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Showing 1-16 of 16 results for "E2156" within Papers
Kevin Seekell et al.
Methods (San Diego, Calif.), 56(2), 310-316 (2011-09-14)
Noble metal nanoparticles hold great potential as optical contrast agents due to a unique feature, known as the plasmon resonance, which produces enhanced scattering and absorption at specific frequencies. The plasmon resonance also provides a spectral tunability that is not
Melissa C Skala et al.
Methods in molecular biology (Clifton, N.J.), 1026, 85-92 (2013-06-12)
Optical coherence tomography (OCT) is a three-dimensional optical imaging technique that has been successfully implemented in ophthalmology for imaging the human retina, and in studying animal models of disease. OCT can nondestructively visualize structural features in tissue at cellular-level resolution
Elena Lesma et al.
Journal of cellular and molecular medicine, 18(5), 766-779 (2014-03-13)
Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 or TSC2 genes. Lymphangioleiomyomatosis (LAM) can be sporadic or associated with TSC and is characterized by widespread pulmonary proliferation of abnormal α-smooth muscle (ASM)-like cells. We investigated the features of
Toni M Brand et al.
Discovery medicine, 12(66), 419-432 (2011-12-01)
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through various pathways ultimately resulting in cellular proliferation, survival, angiogenesis, invasion, and metastasis. Aberrant
Review of epidermal growth factor receptor biology
Herbst R S, et al.
International Journal of Radiation Oncology, Biology, Physics, 59(2), S21-S26 (2004)
Sangheon Han et al.
ACS nano, 15(6), 9495-9508 (2021-05-21)
Nanoparticles with ultrasmall sizes (less than 10 nm) offer many advantages in biomedical applications compared to their bigger counterparts, including better intratumoral distribution, improved pharmacokinetics (PK), and efficient body clearance. When functionalized with a biocompatible coating and a target-specific antibody
Matthew J Crow et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(1), 57-65 (2010-12-25)
Fluorescence-based flow cytometry measures multiple cellular characteristics, including levels of receptor expression, by assessing the fluorescence intensity from a population of cells whose cell surface receptors are bound by a fluorescently labeled antibody or ligand for that receptor. Functionalized noble
Molecular imaging of epidermal growth factor receptor in live cells with refractive index sensitivity using dark-field microspectroscopy and immunotargeted nanoparticles
Curry A C, et al.
Journal of Biomedical Optics, 13(1), 014022-014022 (2008)
Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles
Crow M J, et al.
American Journal of Respiratory Cell and Molecular Biology, 192(4), 1021-1028 (2009)
Melissa C Skala et al.
Nano letters, 8(10), 3461-3467 (2008-09-05)
Molecular imaging is a powerful tool for investigating disease processes and potential therapies in both in vivo and in vitro systems. However, high resolution molecular imaging has been limited to relatively shallow penetration depths that can be accessed with microscopy.
Nicole E Willmarth et al.
The Journal of biological chemistry, 281(49), 37728-37737 (2006-10-13)
Amphiregulin (AR) autocrine loops have been associated with several types of cancer. We demonstrate that SUM149 breast cancer cells have a self-sustaining AR autocrine loop. SUM149 cells are epidermal growth factor (EGF)-independent for growth, and they overexpress AR mRNA, AR
Will J Eldridge et al.
Biomedical optics express, 5(8), 2517-2525 (2014-08-20)
We present a fast, wide-field holography system for detecting photothermally excited gold nanospheres with combined quantitative phase imaging. An interferometric photothermal optical lock-in approach (POLI) is shown to improve SNR for detecting nanoparticles (NPs) on multiple substrates, including a monolayer
Gustavo Bodelón et al.
Small (Weinheim an der Bergstrasse, Germany), 11(33), 4149-4157 (2015-05-06)
Detection technologies employing optically encoded particles have gained much interest toward clinical diagnostics and drug discovery, but the portfolio of available systems is still limited. The fabrication and characterization of highly stable surface-enhanced resonance Raman scattering (SERRS)-encoded colloids for the
Matthew J Crow et al.
AJR. American journal of roentgenology, 192(4), 1021-1028 (2009-03-24)
The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. EGFR expression was quantified using both imaging methods in four cell lines: A431 human
Kevin Seekell et al.
Biomedical optics express, 4(11), 2284-2295 (2013-12-04)
Effective treatment of patients with malignant brain tumors requires surgical resection of a high percentage of the bulk tumor. Surgeons require a method that enables delineation of tumor margins, which are not visually distinct by eye. In this study, the
Shinji Kuroda et al.
International journal of nanomedicine, 9, 3825-3839 (2014-08-22)
We have previously demonstrated the epidermal growth factor receptor (EGFR)-targeted hybrid plasmonic magnetic nanoparticles (225-NP) produce a therapeutic effect in human lung cancer cell lines in vitro. In the present study, we investigated the molecular mechanism of 225-NP-mediated antitumor activity
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