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Showing 1-30 of 494 results for "DUO92009" within Papers
Takashi Nakakuki et al.
Cell, 141(5), 884-896 (2010-05-25)
Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG) determines distinct cell-fate decisions, although signals propagate through shared pathways. Using mathematical modeling and experimental approaches, we unravel how HRG and EGF generate distinct, all-or-none responses of the
Yin Yin Choo et al.
PloS one, 7(7), e41350-e41350 (2012-08-23)
Cullin E3 ligases are the largest family of ubiquitin ligases with diverse cellular functions. One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit ubiquitin ligase complex. Cullin binds the RING domain protein Rbx1/Rbx2
Nathalie Saint-Lu et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(4), 894-901 (2012-01-24)
Although von Willebrand factor (VWF) is a heavily glycosylated protein, its potential to associate with glycan-binding proteins is poorly investigated. Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3. Immunofluorescence analysis using Duolink proximity ligation assays revealed
Eva Martínez-Pinilla et al.
Molecular neurobiology, 56(8), 5900-5910 (2019-01-29)
Cannabinoid CB1 receptors (CB1R) and the GPR55 receptor are expressed in striatum and are potential targets in the therapy of Parkinson's disease (PD), one of the most prevalent neurodegenerative diseases in developed countries. The aim of this paper was to
Byung-Kwon Choi et al.
Cancer medicine, 1(1), 28-38 (2013-01-24)
Aberrant expression and activation of EGFR and ERBB2 (HER2) have been successfully targeted for cancer therapeutics. Recent evidence from both basic and clinical studies suggests that ERBB3 (HER3) serves as a key activator of downstream signaling through dimerization with other
Valerie Le Sage et al.
Virology, 502, 73-83 (2016-12-26)
Stress granules (SGs) are dynamic cytoplasmic aggregates of translationally silenced mRNAs that assemble in response to environmental stress. SGs appear to play an important role in antiviral innate immunity and many viruses have evolved to block or subvert SGs components
Alexander Brobeil et al.
Biomolecules, 7(3) (2017-07-30)
Protein-protein interactions play a pivotal role in normal cellular functions as well as in carcinogenesis. The protein-protein interactions form functional clusters during signal transduction. To elucidate the fine calibration of the protein-protein interactions of protein tyrosine phosphatase interacting protein 51
Lena Larsson et al.
Journal of periodontology, 82(9), 1376-1382 (2011-02-12)
Interleukin (IL)-10 is an important cytokine in immune regulation, and the -1087 IL-10 single nucleotide polymorphism (SNP) is associated with chronic periodontitis. The binding of the transcription factor Sp1 to the -1087 position in the IL-10 promoter upregulates IL-10 gene
Magdalena M Kordon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201801379R-fj201801379R (2018-09-28)
DNA lesions induce recruitment and accumulation of various repair factors, resulting in formation of discrete nuclear foci. Using superresolution fluorescence microscopy as well as live cell and quantitative imaging, we demonstrate that X-ray repair cross-complementing protein 1 (XRCC1), a key
Hadjer Miloudi et al.
Cellular signalling, 46, 76-82 (2018-03-05)
Primary mediastinal B-cell lymphoma (PMBL) is a distinct B-cell lymphoma subtype with unique clinicopathological and molecular features. PMBL cells are characterised by several genetic abnormalities that conduct to the constitutive activation of the Janus kinase 2/signal transducer and activator of
Elizabeth G Bromfield et al.
Molecular human reproduction, 23(2), 91-105 (2016-12-10)
Does oxidative stress compromise the protein expression of heat shock protein A2 (HSPA2) in the developing germ cells of the mouse testis? Oxidative stress leads to the modification of HSPA2 by the lipid aldehyde 4-hydroxynonenal (4HNE) and initiates its degradation
Ulrike Garscha et al.
Scientific reports, 7(1), 9398-9398 (2017-08-26)
Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Accordingly, dual FLAP/sEH inhibition might
Cesar A G Arrais et al.
Journal of dentistry, 36(6), 418-426 (2008-04-09)
To evaluate the effects of different curing conditions on the degree of conversion (DC) of dual-cured cementing systems [combination of bonding agent (BA) and resin cement (RC)] using infrared spectroscopy. Four fourth generation products [Scotchbond Multipurpose Plus/RelyX (3M ESPE), Optibond/Nexus
Mahmoud Soliman et al.
Journal of virology, 92(24) (2018-10-05)
Sapovirus, an important cause of acute gastroenteritis in humans and animals, travels from the early to the late endosomes and requires late endosomal acidification for viral uncoating. However, the signaling pathways responsible for these viral entry processes remain unknown. Here
Michael Lie-A-Ling et al.
Development (Cambridge, England), 145(5) (2018-03-14)
During ontogeny, hematopoietic stem and progenitor cells arise from hemogenic endothelium through an endothelial-to-hematopoietic transition that is strictly dependent on the transcription factor RUNX1. Although it is well established that RUNX1 is essential for the onset of hematopoiesis, little is
Yuichiro Semba et al.
Nucleic acids research, 45(15), 8758-8772 (2017-05-27)
Chromatin reorganization is necessary for pluripotent stem cells, including embryonic stem cells (ESCs), to acquire lineage potential. However, it remains unclear how ESCs maintain their characteristic chromatin state for appropriate gene expression upon differentiation. Here, we demonstrate that chromodomain helicase
Alexander Brobeil et al.
Biomolecules, 2(1), 122-142 (2012-01-01)
Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the
Aaron Provence et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 131-144 (2017-11-01)
Voltage-gated KV7 channels (KV7.1 to KV7.5) are important regulators of the cell membrane potential in detrusor smooth muscle (DSM) of the urinary bladder. This study sought to further the current knowledge of KV7 channel function at the molecular, cellular, and
Cecilia Boreström et al.
The Journal of general virology, 93(Pt 5), 1065-1075 (2012-02-04)
The Epstein-Barr virus (EBV) C promoter (Cp) regulates several genes required for B-cell proliferation in latent EBV infection. The family of repeats (FR) region of the latent origin of plasmid replication (oriP) functions as an Epstein-Barr nuclear antigen 1 (EBNA1)-dependent
Seo-Young An et al.
Imaging science in dentistry, 48(2), 97-101 (2018-07-03)
This study evaluated the radiopacity of contemporary luting cements using conventional and digital radiography. Disc specimens (N=24, n=6 per group, ø7 mm×1 mm) were prepared using 4 resin-based luting cements (Duolink, Multilink N, Panavia F 2.0, and U-cem). The specimens
Karl-Johan Leuchowius et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 75(10), 833-839 (2009-08-04)
Interactions between members of the epidermal growth factor receptor (EGFR) family mediates cellular responses to ligand stimulation. Measurement of these interactions could provide important information and may prove useful as prognostic markers in malignancy. Therefore, to develop methods to study
M H Rubo et al.
The International journal of prosthodontics, 11(1), 70-74 (1998-05-20)
The objective of this study was to determine radiopacity values of a group of resin-based cements and to compare them to those of enamel and dentin. Three specimens 2.5 mm thick were prepared from each of 18 cements (nine chemical-cured
Rémi Lasserre et al.
The Journal of cell biology, 195(5), 839-853 (2011-11-23)
Antigen recognition within immunological synapses triggers and sustains T cell activation by nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors. Dissipation of these microclusters results in signal termination, but how this process is regulated is unclear.
Kai-Hui Chan et al.
American journal of translational research, 9(3), 1173-1182 (2017-04-08)
Although signal transduction of transforming growth factor-betas (TGF-βs) is well characterized in individual cell types, data about TGF-β signaling in a cellular context is still scarce. In this study, we used ex vivo tubule cultures from adult rat testis to
Iria Carballo-Carbajal et al.
Nature communications, 10(1), 973-973 (2019-03-09)
In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains
M Bobrich et al.
International journal of obesity (2005), 35(11), 1385-1394 (2011-01-27)
We investigated the expression of protein tyrosine phosphatase-interacting protein 51 (PTPIP51) and its interaction with protein tyrosine phosphatase 1B (PTP1B) and 14-3-3β in mice exhibiting insulin resistance and obesity. A total of 20 mice were included in the study. Eight
Hala Elnakat Thomas et al.
Cell reports, 24(9), 2404-2417 (2018-08-30)
Cells adapt to nutrient and energy deprivation by inducing autophagy, which is regulated by the mammalian target of rapamycin (mTOR) and AMP-activated protein kinases (AMPKs). We found that cell metabolism significantly influences the ability to induce autophagy, with mitochondrial complex
Eya Wolfson et al.
Cell death & disease, 9(2), 47-47 (2018-01-21)
ErbB2, a member of the ErbB family of receptor tyrosine kinases, is an essential player in the cell's growth and proliferation signaling pathways. Amplification or overexpression of ErbB2 is observed in ∼30% of breast cancer patients, and often drives cellular
Karen Frudd et al.
Nature communications, 9(1), 95-95 (2018-01-10)
Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective macromolecules and organelles, as well as providing bioenergetic intermediates during hypoxia and nutrient deprivation. Here we report a thiol-dependent process that may account for impaired autophagy during aging. This
Aaron Gajadhar et al.
BioTechniques, 48(2), 145-152 (2010-04-03)
The development of small molecule and antibody inhibitors targeting the interaction of receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR), is of high pharmacological and biological interest. Unfortunately, conventional biochemical techniques using cell or tissue lysates and
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