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Showing 1-30 of 4409 results for "D8284" within Papers
Yuhong Huang et al.
Enzyme and microbial technology, 73-74, 9-19 (2015-05-24)
Specific enzymes from plant-pathogenic microbes demonstrate high effectiveness for natural lignocellulosic biomass degradation and utilization. The secreted lignocellulolytic enzymes of Fusarium species have not been investigated comprehensively, however. In this study we compared cellulose and hemicellulose-degrading enzymes of classical fungal
Hong Shen et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(7), 984-993 (2015-04-24)
The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion of creatinine and its exact localization in the kidney are reportedly controversial. In the present investigation, the transport of creatinine was assessed in human embryonic kidney (HEK)
Hydrogen sulfide inhibits transforming growth factor beta-1 induced bronchial epithelial-mesenchymal transition.
Cheng-Cheng Liao et al.
Chinese medical journal, 128(23), 3247-3250 (2015-11-28)
Daiki Murase et al.
Biology open, 4(10), 1213-1221 (2015-09-06)
Skin hyperpigmentation is characterized by increased melanin synthesis and deposition that can cause significant psychosocial and psychological distress. Although several cytokine-receptor signaling cascades contribute to the formation of ultraviolet B-induced cutaneous hyperpigmentation, their possible involvement in other types of skin
Angelo Blasio et al.
Behavioural brain research, 287, 315-322 (2015-04-08)
Sigma-1 receptor (Sig-1R) has been proposed as a novel therapeutic target for drug and alcohol addiction. We have shown previously that Sig-1R agonists facilitate the reinforcing effects of ethanol and induce binge-like drinking, while Sig-1R antagonists on the other hand
Baogang Zhang et al.
Cancer biology & therapy, 16(6), 898-911 (2015-04-15)
Glioma is the most common form of primary malignant brain cancers. Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. The invasive biological feature of glioma cell is stimulated by both autocrine and paracrine factors
Wei Xiang et al.
Oncotarget, 6(6), 4066-4079 (2015-02-26)
Inactivation of human SET domain containing protein 2 (SETD2) is a common event in clear cell renal cell carcinoma (ccRCC). However, the mechanism underlying loss of SETD2 function, particularly the post-transcriptional regulatory mechanism, still remains unclear. In the present study
Zexiong Guo et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(5), 3583-3589 (2015-01-07)
Recent evidence suggests that cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that acts as a novel therapeutic target in a variety of tumors. In this study, we investigated the clinical significance of CIP2A and its function in
Cuiping Li et al.
Tuberculosis (Edinburgh, Scotland), 95(5), 547-554 (2015-08-16)
Pulmonary tuberculosis (PTB) is a chronic disease and has remained a severe threat to public health. Valuable biomarkers for improving the detection rate are crucial for controlling this disease. The purpose of this study was to discover potential biomarkers in
Kristine Kloster-Jensen et al.
Transplant international : official journal of the European Society for Organ Transplantation, 28(10), 1152-1161 (2015-06-06)
Islet transplantation has become a promising treatment for type 1 diabetes. However, immunosuppressive drugs used today cause islet deterioration and modification strategies are necessary. But little is known about pharmacokinetics interactions and intracellular concentrations of immunosuppressive drugs in human islets.
Xiaohong Wang et al.
International journal of molecular medicine, 35(6), 1699-1707 (2015-04-16)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Semen Crotonis Pulveratum (SCP) has been used as a traditional medicine for the treatment of UC. However, its molecular mechanisms of action have not yet been elucidated. In the present study
Xuanhe Song et al.
Stem cells international, 2015, 926325-926325 (2015-04-09)
Meniscus reconstruction is in great need for orthopedic surgeons. Meniscal fibrochondrocytes transplantation was proposed to regenerate functional meniscus, with limited donor supply. We hypothesized that coculture of synovial mesenchymal stem cells (SSC) with meniscal fibrochondrocytes (me-CH) can support matrix production
Shiwei Duan et al.
Journal of cellular and molecular medicine, 19(5), 1077-1084 (2015-02-28)
DEFB126 rs140685149 mutation was shown to cause sperm dysfunction and subfertility. Indel rs11467497 is another 4-nucleotide frame-shift mutation (151bp upstream of rs140685149) that leads to the premature termination of translation and the expression of peptide truncated at the carboxyl terminus.
Guanghua Li et al.
Journal of cancer research and clinical oncology, 141(3), 443-452 (2014-09-30)
Inflammation plays an important role in gastric cancer (GC) development and progression. Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 negatively regulate proinflammatory cytokine signaling; however, their prognostic significance in GC remains unknown. We evaluated the clinicopathological correlation and prognostic significance
Kyoung-Tae Kim et al.
The spine journal : official journal of the North American Spine Society, 15(9), 2055-2065 (2015-04-30)
Substance P (SP) is a neuropeptide that can influence neural stem/progenitor cell (NSPC) proliferation and neurogenesis in the brain. However, we could not find any experimental study that investigates SP action in the spinal cord. The aims of our study
Raquel Martínez-Vega et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 418-432 (2014-11-12)
Nutritional imbalance is emerging as a causative factor of hearing loss. Epidemiologic studies have linked hearing loss to elevated plasma total homocysteine (tHcy) and folate deficiency, and have shown that folate supplementation lowers tHcy levels potentially ameliorating age-related hearing loss.
Zheng Hu et al.
Journal of dermatological science, 79(2), 155-162 (2015-05-20)
Malignant melanoma is a very refractory skin tumor due to its high metastasis, poor prognosis, and insensitivity to chemotherapy. Sonodynamic therapy has recently evolved as a potential method to treat cancers. In this study, 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) was
Hong Pei et al.
Molecular and cellular biochemistry, 400(1-2), 245-252 (2014-11-25)
Recent data strongly suggest the important role of miRNAs in various cancer-related processes. Osteosarcoma (OS) is the most common primary cancer of the bone and usually leads to deaths due to its rapid proliferation and metastasis. Here, we demonstrated that
Guohua Lou et al.
Journal of hematology & oncology, 8, 122-122 (2015-10-31)
Hepatocellular carcinoma (HCC) displays high resistance to conventional chemotherapy. Considering that microRNA-122 (miR-122) performs an essential function to promote chemosensitivity of HCC cells, an effective vehicle-mediated miR-122 delivery may represent a promising strategy for HCC chemotherapy. An increasing interest is
Jason Chesney et al.
Oncotarget, 5(16), 6670-6686 (2014-08-15)
Fructose-2,6-bisphosphate (F2,6BP) is a shunt product of glycolysis that allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose uptake and glycolytic flux to lactate. The F2,6BP concentration is dictated by four bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) with distinct kinase:phosphatase activities. PFKFB4 is over-expressed
L Jaatinen et al.
Annals of biomedical engineering, 43(4), 1014-1023 (2014-10-08)
Damage to the nervous system can be caused by several types of insults, and it always has a great effect on the life of an individual. Due to the limited availability of neural transplants, alternative approaches for neural regeneration must
De-hui Qian et al.
Vascular pharmacology, 72, 118-129 (2015-06-01)
To explore mir-542-3p mediated inhibition of vascular smooth muscle cell (VSMC) proliferation through the inhibition of Syk activation. MicroRNA (mir)-542-3p was selected for analysis based on miRNA microarray and qRT-PCR results. In vitro mir-542-3p expression was significantly downregulated in old
Fabian Birzele et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(12), 2753-2762 (2015-03-13)
CD44, a cell surface glycoprotein, plays important roles in the development, progression, and metastasis of various tumor types. The aim of this study was to investigate how the expression of CD44 isoforms influences the interaction with hyaluronic acid (HA) and
Tsurng-Juhn Huang et al.
Bioorganic & medicinal chemistry, 23(4), 720-728 (2015-01-21)
A series of novel isosteviol derivatives having C4-amide substituents were synthesized in order to test for antiviral effects against the hepatitis B virus (HBV) in vitro. Among them, IN-4 [N-(propylcarbonyl)-4α-amino-19-nor-ent-16-ketobeyeran] (5) exhibited inhibitory activity against secretion of HBsAg and HBeAg
Shoko Itakura et al.
The FEBS journal, 282(1), 142-152 (2014-10-16)
Antibodies against cytoplasmic proteins are useful tools that can control cellular function and clarify signaling mechanisms. However, it is difficult to capture proteins inside living cells, and thus appropriate methods for antibody delivery to the cytoplasm of living cells are
Chujie Bai et al.
Journal of experimental & clinical cancer research : CR, 34, 58-58 (2015-06-10)
Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell interactions, and signal transduction. These functions are highly correlated with cellular behaviors and contribute to resistances against chemo- and radio-therapies.
Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing.
Xue Gong et al.
PloS one, 10(6), e0130348-e0130348 (2015-06-20)
Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue, is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared with classical cellular monolayer, multicellular tumor spheroid (MCTS) offers a more rational platform to
Francisca O Gbormittah et al.
Bioanalysis, 6(19), 2537-2548 (2014-11-21)
Current analytical tools lack the required capacity to reduce the complexity of the plasma proteome and identify low-level proteins of clinical interest. Hence, the need to develop a fractionation approach to provide adequate throughput for a clinical study and minimize
Zhe Du et al.
Water research, 69, 110-119 (2014-12-03)
Despite the low nutrient level and constant presence of secondary disinfectants, bacterial re-growth still occurs in drinking water distribution systems. The molecular mechanisms that starved bacteria use to survive low-level chlorine-based disinfectants are not well understood. The objective of this
Celine M Op den Kamp et al.
Journal of cachexia, sarcopenia and muscle, 6(2), 164-173 (2015-07-03)
Cachexia augments cancer-related mortality and has devastating effects on quality of life. Pre-clinical studies indicate that systemic inflammation-induced loss of muscle oxidative phenotype (OXPHEN) stimulates cancer-induced muscle wasting. The aim of the current proof of concept study is to validate
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