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Showing 1-30 of 499 results for "E2758" within Papers
Si-Jia Zhong et al.
International journal of medical sciences, 17(8), 1048-1055 (2020-05-16)
Ginsenoside Rg1 is the main active ingredient of Panax ginseng with the activity of neuroprotective, antioxidant and strengthening the immune system. Therefore, we hypothesized that Rg1 may afford anti-aging effects although the mechanism remains to be elucidated. In this study
Deborah M Roll et al.
Journal of natural products, 72(11), 1944-1948 (2009-10-30)
Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5.
Zbynek Heger et al.
Neuro endocrinology letters, 34 Suppl 2, 123-129 (2013-12-24)
Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at very low concentrations have potential to cause xenoestrogenic effects. During exposure of excessive amounts of estradiols may be produced
Jenny Clarkson
Frontiers in neuroendocrinology, 34(2), 120-131 (2013-03-19)
The activation of the gonadotropin-releasing hormone (GnRH) neurons from a state of relative quiescence is critical for initiating puberty in mammals. Kisspeptin and its G-protein coupled receptor Gpr54 are essential for puberty, with disruption to either resulting in failed puberty
Is men's health just a single letter?
Bradley D Anawalt
The Journal of clinical endocrinology and metabolism, 99(1), 70-72 (2014-01-05)
Lina Wang et al.
Surgery, 156(2), 243-252 (2014-06-25)
Studies from our group and others have indicated that paracrine function is one of major mechanisms underlying stem cell-mediated cardioprotection. To improve therapeutic efficacy of cardiac stem cells (CSCs), modification of CSCs to enhance their paracrine actions is of great
Sabine Möcklinghoff et al.
Journal of medicinal chemistry, 54(7), 2005-2011 (2011-03-09)
A library of small tetrahydroisoquinoline ligands, previously identified via structure- and chemistry-based hierarchical organization of library scaffolds in tree-like arrangements, has been generated as novel estrogen receptor agonistic fragments via traditional medicinal chemistry exploration. The approach described has allowed for
Muath Q Al-Ghadi et al.
Saudi journal of biological sciences, 27(9), 2280-2286 (2020-09-05)
Although, it has been success in the generation of animal clones from somatic cells in various animal species, the information related to nuclear reprogramming of cloned embryos is found to be limited. This study aims to compares the effect of
Yogeshwar Makanji et al.
American journal of physiology. Endocrinology and metabolism, 306(8), E893-E903 (2014-02-27)
Oxygen tension is critical for follicle growth and metabolism, especially for early-stage follicles, where vascularity is limited. Its role and underlying mechanism in the in vitro activation and maturation of immature to ovulatory follicles is largely unknown. In this study
Richard Chesworth et al.
Bioorganic & medicinal chemistry letters, 15(24), 5562-5566 (2005-10-13)
A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.
Marjoke Heneweer et al.
Toxicological sciences : an official journal of the Society of Toxicology, 83(2), 257-263 (2004-11-05)
Approximately 60% of all breast tumors are estrogen-responsive and chemicals that show estrogenic or anti-estrogenic properties are able to interact with breast tumor growth. In a breast tumor, adipose stromal cells (fibroblasts) surrounding the epithelial tumor contain the aromatase enzyme
Ting Lian et al.
Toxicology research, 9(3), 173-181 (2020-07-17)
Chlordecone (CD) is one of the common persistent organic pollutants in nature and has a profound impact on the environment and on public health. Accumulating evidence has demonstrated that neonatal exposure of CD influences adult physiology and behavior due to
Christopher T Smith et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5468-5476 (2014-04-18)
A variety of evidence suggests that, among humans, the individual tendency to choose immediate rewards ("Now") over larger, delayed rewards ("Later"), or Now bias, varies with frontal dopamine (DA) levels. As cyclic elevations in estradiol (E+) modulate other frontal DA-dependent
Hong-Wen Yuan et al.
Zhen ci yan jiu = Acupuncture research, 38(2), 112-117 (2013-07-04)
To observe the influence of electroacupuncture (EA) stimulation of "Hegu" (LI 4) and "Sanyinjiao"(SP 6; a classical delivery-facilitating acupoint recipe) at different parameters on endocrine hormone levels of late-stage pregnant rats, so as to find the better stimulation parameters for
Yu Xiong et al.
Journal of medicinal chemistry, 50(14), 3340-3353 (2007-06-19)
To improve the specificity and potency of estrogen replacement therapy therapeutics while also minimizing the side effects such as bone resorption and thickening of the uterine wall, a series of novel estrogen-derived conjugates estradiol-3-RGD, estradiol-17-RGD, and estrone-3-RGD peptides have been
Pablo I F Inserra et al.
The Journal of steroid biochemistry and molecular biology, 200, 105627-105627 (2020-02-20)
The South American plains vizcacha, Lagostomus maximus, is the only mammal described so far that shows expression of estrogen receptors (ERs) and progesterone receptors (PRs) in gonadotropin-releasing hormone (GnRH) neurons. This animal therefore constitutes an exceptional model for the study
Alesha B Castillo et al.
American journal of physiology. Endocrinology and metabolism, 306(8), E937-E944 (2014-03-13)
Mechanical loading is an important regulator in skeletal growth, maintenance, and aging. Estrogen receptors have a regulatory role in mechanically induced bone adaptation. Estrogen receptor-α (ERα) is known to enhance load-induced bone formation, whereas ERβ negatively regulates this process. We
Qiang Hong et al.
Protein & cell, 10(5), 347-364 (2018-12-28)
Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9. sox3 knockout led to follicle development retardation
Simone Kühnle et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8888-8893 (2013-05-15)
Inactivation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with development of the Angelman syndrome. Recently, it was reported that in mice, loss of E6AP expression results in increased levels of the
Cristina Cruz et al.
eLife, 7 (2018-10-03)
Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan
Shelley S Tworoger et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(28), 3111-3117 (2014-08-20)
Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG)
Franziska Herster et al.
Nature communications, 11(1), 105-105 (2020-01-09)
Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. However, the source of
Ahmed Kamal et al.
Bioorganic & medicinal chemistry, 19(8), 2565-2581 (2011-04-05)
A series of new estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (E(2)-PBD) conjugates (3a-f, 4a-f and 5a-f) with different linker architectures including a triazole moiety have been designed and synthesized. All the 18 compounds have been evaluated for their anticancer activity and it is
Sara Balbuena-Pecino et al.
International journal of molecular sciences, 21(16) (2020-08-23)
Soybeans are one of the most used alternative dietary ingredients in aquafeeds. However, they contain phytoestrogens like genistein (GE), which can have an impact on fish metabolism and health. This study aimed to investigate the in vitro and in vivo
Kaberi Acharia et al.
Indian journal of experimental biology, 52(5), 538-541 (2014-05-24)
In the present study, the female Clarias batrachus, held under long photoperiod (13L:11D), were exposed to high water temperature either constantly (24 h) and/or in form of thermopulse of 6 h and 12 h durations, separately, at different times of
Mark A Tarnopolsky
Medicine and science in sports and exercise, 40(4), 648-654 (2008-03-05)
Women oxidize more lipid and less carbohydrate and protein compared with men during endurance exercise. The increase in fat oxidation is associated with higher intramyocellular lipid content and use as well as greater adipocyte lipolysis. Glucose rates of appearance and
E Nasatzky et al.
Connective tissue research, 30(4), 277-294 (1994-01-01)
Recently, sex hormones were shown to stimulate chondrocyte differentiation and matrix protein synthesis in vitro in a sex-specific and maturation-dependent manner. The aim of the present study was to determine whether cytosolic receptors in these cells would specifically bind 17
Eugen Dhimolea et al.
Cancer cell, 39(2), 240-256 (2021-01-09)
Treatment-persistent residual tumors impede curative cancer therapy. To understand this cancer cell state we generated models of treatment persistence that simulate the residual tumors. We observe that treatment-persistent tumor cells in organoids, xenografts, and cancer patients adopt a distinct and
Arunoday Bhan et al.
Journal of molecular biology, 426(20), 3426-3441 (2014-08-05)
Enhancer of Zeste homolog 2 (EZH2), a methyltransferase specific to histone 3 lysine 27, is a critical player in gene silencing and is overexpressed in breast cancer. Our studies demonstrate that EZH2 is transcriptionally induced by estradiol in cultured breast
Fengxia Wu et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 43-51 (2014-06-30)
We studied the effects of endocrine disrupting compounds nonylphenol (NP) and letrozole (LE) on the male goldfish Carassius aumtus. Exposure to NP (20 μg l(-1)) alone caused a significant up-regulation in the expression of aromatase, estrogen receptors and vitellogenin (VTG)
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