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Showing 1-30 of 116 results for "D8406" within Papers
Xian Zhang et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(6), 1690-1700 (2019-04-13)
Mast cell (MC) deficiency in KitW-sh/W-sh mice and inhibition with disodium chromoglycate (DSCG) or ketotifen reduced obesity and diabetes in mice on a high-cholesterol (1.25%) Western diet. Yet, Kit-independent MC-deficient mice and mice treated with DSCG disproved MC function in
Dong Li et al.
Experimental and therapeutic medicine, 14(1), 874-880 (2017-07-05)
Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation.
Roberto Riquelme-Neira et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Mast cells (MCs) are involved in several immune-related responses, including those in bacterial infections, autoimmune diseases, inflammatory bowel diseases, and cancer, among others. MCs identify microorganisms by pattern recognition receptors (PRRs), activating a secretory response. Interleukin (IL)-10 has been described
Pengfei Zhang et al.
Nature communications, 13(1), 2298-2298 (2022-04-29)
Evanescent illumination has been widely used to detect single biological macromolecules because it can notably enhance light-analyte interaction. However, the current evanescent single-molecule detection system usually requires specially designed microspheres or nanomaterials. Here we show that single protein detection and
Mae-Xhum Wong et al.
Journal of immunology (Baltimore, Md. : 1950), 168(12), 6455-6462 (2002-06-11)
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a newly assigned member of the Ig-immunoreceptor tyrosine-based inhibitory motif superfamily, and its functional role is suggested to be an inhibitory receptor that modulates immunoreceptor tyrosine-based activation motif-dependent signaling cascades. In this study
Marie Tauber et al.
The Journal of experimental medicine, 220(10) (2023-07-18)
Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-associated functions. Here, we combined whole-tissue imaging and single-cell RNA sequencing datasets to generate a pan-organ analysis of MCs in mice and humans at steady state. In mice, we
Takeshi Kawahara
Animal science journal = Nihon chikusan Gakkaiho, 81(6), 714-721 (2010-11-27)
This study investigated the in vitro effect of Lactobacillus strains, a major group of probiotic lactic acid bacteria, on immunoglobulin E (IgE)- and antigen-induced mast cell degranulation and subsequent gene expression. Bone marrow-derived mast cells (BMMCs) from DBA/2 mice were
Monika Bambousková et al.
Methods in molecular biology (Clifton, N.J.), 2163, 293-310 (2020-08-09)
A better understanding of the molecular mechanisms leading to mast cell migration and chemotaxis is the long-term goal in mast cell research and is essential for comprehension of mast cell function in health and disease. Various techniques have been developed
Priscilia Lianto et al.
Food & nutrition research, 62 (2018-08-08)
Quail egg (QE) has been reported to possess an anti-allergic and anti-inflammatory activity. We have demonstrated that whole QE was able to attenuate the allergic symptoms in food allergy-induced EoE murine model, but whether QE albumen or QE yolk plays
Anna Rita Migliaccio et al.
The Journal of experimental medicine, 197(3), 281-296 (2003-02-05)
Here it is shown that the phenotype of adult mice lacking the first enhancer (DNA hypersensitive site I) and the distal promoter of the GATA-1 gene (neo Delta HS or GATA-1(low) mutants) reveals defects in mast cell development. These include
Carolin N Zorn et al.
Scientific reports, 8(1), 15467-15467 (2018-10-21)
Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central positive and negative
Chisato Honjoh et al.
Scientific reports, 7, 46064-46064 (2017-04-11)
Macrophage-inducible C-type lectin (Mincle) interacts with the γ-subunit of high-affinity IgE receptor (FcεRIγ) and activates Syk by recognizing its specific ligand, trehalose-6,6'-dimycolate, a glycolipid produced by Mycobacterium tuberculosis. It has been suggested that mast cells participate in the immune defense
Santosh K Mishra et al.
Cell reports, 31(1), 107472-107472 (2020-04-09)
Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice
Lakshmi Bhargavi Paruchuru et al.
Cells, 11(3) (2022-02-16)
In recent years, growing evidence has indicated the pivotal role of mitochondria in mast cell immunological activation. We have previously reported a decrease in degranulation and cytokine secretion following the inhibition of pyruvate dehydrogenase (PDH) either by CPI-613 (PDH inhibitor/anti-cancer
Michael Leitges et al.
Molecular and cellular biology, 22(12), 3970-3980 (2002-05-25)
Regulation of mast cell degranulation is dependent on the subtle interplay of cellular signaling proteins. The Src homology 2 (SH2) domain-containing inositol-5'-phosphatase (SHIP), which acts as the gatekeeper of degranulation, binds via both its SH2 domain and its phosphorylated NPXY
Hyper-IgE syndrome update.
Sowerwine KJ, et al.
Annals of the New York Academy of Sciences, 1250(1), 25-32 (2012)
Seth Malmersjö et al.
The EMBO journal, 35(16), 1810-1821 (2016-07-13)
Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an α-helical bundle to pull two membranes together. Here, we show that vesicle fusion can be suppressed by phosphorylation of core conserved residues inside the SNARE
Anastasiya Klebanovych et al.
Cells, 8(4) (2019-04-14)
The antigen-mediated activation of mast cells initiates signaling events leading to their degranulation, to the release of inflammatory mediators, and to the synthesis of cytokines and chemokines. Although rapid and transient microtubule reorganization during activation has been described, the molecular
Paulina Gorzelak-Pabis et al.
Postepy higieny i medycyny doswiadczalnej (Online), 71(0), 162-169 (2017-03-05)
Human vascular endothelial function and integrity may be regulated by many non-specific factors. However, the potential influence of specific antigens via an IgE-mediated mechanism remains unknown. The aim of the study was to determine the expression of the IgE receptors
Miji Yeom et al.
Molecules (Basel, Switzerland), 27(4) (2022-02-26)
Striae distensae (SD) or stretch marks are common linear scars of atrophic skin with disintegrating extracellular matrix (ECM) structures. Although fibroblasts contribute to the construction of ECM structure in SD, some studies have reported that mast cell degranulation causes the
Young Hwan Park et al.
Biomolecules & therapeutics, 27(3), 311-317 (2018-10-20)
Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory effects of CYC116 on the activation of mast cells and
Therapeutic effects of s-petasin on disease models of asthma and peritonitis.
Lee KP, et al.
Biomolecules & Therapeutics, 23(1), 45-45 (2015)
Immunoglobulin E.
William EW, et al.
Archives of Pathology & Laboratory Medicine, 124(9), 1382-1385 (2000)
Jae Yeon Lee et al.
Molecules (Basel, Switzerland), 25(17) (2020-09-06)
In the present study the effects and molecular mechanisms of wheat bran (WB), the hard outer layer of the wheat kernel used in food ingredients, on mast cell-mediated allergic responses in vitro and in vivo were investigated. The water extract
Laura Rojas Lorz et al.
Journal of ginseng research, 44(3), 453-460 (2020-05-07)
BIOGF1K, a fraction of Panax ginseng, has desirable antimelanogenic, anti-inflammatory, and antiphotoaging properties that could be useful for treating skin conditions. Because its potential positive effects on allergic reactions in skin have not yet been described in detail, this study's
Klaus Heger et al.
PLoS biology, 12(1), e1001762-e1001762 (2014-01-24)
Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-κB
Anaïs Wanet et al.
Science immunology, 6(56) (2021-02-07)
E-cadherin is a calcium-dependent cell-cell adhesion molecule extensively studied for its involvement in tissue formation, epithelial cell behavior, and suppression of cancer. However, E-cadherin expression in the hematopoietic system has not been fully elucidated. Combining single-cell RNA-sequencing analyses and immunophenotyping
The who, where, and when of IgE in allergic airway disease.
Dullaers M, et al.
The Journal of Allergy and Clinical Immunology, 129(3), 5024-5032 (2012)
Jie Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 3091-3104 (2020-01-08)
Allergic asthma with high plasma IgE levels is a significant risk factor of human abdominal aortic aneurysm (AAA). This study tests a direct role of IgE in angiotensin-II (Ang-II) perfusion- and peri-aortic CaCl2 injury-induced AAA in mice. In both models
Alessandro Angelin et al.
Polymers, 11(5) (2019-05-18)
Lipid-based membranes play crucial roles in regulating the interface between cells and their external environment, the communication within cells, and cellular sensing. To study these important processes, various lipid-based artificial membrane models have been developed in recent years and, indeed
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