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Showing 1-30 of 3694 results for "E7023" within Papers
Anthony F Juritsch et al.
Analytical biochemistry, 579, 18-24 (2019-05-22)
Dextran sulfate sodium (DSS) present in the tissues of DSS-treated laboratory animals inhibits quantitative real-time qPCR (RT-qPCR) and thus may be source of experimental errors. A recent systematic review concluded that the reporting of experimental method was insufficient in a
Anna Douglas et al.
ACS nano, 9(11), 11156-11165 (2015-11-04)
Nanocrystals with quantum-confined length scales are often considered impractical for metal-ion battery electrodes due to the dominance of solid-electrolyte interphase (SEI) layer effects on the measured storage properties. Here we demonstrate that ultrafine sizes (∼4.5 nm, average) of iron pyrite
Yi-Hu Zheng et al.
Phytotherapy research : PTR, 28(9), 1342-1348 (2014-03-07)
The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytotoxicity against immortalized human
Rita Kramer et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4461-4472 (2015-07-23)
Peripheral neuropathy is a major dose-limiting side effect of paclitaxel and cisplatin chemotherapy. In the current study, we tested the involvement of a novel class of neurotoxic sphingolipids, the 1-deoxysphingolipids. 1-Deoxysphingolipids are produced when the enzyme serine palmitoyltransferase uses l-alanine
Longjian Xue et al.
Nature communications, 6, 6621-6621 (2015-03-21)
Many insect species reversibly adhere to surfaces by combining contact splitting (contact formation via fibrillar contact elements) and wet adhesion (supply of liquid secretion via pores in the insects' feet). Here, we fabricate insect-inspired fibrillar pads for wet adhesion containing
Toshifumi Hara et al.
Oncotarget, 5(17), 7635-7650 (2014-09-24)
MicroRNAs (miRNAs) regulate the expression of hundreds of genes. However, identifying the critical targets within a miRNA-regulated gene network is challenging. One approach is to identify miRNAs that exert a context-dependent effect, followed by expression profiling to determine how specific
Guomin Ai et al.
Journal of chromatography. A, 1356, 283-288 (2014-07-06)
During gas chromatography/mass spectrometry (GC-MS) analyses using water and methanol as injection solvents, hydrolysis reactions after injecting water control and alcoholysis reactions after injecting methanol control or ethanol into a GC-MS system were observed and studied. Two dominant hydrolysis/alcoholysis product
Marta N Sanz-Ortiz et al.
ACS nano, 9(10), 10489-10497 (2015-09-16)
Noble metal nanoparticles are widely used as probes or substrates for surface enhanced Raman scattering (SERS), due to their characteristic plasmon resonances in the visible and near-IR spectral ranges. Aiming at obtaining a versatile system with high SERS performance, we
Stacy M Copp et al.
ACS nano, 9(3), 2303-2310 (2015-01-30)
The remarkable precision that DNA scaffolds provide for arraying nanoscale optical elements enables optical phenomena that arise from interactions of metal nanoparticles, dye molecules, and quantum dots placed at nanoscale separations. However, control of ensemble optical properties has been limited
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index
N Ooi et al.
The Journal of antimicrobial chemotherapy, 70(2), 479-488 (2014-11-05)
To investigate the antistaphylococcal/antibiofilm activity and mode of action (MOA) of a panel of redox-active (RA) compounds with a history of human use and to provide a preliminary preclinical assessment of their potential for topical treatment of staphylococcal infections, including
Amy Y Sato et al.
Bone, 73, 60-68 (2014-12-24)
Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein translation allowing
I-Lun Hsiao et al.
Environmental science & technology, 49(6), 3813-3821 (2015-02-19)
The so-called "Trojan-horse" mechanism, in which nanoparticles are internalized within cells and then release high levels of toxic ions, has been proposed as a behavior in the cellular uptake of Ag nanoparticles (AgNPs). While several reports claim to have proved
Heng Yu et al.
Bioresource technology, 199, 188-193 (2015-09-06)
This study established a new more neutral magnesium bisulfate pretreatment (MBSP) using magnesium bisulfate as sulfonating agent for improving the enzymatic hydrolysis efficiency of corn stover. Using the MBSP with 5.21% magnesium bisulfate, 170°C and pH 5.2 for 60 min
Yuwares Malila et al.
Asian-Australasian journal of animal sciences, 28(11), 1649-1656 (2015-11-19)
Gene expression profiling has offered new insights into postmortem molecular changes associated with meat quality. To acquire reliable transcript quantification, high quality RNA is required. The objective of this study was to analyze integrity of RNA isolated from chicken skeletal
Pei Zhao et al.
ACS nano, 8(11), 11631-11638 (2014-11-05)
Using ethanol as the carbon source, self-limiting growth of AB-stacked bilayer graphene (BLG) has been achieved on Cu via an equilibrium chemical vapor deposition (CVD) process. We found that during this alcohol catalytic CVD (ACCVD) a source-gas pressure range exists
Lexiang Li et al.
American journal of translational research, 13(10), 11026-11047 (2021-11-18)
Tissue engineering is widely applied to treat osteochondral damage in osteoarthritis (OA). However, the superposition of seed cells, material scaffolds, inducing factors, and microenvironmental factors limit their practical application. We intended to develop a novel tissue engineering method for improving
Bo Jiang et al.
Applied and environmental microbiology, 81(1), 260-271 (2014-10-26)
With a completely reengineered and humanized glycosylation pathway, glycoengineered Pichia pastoris has emerged as a promising production host for the manufacture of therapeutic glycoproteins. However, the extensive genetic modifications have also negatively affected the overall fitness levels of the glycoengineered
M Argun et al.
Eye (London, England), 28(6), 752-760 (2014-03-08)
Under conditions of oxidative stress, cell apoptosis is triggered through the mitochondrial intrinsic pathway. Increased levels of reactive oxygen species (ROS) are linked to excess cell loss and mediate the initiation of apoptosis in a diverse range of cell types.
Zhengzong Wu et al.
Food chemistry, 194, 671-679 (2015-10-17)
The application of attenuated total reflectance infrared spectroscopy (ATR-IR), Raman spectroscopy (RS) and combination of ATR-IR and RS for measurements of total antioxidant capacity (TAC) and total phenolic content (TPC) of Chinese rice wine (CRW) were investigated in this study.
Quan Chi et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 990-995 (2015-02-03)
The chemiluminescence (CL) of lucigenin (Luc(2+)) can be enhanced by different alcohols in alkaline solution. The effect of different fatty alcohols on the CL of lucigenin was related to the carbon chain length and the number of hydroxyl groups. Glycerol
Marina Pierdominici et al.
Particle and fibre toxicology, 11, 74-74 (2014-12-17)
Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEP have attracted significant research attention as a factor that could influence
E Hattinger et al.
Journal of immunology research, 2015, 797421-797421 (2015-11-12)
Recently, mRNA vaccines have been introduced as a safety-optimized alternative to plasmid DNA-based vaccines for protection against allergy. However, it remained unclear whether the short persistence of this vaccine type would limit memory responses and whether the protective immune response
Lily Agranat-Tamir et al.
Cell, 181(5), 1146-1157 (2020-05-30)
We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the "Canaanite" material culture, can be modeled as descending from two sources: (1) earlier local Neolithic
Nicole H T M Dukers-Muijrers et al.
Antimicrobial agents and chemotherapy, 59(1), 121-128 (2014-10-15)
Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with
Seoungwoo Shin et al.
Molecules (Basel, Switzerland), 20(3), 3549-3564 (2015-02-24)
Glycation is an ageing reaction of naturally occurring sugars with dermal proteins, with clinical signs appearing in vivo around age 30, and increasing steadily/regularly with age. The suppleness of the dermis is affected by the formation of bridges between proteins
Gahee Jo et al.
PloS one, 9(7), e99792-e99792 (2014-07-16)
Serine protease inhibitors (SERPINs) are involved in a variety of biological processes such as blood clotting, angiogenesis, immune system, and embryogenesis. Although, of these, SERPINB12 is identified as the latest member of clade B in humans, little is known of
Lamjed Mansour et al.
Folia parasitologica, 62 (2015-05-12)
During a survey the occurrence of Kudoa quraishii Mansour, Harrath, Abd-Elkader, Alwasel, Abdel-Baki et Al Omar, 2014, recently identified in the muscles of the Indian mackerel, Rastrelliger kanagurta (Cuvier), a species of Kudoa Meglitsch, 1947 infecting oocytes of mature females
Qiao Zhao et al.
Phytochemistry, 112, 170-178 (2014-08-12)
Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas
Alexander P Scott et al.
Steroids, 88, 26-35 (2014-06-15)
Interpretation of plasma cortisol levels in wild-caught fish is confounded by the stress of capture. Measurement of cortisol metabolites in fish bile could provide a method for assessing the stress level of wild fish because the time-lag for metabolism, conjugation
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