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Showing 1-30 of 48 results for "D9753" within Papers
W A Divers et al.
American journal of obstetrics and gynecology, 141(6), 608-610 (1981-11-15)
Simultaneous determinations of amniotic fluid levels of the catecholamines dopamine (DA), norepinephrine (NE), and epinephrine (E), and the intraneuronal metabolites of DA, 3,4-dihydroxyphenylacetic acid (DOPAC) and NE, 3,4-dihydroxyphenylglycol (DOPEG), were made, by radioenzymatic assay, in pregnancies resulting in growth-retarded (n
Leslie R Whitaker et al.
Neuron, 77(2), 335-345 (2013-01-29)
Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life, particularly during adolescence, increase addiction vulnerability. Social isolation in rodents has been used extensively to model the effects of deficient social experience, yet its impact on
J D Elsworth et al.
Journal of neurochemistry, 41(3), 786-793 (1983-09-01)
A gas chromatographic-mass spectrometric assay, which allowed simultaneous measurement of 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylglycol (DHPG), was used to show that the concentration of MHPG in primate CNS far exceeded that of DHPG and that both metabolites were mainly in the
J L Izzo et al.
Life sciences, 33(5), 483-488 (1983-08-01)
An adaptation of the single-isotope radioenzymatic catecholamine assay technique allows simultaneous quantitation of free dihydroxyphenylglycol (DHPG), dihydroxymandelic acid (DOMA), and dihydroxyphenylacetic acid (DOPAC) in small volumes of plasma. Incubation of sample with catechol-O-methyltransferase and S-adenosylmethionine is followed by acidic extractions
Lili Sun et al.
PloS one, 7(3), e32503-e32503 (2012-03-24)
The activation of group I metabotropic glutamate receptor (group I mGlus) has been shown to produce neuroprotective or neurotoxic effects. In this study, we investigated the effects of N-acetylcysteine (NAC), a precursor of the antioxidant glutathione, on group I mGlus
Giulia Quattrocolo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5486-5498 (2013-03-29)
Cajal-Retzius cells are a class of neurons believed to play critical roles during cortical development. However, their network computational functions remain poorly understood. Although work in the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclusively
Catherine M Kopil et al.
Journal of neurochemistry, 123(1), 147-158 (2012-07-06)
Disruption of neuronal Ca(2+) homeostasis plays a well-established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that proteolysis of the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), a Ca(2+) release channel on the endoplasmic reticulum, generates
Giuseppe Sciamanna et al.
Neurobiology of disease, 47(3), 416-427 (2012-05-15)
DYT1 dystonia, a common and severe primary dystonia, is caused by a 3-bp deletion in TOR1A which encodes torsinA, a protein found in the endoplasmic reticulum. Several cellular functions are altered by the mutant protein, but at a systems level
Devesh Mishra et al.
Alcoholism, clinical and experimental research, 36(12), 2117-2125 (2012-05-04)
Long-term changes in the efficacy of glutamatergic synaptic transmission in reward-related brain regions such as the nucleus accumbens (NAc) are proposed to contribute to neuroadaptations that lead to drug addiction. Although alcohol is a widely used addictive substance, the cellular
Youngsoo Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11414-11423 (2012-08-17)
Canonical transient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-coupled receptors (GPCRs), activated via phospholipase C-diacylglycerol signaling. In cerebellar Purkinje cells, TRPC3 channels cause the metabotropic glutamate receptor (mGluR)-mediated slow EPSC (sEPSC). TRPC3 channels also provide negative feedback
Juan R Martinez-Galan et al.
Journal of neuroscience research, 90(10), 1913-1923 (2012-06-21)
Group I metabotropic glutamate receptors (mGluRs) are linked to intracellular Ca(2+) signalling and play important roles related to synaptic plasticity and development. In neurons from the central nucleus of the inferior colliculus (CIC), the activation of these receptors evokes large
Graeme Eisenhofer et al.
Pharmacological reviews, 56(3), 331-349 (2004-08-20)
This article provides an update about catecholamine metabolism, with emphasis on correcting common misconceptions relevant to catecholamine systems in health and disease. Importantly, most metabolism of catecholamines takes place within the same cells where the amines are synthesized. This mainly
Ozlem Bozdagi et al.
PloS one, 7(8), e42422-e42422 (2012-08-18)
Copy number variation (CNV) at the 15q11.2 region, which includes a gene that codes for CYFIP1 (cytoplasmic FMR1 interacting protein 1), has been implicated in autism, intellectual disability and additional neuropsychiatric phenotypes. In the current study we studied the function
Huizhi Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(38), 15022-15031 (2013-09-21)
Endocannabinoids play essential roles in synaptic plasticity; thus, their dysfunction often causes impairments in memory or cognition. However, it is not well understood whether deficits in the endocannabinoid system account for the cognitive symptoms of schizophrenia. Here, we show that
P E Graham et al.
Annals of clinical biochemistry, 30 ( Pt 2), 129-134 (1993-03-01)
There is a diversity of advice in the literature as to which biochemical assays are best suited to the investigation of patients with a suspected phaeochromocytoma. The challenge for the clinical laboratory is to select those assays which detect all
W A Divers et al.
American journal of obstetrics and gynecology, 141(6), 625-628 (1981-11-15)
To assess the effect of maternal smoking on fetal adrenergic activity, simultaneous measurements in amniotic fluid of the parent catecholamines, dopamine (DA), norepinephrine (NE), and epinephrine (E), as well as the specific intraneuronal deaminated metabolites of DA, 3,4-dihydroxyphenylacetic acid (DOPAC)
Aditi Bhattacharya et al.
Neuron, 76(2), 325-337 (2012-10-23)
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream
Andrius Baskys et al.
Annals of the New York Academy of Sciences, 1053, 55-73 (2005-09-24)
Stroke neuroprotection trials suggest that pharmacological manipulations of a single neuroprotective mechanism are generally ineffective and that new approaches, possibly involving simultaneous manipulations of multiple mechanisms, need to be sought. To identify optimal components for such a multipronged approach, we
Saurabh Pandey et al.
Journal of neurochemistry, 131(5), 602-614 (2014-08-13)
Trafficking of G protein-coupled receptors plays a crucial role in controlling the precise signalling of the receptor as well as its proper regulation. Metabotropic glutamate receptor 1 (mGluR1), a G protein-coupled receptor, is a member of the group I mGluR
Ying-Lin Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9013-9020 (2013-05-24)
The translation of dendritic microtubule-associated protein 1B (MAP1B) is exaggerated upon group I mGluR activation leading to AMPA receptor (AMPAR) endocytosis and consequent long-term depression. However, the mechanisms of regulation of MAP1B protein synthesis in the mature dendrites remain unclear.
David S Goldstein et al.
Brain : a journal of neurology, 135(Pt 6), 1900-1913 (2012-03-28)
Central catecholamine deficiency characterizes α-synucleinopathies such as Parkinson's disease. We hypothesized that cerebrospinal fluid levels of neuronal metabolites of catecholamines provide neurochemical biomarkers of these disorders. To test this hypothesis we measured cerebrospinal fluid levels of catechols including dopamine, norepinephrine
Osnat Ben-Shahar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 495-506a-495-506a (2013-01-11)
Anomalies in prefrontal cortex (PFC) function are posited to underpin difficulties in learning to suppress drug-seeking behavior during abstinence. Because group 1 metabotropic glutamate receptors (mGluRs) regulate drug-related learning, we assayed the consequences of extended access to intravenous cocaine (6
Wei Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5867-5877 (2013-03-29)
Although the contribution of postsynaptic mechanisms to long-term synaptic plasticity has been studied extensively, understanding the contribution of presynaptic modifications to this process lags behind, primarily because of a lack of techniques with which to directly and quantifiably measure neurotransmitter
Fumiko Yamaki et al.
European journal of pharmacology, 877, 173079-173079 (2020-04-05)
Certain catecholamine metabolites exert significant pharmacological effects. Herein, we evaluated the pharmacological activities of catecholamine metabolites in the rat thoracic aorta, prostate, and spleen to determine whether these metabolites affect the contractile functions of smooth muscle tissue via direct action
Maiko Machida et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 249-254 (2005-11-23)
The clinical importance of simultaneous analysis of 3,4-dihydroxyphenylglycol with other human plasma catecholamines has been investigated to better understand the sympathetic nervous system. However, previous reports have had analytical difficulties with both resolution and extraction. The current study uses a
Adrianne R Wilson-Poe et al.
Neuropharmacology, 66, 348-354 (2012-07-10)
Metabotropic glutamate (mGlu) receptors modulate pain from within the midbrain periaqueductal grey (PAG). In the present study, the postsynaptic mGlu receptor mediated effects on rat PAG neurons were examined using whole-cell patch-clamp recordings in brain slices. The selective group I
Steven R Young et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2526-2540 (2013-02-09)
Plastic changes in cortical activities induced by group I metabotropic glutamate receptor (mGluR) stimulation include epileptogenesis, expressed in vitro as the conversion of normal neuronal activity to persistent, prolonged synchronized (ictal) discharges. At present, the mechanism that maintains group I
Guillermo Rodríguez-Gutiérrez et al.
Molecular nutrition & food research, 56(7), 1137-1147 (2012-06-01)
Olive products are rich in phenolic compounds, which are natural antioxidants in vitro. We tested the in vivo effects of alperujo, an olive production by-product, as well as hydroxytyrosol and 3,4-dihydroxyphenylglycol (DHPG) isolated from alperujo, on indices and pathways of
H Lôo et al.
L'Encephale, 9(4), 297-316 (1983-01-01)
The plasmatic levels of free, sulfoconjugated and total dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of noradrenaline, have been measured in thirty DSM3 major depressive inpatients and in thirty healthy controls matched for sex and age. DOPEG levels have been measured
C Julien et al.
Clinical chemistry, 34(5), 966-969 (1988-05-01)
We describe the conjoint measurement in urine of the alcoholic catecholamine metabolites 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG). The method involves extraction with ethyl acetate and back-extraction into acetic acid (MHPG), followed by adsorption onto alumina (DHPG). The separation is performed
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