Search Within
D8764
Applied Filters:
Keyword:'D8764'
Showing 1-30 of 48 results for "D8764" within Papers
Kaori Kimura-Kataoka et al.
Electrophoresis, 33(18), 2852-2858 (2012-09-29)
Five SNPs in the human DNase II gene have been reported to be associated with rheumatoid arthritis (RA). Genotype and haplotype analysis of 14 SNPs, nine SNPs of which reported in the NCBI dbSNP database in addition to these five
Lars Holmgren
Biochemical and biophysical research communications, 396(1), 147-151 (2010-05-25)
Horizontal or lateral gene transfer is an effective mechanism for the exchange of genetic information in bacteria allowing bacterial diversification and facilitating adaptation to new environments. Recent data demonstrate that DNA may also be transferred between somatic cells via the
Bingqi Zhang et al.
Acta biomaterialia, 7(4), 1580-1587 (2010-12-01)
Transfection efficiencies of non-viral gene delivery vectors commonly vary with cell type, owing to differences in proliferation rates and intracellular characteristics. Previous work demonstrated that the poly(diethylaminoethylmethacrylate) (PDEAEM)/Pluronic F127 pentablock copolymers exhibit transfection in vitro selectively in cancer cell lines
Yusuke Kitahara et al.
European journal of immunology, 40(9), 2590-2598 (2010-08-14)
The chromosomal DNA of apoptotic cells and the nuclear DNA expelled from erythroid precursors is cleaved by DNase II in lysosomes after the cells or nuclei are engulfed by macrophages. DNase II(-/-) embryos suffer from lethal anemia due to IFN-beta
Chloé Leprêtre et al.
Apoptosis : an international journal on programmed cell death, 18(9), 1048-1059 (2013-05-16)
Programmed cell death is an important factor in tissue homeostasis. Lot of work has been performed to characterize the caspase-dependent cell death. Caspase-independent cell death, although important in many physiological situations, is less investigated. In this work we show that
Takafumi Oka et al.
Nature, 485(7397), 251-255 (2012-04-27)
Heart failure is a leading cause of morbidity and mortality in industrialized countries. Although infection with microorganisms is not involved in the development of heart failure in most cases, inflammation has been implicated in the pathogenesis of heart failure. However
Kohki Kawane et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19432-19437 (2010-10-27)
DNase II digests the chromosomal DNA in macrophages after apoptotic cells and nuclei from erythroid precursors are engulfed. The DNase II-null mice develop a polyarthritis that resembles rheumatoid arthritis. Here, we showed that when bone marrow cells from the DNase
Dandan Liang et al.
Nature communications, 12(1), 287-287 (2021-01-14)
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the contraction of the heart in mammals. Though discovered over a century ago, the molecular and cellular features of the SAN that underpin its critical function in the heart are
M A Krasnorutskii et al.
Biochemistry. Biokhimiia, 76(9), 1065-1072 (2011-11-16)
Relative DNase, RNase (efficiency of hydrolysis of ribo- and deoxyribooligonucleotides (ON)), and phosphatase (removal of the ON 5' terminal phosphate) catalytic activities of antibodies (AB) obtained after rabbit immunization by DNA, DNase I, and DNase II were compared. It is
Barbara Messner et al.
Toxicology letters, 212(3), 268-275 (2012-06-09)
Cadmium is a highly toxic, carcinogenic, and atherogenic element. A central principle in many Cd-induced pathophysiologies is the induction of cell death. In past studies Cd was shown to cause apoptosis, necrosis, programmed necrosis, or autophagy. This study was conducted
Nobuyuki Kuramoto et al.
Journal of neuroscience research, 89(4), 552-561 (2011-02-04)
The organotin trimethyltin (TMT) is well known to cause neuronal damage in the central nervous system. To elucidate the mechanisms underlying the toxicity of TMT toward neurons, we prepared primary cultures of neurons from the neocortex of mouse embryos. A
Yanick J Crow
European journal of immunology, 40(9), 2376-2378 (2010-08-14)
DNase II is an endonuclease which plays a fundamental role in the degradation of DNA from both apoptotic cells, and nuclei extruded from red blood cells during erythropoiesis: important tasks, considering that everyday 10(8)-10(9) cells undergo apoptosis, and 10(11) red
Jeonghyun Ahn et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(47), 19386-19391 (2012-11-08)
Inflammatory autoimmune diseases such as systemic lupus erythematosus (SLE) and polyarthritis are characterized by chronic cytokine overproduction, suggesting that the stimulation of host innate immune responses, speculatively by persistent infection or self nucleic acids, plays a role in the manifestation
Andreas Zollner et al.
Journal of Crohn's & colitis, 15(1), 43-54 (2020-06-20)
Faecal biomarkers, particularly calprotectin [FCAL], have become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As FCAL is mainly produced by neutrophils, we hypothesised that faecal lipocalin-2 [FLCN2], also expressed by intestinal epithelial cells [IEC], could be beneficial
William Pendergrass et al.
Molecular vision, 17, 2672-2684 (2011-11-09)
To determine the differences between species in the retention of lens fiber cell nuclei and nuclear fragments in the aging lens cortex and the relationship of nuclear retention to lens opacity. For this purpose old human, monkey, dog, and rat
Roberta A Gottlieb et al.
Cell research, 22(11), 1518-1520 (2012-06-20)
The link between impaired autophagic flux (autophagus interruptus), damaged mitochondria, and myocardial inflammation has been further tightened with the recent paper by Oka and colleagues, in which failure to degrade mitochondrial DNA exacerbated myocardial inflammation in the context of pressure
Roman Vuerich et al.
NPJ Regenerative medicine, 8(1), 8-8 (2023-02-12)
Nonhealing wounds place a significant burden on both quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of nonhealing wounds, although their efficacy is limited by inadequate vascularization. The stromal vascular fraction
Hiroyuki Yoshida et al.
European journal of immunology, 41(2), 425-436 (2011-01-27)
Dying cells release genomic DNA into the surroundings where the DNA is first degraded to oligodeoxynucleotides, then to nucleotides, nucleosides and so on. Given that the unmethylated CpG dinucleotide (CpG motif), which is characteristic of bacterial DNA, is also contained
Kaja Breckwoldt et al.
Nature protocols, 12(6), 1177-1197 (2017-05-12)
Since the advent of the generation of human induced pluripotent stem cells (hiPSCs), numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and then subsequently assess their ability to recapitulate the properties of adult human cardiomyocytes. However, hiPSC-derived cardiomyocytes
Bernhard Texler et al.
Cellular and molecular gastroenterology and hepatology, 13(2), 383-404 (2021-10-09)
By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in ulcerative colitis many aspects concerning its mode of
Dusan Sokolovic et al.
Drug and chemical toxicology, 36(2), 141-148 (2012-03-06)
Accumulation of hydrophobic bile acids (BAs) during cholestasis plays an important role in apoptosis initiation as well as oxidative stress increase in liver cells. Ursodeoxycholic acid (UDCA) acts as a protector in BA-induced cell injury.The aim of the study was
The structure of PstI-repeats adjacent to the growth hormone gene and transcription of the family of PstI-repeats in various bovine organs
Akopian, K., et al.
Molecular Biology, 24, 775-780 (1990)
[Molecular mechanisms and physiological roles of DNA degradation].
Kohki Kawane
Seikagaku. The Journal of Japanese Biochemical Society, 81(9), 765-779 (2009-11-04)
Hanna Schierbeck et al.
Molecular medicine (Cambridge, Mass.), 17(9-10), 1039-1044 (2011-06-15)
High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB1 promotes inflammation. Experimental studies demonstrate HMGB1 to be a pathogenic factor in many inflammatory
K Nitta et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 114(2), 119-128 (1994-02-01)
Deoxyribonucleases from eggs and the liver of Xenopus laevis were partially purified by DEAE-cellulose and heparin-Sepharose affinity column chromatographies. The fractions having egg and liver DNase activities were eluted on high performance liquid chromatography through TSK gel G3000SW at the
Abigail Jarret et al.
Cell, 180(1), 50-63 (2020-01-11)
Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we show that the enteric nervous
Xi Liu et al.
PloS one, 7(8), e42725-e42725 (2012-08-24)
Innate immune responses against DNA are essential to counter both pathogen infections and tissue damages. Mammalian EYAs were recently shown to play a role in regulating the innate immune responses against DNA. Here, we demonstrate that the unique Drosophila eya
Ubaldo Gioia et al.
Nature cell biology, 25(4), 550-564 (2023-03-10)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was reported to alter several cellular pathways, its impact on DNA integrity and the mechanisms involved remain unknown. Here
George C Linderman et al.
Nature communications, 13(1), 192-192 (2022-01-13)
A key challenge in analyzing single cell RNA-sequencing data is the large number of false zeros, where genes actually expressed in a given cell are incorrectly measured as unexpressed. We present a method based on low-rank matrix approximation which imputes
Therese Ostberg et al.
Arthritis and rheumatism, 62(10), 2963-2972 (2010-06-10)
High mobility group box chromosomal protein 1 (HMGB-1) is a DNA binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB-1 promotes inflammation. Clinical and experimental studies demonstrate that HMGB-1 is a pathogenic factor
Page 1 of 2