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Showing 1-30 of 499 results for "E2758" within Papers
Nathalia Moraes de Vasconcelos et al.
Cell reports, 32(4), 107959-107959 (2020-07-30)
Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death signaling during pyroptosis is fragmented.
Michael E Jones et al.
American journal of epidemiology, 179(9), 1128-1133 (2014-04-02)
Prospective cohort studies examining sex hormones in relation to cancer risk have generally collected blood samples at 1 time point, with an assumption that hormone levels measured in these samples will be reliable markers of true levels at other times.
Ulrik Engelsöy et al.
Frontiers in microbiology, 12, 682626-682626 (2021-08-07)
Uropathogenic Escherichia coli (UPEC) is the most common bacteria to cause urinary tract infection (UTI). Postmenopausal women have an increased risk of recurrent UTI. This is partly explained by estrogenic effects on host defenses against UTI. Current research is mostly
Vinit G Karur et al.
Blood, 108(5), 1524-1532 (2006-05-18)
Lyn kinase is known to modulate the formation and function of B cells, monocytes, and mast cells. However, Lyn-/- mice also develop erythrosplenomegaly, and cases for both negative and positive erythropoietic actions of Lyn recently have been outlined. In phenylhydrazine-treated
Raul Zavaliev et al.
Cell, 182(5), 1093-1108 (2020-08-19)
In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict cell death remain unclear.
Baojian Xue et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H191-H198 (2014-05-27)
This study investigated sex differences in the sensitization of angiotensin (ANG) II-induced hypertension and the role of central estrogen and ANG-(1-7) in this process. Male and female rats were implanted for telemetered blood pressure (BP) recording. A subcutaneous subpressor dose
Shoudong Guo et al.
Biochimica et biophysica acta, 1841(6), 836-846 (2014-03-08)
Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 108 healthy participants were
Qi Li et al.
Reproduction (Cambridge, England), 160(4), 511-519 (2020-07-23)
Endometriosis (EMs) is an estrogen (E2)-dependent inflammatory disorder. Although EMs is considered a benign disease, it presents with malignant characteristics, such as migration and invasion. An increasing number of studies have shown that aberrantly expressed circular RNAs (circRNAs) play an
Takamitsu Onitsuka et al.
Anticancer research, 31(3), 855-860 (2011-04-19)
Positive expression of estrogen receptor (ER) beta is correlated with a favorable prognosis for patients with epidermal growth factor receptor (EGFR) mutations and predicts a good clinical outcome for patients with lung cancer after treatment with an EGFR-tyrosine kinase inhibitor
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives
Gonadal steroids and body composition, strength, and sexual function in men.
Joel S Finkelstein et al.
The New England journal of medicine, 369(25), 2457-2457 (2013-12-20)
L N Olsen et al.
The Journal of physiology, 598(22), 5149-5164 (2020-09-24)
The risk of cardiovascular disease and associated skeletal muscle microvascular rarefaction is enhanced in women after menopause, yet knowledge about the angiogenic potential in ageing women is generally sparse. Aged healthy and sedentary women were found to present a markedly
Simone Ummarino et al.
Cells, 10(11) (2021-11-28)
Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and drive cells towards malignant transformation. Here
Joel S Finkelstein et al.
The New England journal of medicine, 369(11), 1011-1022 (2013-09-13)
Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations. We provided 198 healthy men 20 to 50 years of age with
Sandra Haider et al.
Endocrinology, 160(10), 2282-2297 (2019-07-11)
The human endometrium is the inner lining of the uterus consisting of stromal and epithelial (secretory and ciliated) cells. It undergoes a hormonally regulated monthly cycle of growth, differentiation, and desquamation. However, how these cyclic changes control the balance between
Lin Zhang et al.
Frontiers in cardiovascular medicine, 8, 679240-679240 (2021-07-06)
The incidence of dysfunctional vasomotor diseases has mostly occurred in postmenopausal women but not in premenopausal women. Hence, this study sought to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function. Also, attempts were made to utilize
Pin-Yao Huang et al.
Journal of experimental botany, 70(3), 1033-1047 (2018-11-22)
Recognition of microbe-associated molecular patterns (MAMPs) derived from invading pathogens by plant pattern recognition receptors (PRRs) initiates a subset of defense responses known as pattern-triggered immunity (PTI). Transcription factors (TFs) orchestrate the onset of PTI through complex signaling networks. Here
Laura Ballester et al.
Fertility and sterility, 102(6), 1762-1768 (2014-09-23)
To determine optimal conditions for the inclusion of oviductal fluid (OF) in IVF protocols. Experimental prospective study. Mammalian reproduction research laboratory. Oviducts and ovaries from porcine females were collected at a slaughterhouse. A total of 30 oviducts and 1,285 oocytes
Senlin Xiao et al.
Molecular plant, 13(9), 1270-1283 (2020-07-07)
Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility (CMS). Using yeast one-hybrid screening, we identified a transcription factor, ZmDREB1.7, that is highly expressed in sterile microspores at the large vacuole stage
Thomas Wiglenda et al.
Journal of medicinal chemistry, 48(20), 6516-6521 (2005-09-30)
The 1H-imidazoles 7a-e were synthesized and tested for biological activity in vitro. The results pointed to a clear structure-activity relationship. The introduction of an ethyl chain at C5 of the 1,2,4-tris(4-hydroxyphenyl)-1H-imidazole 7a caused hormonal activity in estrogen receptor positive MCF-7-2a
Qinghai Meng et al.
Biochemical pharmacology, 180, 114134-114134 (2020-07-07)
Decreases in estrogen secretion and estrogen receptor function lead to an increase in the incidence of dyslipidemia and cardiovascular disease (CVD) in postmenopausal women. We previously reported that β-estradiol has a significant regulatory effect on lipids in ApoE-/- mice with
Karen A Dunphy et al.
Journal of mammary gland biology and neoplasia, 25(1), 51-68 (2020-03-11)
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as rodent models
Andreas Natsch et al.
Toxicology reports, 8, 1002-1007 (2021-08-20)
Benzyl salicylate (BS) is a natural ingredient of essential oils and a widely used fragrance chemical. A number of in vitro screening studies have evaluated the estrogenic potential of BS with ambiguous results. Lack of dose-response information for the positive
Christine Cadot et al.
Bioorganic & medicinal chemistry, 15(2), 714-726 (2006-11-18)
A series of estrone and estradiol derivatives having an N-butyl,methyl heptanamide side chain at C6-position were synthesized, tested as inhibitors of type 1 17beta-HSD and assessed for their possible estrogenic activity. A better type 1 17beta-HSD inhibition was obtained for
Seiro Satohisa et al.
Endocrinology, 155(8), 3005-3016 (2014-06-01)
Adduction of a nitric oxide (NO) moiety (NO(•)) to cysteines termed as S-nitrosylation (SNO) has emerged as a crucial mechanism for NO signaling crucial for mediating the vascular effects of estrogens. Mitochondrion is a known vascular risk factor; however, the
Pardes Habib et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Acute ischemic stroke (AIS) is a devastating neurological condition with a lack of neuroprotective therapeutic options, despite the reperfusion modalities thrombolysis and thrombectomy. Post-ischemic brain damage is aggravated by an excessive inflammatory cascade involving the activation and regulation of the
L B Tankó et al.
Journal of internal medicine, 258(6), 544-553 (2005-11-30)
To investigate how variation in the dose of the progestogen influence the impact of 17beta-oestradiol plus drospirenone (DRSP) treatment on adipose tissue and its secretor function with direct implications for atherogenic metabolites. Randomized, double-blind, placebo-controlled trial. Primary care, single study
Kathryn J Grive et al.
Developmental biology, 392(1), 42-51 (2014-05-20)
Primary ovarian insufficiency (POI) affects 1% of women under the age of 40 and is associated with premature ovarian follicle depletion. TAF4b deficiency in adult female mouse models results in hallmarks of POI including stereotyped gonadotropin alterations indicative of early
M Andrés Blanco et al.
Cell reports, 37(6), 109967-109967 (2021-11-11)
Stem and progenitor cells have the capacity to balance self-renewal and differentiation. Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated neutrophils every day under homeostatic conditions and can increase this output in response to stress or infection. At
Shigeo Hayashi et al.
Bioorganic & medicinal chemistry, 18(21), 7675-7699 (2010-09-30)
Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems. Endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor] are located in the central and peripheral nervous systems, the
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