Tao Chien et al.
Oncology reports, 34(2), 961-971 (2015-06-18)
Bcl2L12 plays a role in post-mitochondrial apoptosis through multiple mechanisms involving p53, αB-crystallin, caspase-3 and -7 in glioblastoma. Bcl2L12 is reported to be a good prognostic marker in breast cancer and correlated with ER and Bcl2 expression status. However, the
Anna C Denicol et al.
PloS one, 10(7), e0133587-e0133587 (2015-07-22)
Sex affects function of the developing mammalian embryo as early as the preimplantation period. There were two goals of the current objective. The first was to determine the degree and nature of differences in gene expression between female and male
J Fichna et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(11), 1539-1550 (2014-07-22)
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal (GI) disorder, defined by the presence of loose stools and abdominal pain. In search for a novel anti-IBS-D therapy, here we investigated the nociceptin receptor (NOP)-dependent effects in the GI tract.
Bingjie Cai et al.
Biosensors & bioelectronics, 74, 329-334 (2015-07-15)
Early detection is proven to be the best chance for successful cancer treatment. MiRNAs, as ideal biomarkers, can identify cancer in the early stage. Therefore, development of highly sensitive and selective detection methods for miRNA is still anticipated. Here we
Zhiyong Xie et al.
eLife, 10 (2021-07-29)
Sensorimotor transformation, a process that converts sensory stimuli into motor actions, is critical for the brain to initiate behaviors. Although the circuitry involved in sensorimotor transformation has been well delineated, the molecular logic behind this process remains poorly understood. Here
J M Zuehlke et al.
Annual review of food science and technology, 4, 57-78 (2012-12-12)
Understanding the characteristics of yeast spoilage, as well as the available control technologies, is vital to producing consistent, high-quality wine. Zygosaccharomyces bailii contamination may result in refermentation and CO2 production in sweet wines or grape juice concentrate, whereas Brettanomyces bruxellensis
Evelina Miele et al.
Molecular oncology, 15(2), 523-542 (2020-09-14)
Persistent mortality rates of medulloblastoma (MB) and severe side effects of the current therapies require the definition of the molecular mechanisms that contribute to tumor progression. Using cultured MB cancer stem cells and xenograft tumors generated in mice, we show
Zhou Liu et al.
Cell transplantation, 24(7), 1265-1281 (2014-05-27)
Transplantation of bone marrow mesenchymal stem cells (MSCs) promotes functional recovery in multiple sclerosis (MS) patients and in a murine model of MS. However, there is only a modicum of information on differentiation of grafted MSCs into oligodendrocyte-like cells in
Serological and Molecular Investigation of Swine Hepatitis E Virus in Pigs Raised in Southern Italy.
Nicola Costanzo et al.
Journal of food protection, 78(11), 2099-2102 (2015-11-12)
Hepatitis E virus (HEV) infection is a common acute hepatitis transmitted by the fecal-oral route. In developed countries, the virus has a zoonotic potential, and domestic pigs and wild boars are considered main reservoirs. To assess the prevalence of HEV-positive
Alice Chaplin et al.
PloS one, 10(4), e0125091-e0125091 (2015-04-29)
The gastrointestinal tract constitutes a physiological interface integrating nutrient and microbiota-host metabolism. Conjugated linoleic acids (CLA) have been reported to contribute to decreased body weight and fat accretion. The modulation by dietary CLA of stomach proteins related to energy homeostasis
Lena Schreiber et al.
G3 (Bethesda, Md.), 4(10), 1797-1811 (2014-08-02)
Starch accumulation and breakdown are vital processes in plant storage organs such as seeds, roots, and tubers. In tubers of potato (Solanum tuberosum L.) a small fraction of starch is converted into the reducing sugars glucose and fructose. Reducing sugars
P C Lopes et al.
Biochemical pharmacology, 91(1), 61-73 (2014-06-25)
Cyclosporine A (CsA) and sirolimus (SRL) are immunosuppressive agents (IA) associated with new-onset diabetes after transplantation (NODAT). This study aims to evaluate the effects of 3-weeks of treatment with either CsA (5 mg/kg BW/day) or SRL (1 mg/kg BW/day) on
Hyundong Yoo et al.
Archives of pharmacal research, 38(1), 129-136 (2014-04-02)
Despite the preferable properties of well-defined cationic peptides for small interfering RNA (siRNA) delivery, their application as siRNA carriers remains limited due to their poor binding affinity with short-chain RNAs. In this study, we investigated the feasibility of a novel
Chang-Jun Li et al.
The Journal of clinical investigation, 125(4), 1509-1522 (2015-03-10)
Bone marrow mesenchymal stem cells (BMSCs) exhibit an age-dependent reduction in osteogenesis that is accompanied by an increased propensity toward adipocyte differentiation. This switch increases adipocyte numbers and decreases the number of osteoblasts, contributing to age-related bone loss. Here, we
X Y Ma et al.
Fish physiology and biochemistry, 41(4), 937-950 (2015-05-06)
We evaluated the effects of rearing temperature on the composition of fatty acids and stearoyl-CoA desaturase (SCD) activity and gene expression in GIFT (genetically improved farmed tilapia) tilapia. Three triplicate groups of fish were reared for 40 days at 22, 28
Marcela Lipovsek et al.
STAR protocols, 1(3), 100146-100146 (2020-12-31)
Obtaining electrophysiological recordings and gene expression information from the same neuron (Patch-seq) brings forward a unique opportunity to study the transcriptional correlates of functional properties and vice versa. Here, we provide a detailed Patch-seq protocol tailored to the specialized demands
Marion Poirier et al.
ChemMedChem, 14(2), 224-236 (2018-12-07)
By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome
J I Cacho et al.
Journal of chromatography. A, 1380, 156-161 (2015-01-15)
A method using direct sample introduction (DSI) coupled to gas chromatography-mass spectrometry (GC-MS) is developed for the determination of six phthalate esters (dimethyl, diethyl, dibutyl, butylbenzyl, diethylhexyl and dioctyl phthalate) in cleaning products. The different variables involved in the DSI
Grete Lottrup et al.
European journal of endocrinology, 172(4), 491-499 (2015-01-23)
Testicular adrenal rest tumours (TARTs) are a common finding in patients with congenital adrenal hyperplasia (CAH). These tumours constitute a diagnostic and management conundrum and may lead to infertility. TART cells share many functional and morphological similarities with Leydig cells
Amber J Marty et al.
PLoS pathogens, 11(6), e1004959-e1004959 (2015-06-27)
In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA transcription factor, SREB, important for the transition to mold. Null
Anantharajappa Kumudha et al.
Food chemistry, 170, 316-320 (2014-10-13)
Vitamin B12 is among the most essential biomolecules required for crucial metabolic processes in humans. Vitamin B12 was extracted from Chlorella vulgaris biomass under aqueous conditions, partially purified by passing the extract through amberlite XAD-2, Sep-Pak columns, and further purified
Patrícia Pereira et al.
Journal of chromatography. A, 1368, 173-182 (2014-12-03)
MicroRNA-based therapeutic applications have fostered a growing interest in the development of microRNAs purification processes in order to obtain the final product with high purity degree, good quality and biologically active. The pre-miR-29 deficiency or overexpression has been associated to
Shanshan Zhang et al.
International journal of oncology, 46(4), 1589-1600 (2015-01-28)
Doxorubicin (DOX) is a key chemotherapeutic drug for cancer treatment. The antitumor mechanism of DOX is its action as a topoisomerase II poison by preventing DNA replication. Our study shows that DOX can be involved in epigenetic regulation of gene
Suresh Kumar et al.
The protein journal, 34(4), 284-290 (2015-08-06)
Plant seeds contain a number of proteins which play important roles in the protection and the process of germination of seeds. We have isolated and purified a 25 kDa protein from Kabuli Chana (Cicer arietinum L., Chickpea-white, CW-25). The CW-25 protein
Fajun Li et al.
General and comparative endocrinology, 216, 152-160 (2015-01-06)
Insulin-like androgenic gland hormone-binding protein (IAGBP) has been investigated in crustaceans in vitro. However, the relationship between IAGBP and its putative binding protein partner insulin-like androgenic gland hormone (IAG) has not been studied at the transcriptional level in vivo. In
Chenyang Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 879-888 (2014-06-13)
The impact of environmental stressors on the magnitude of specific chemokine gene expression was examined in mouse bone marrow-derived macrophages stimulated through various TLRs. Levels of TLR-stimulated CXCL1 and CXCL2 but not CXCL10 or CCL5 mRNAs were selectively enhanced (>10-fold)
Chi Young Shim et al.
Journal of diabetes investigation, 5(4), 362-371 (2014-11-21)
We aimed to examine the effect of an angiotensin II receptor blocker (ARB), a peroxisome proliferator-activated receptor (PPAR)-gamma agonist, and their combination on myocardial fibrosis and function in type 2 diabetic rats. Five male Long-Evans Tokushima Otsuka (LETO) rats and 20 male
Robert T Jeters et al.
Journal of bacteriology, 191(20), 6374-6382 (2009-08-25)
Many human colonic Bacteroides spp. harbor a conjugative transposon, CTnDOT, which carries two antibiotic resistance genes, tetQ and ermF. A distinctive feature of CTnDOT is that its excision and transfer are stimulated by tetracycline. Regulation of the genes responsible for
Elizabeth M Bafaro et al.
Metallomics : integrated biometal science, 7(9), 1319-1330 (2015-04-18)
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase the cytosolic concentration of zinc. hZIP4 transports zinc into intestinal cells and therefore has a central role in the absorption of dietary zinc. hZIP4 has eight
Alexandra Jung et al.
Applied and environmental microbiology, 81(2), 736-744 (2014-11-16)
The alphaproteobacterium Hyphomonas neptunium proliferates by a unique budding mechanism in which daughter cells emerge from the end of a stalk-like extension emanating from the mother cell body. Studies of this species so far have been hampered by the lack
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