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Showing 1-30 of 3587 results for "E7148" within Papers
AeRyon Kim et al.
Nature communications, 5, 5369-5369 (2014-11-22)
Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-processing system composed of defined components. We use the system to characterize steps in
Justin P Wagner et al.
Journal of pediatric surgery, 49(8), 1319-1324 (2014-08-06)
Hirschsprung's disease is characterized by a developmental arrest of neural crest cell migration, causing distal aganglionosis. Transplanted cells derived from the neural crest may regenerate enteric ganglia in this condition. We investigated the potential of skin-derived precursor cells (SKPs) to
Sayan Basu et al.
Science translational medicine, 6(266), 266ra172-266ra172 (2014-12-17)
Conventional allograft therapy for corneal scarring is widespread and successful, but donor tissue is not universally available, and some grafts fail owing to rejection and complications such as endothelial failure. We investigated direct treatment of corneal scarring using autologous stem
Sophie J Smither et al.
Journal of clinical microbiology, 53(10), 3148-3154 (2015-07-17)
Rapid inactivation of Ebola virus (EBOV) is crucial for high-throughput testing of clinical samples in low-resource, outbreak scenarios. The EBOV inactivation efficacy of Buffer AVL (Qiagen) was tested against marmoset serum (EBOV concentration of 1 × 10(8) 50% tissue culture
Susanne Müller et al.
Applied and environmental microbiology, 81(1), 203-210 (2014-10-19)
Biofilm formation is a common mechanism for surviving environmental stress and can be triggered by both intraspecies and interspecies interactions. Prolonged predator-prey interactions between the soil bacterium Myxococcus xanthus and Bacillus subtilis were found to induce the formation of a
Everett J Moding et al.
Science translational medicine, 7(278), 278ra34-278ra34 (2015-03-13)
Cancer clinics currently use high-dose stereotactic body radiation therapy as a curative treatment for several kinds of cancers. However, the contribution of vascular endothelial cells to tumor response to radiation remains controversial. Using dual recombinase technology, we generated primary sarcomas
Kh Iu Nedoshytko
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 154-162 (2014-02-01)
The state of antioxidant system and fatty acid composition of lipids in the liver tissues of rats of different sex at the ethanol and tetracycline action and at the influence of biologically active additives (BAA) "Alpha + Omega" at a
C Egloff et al.
Osteoarthritis and cartilage, 22(11), 1886-1893 (2014-08-12)
Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination
P C J Schmeits et al.
Archives of toxicology, 89(12), 2325-2337 (2014-09-17)
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and
Shogo Sasaki et al.
Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)
We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of
K Krishnanunni et al.
Journal of food science and technology, 52(5), 2572-2584 (2015-04-22)
The objective of this study is to analyze the chemical composition and volatiles present in two medicinal rice varieties of "karungkuravai" and "mappilai samba" and to investigate their total phenolic content and bio activity. Chemical composition of the rice varieties
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Mahesh Mohan et al.
Journal of immunology (Baltimore, Md. : 1950), 194(1), 291-306 (2014-12-03)
Persistent gastrointestinal inflammation, a hallmark of progressive HIV/SIV infection, causes disruption of the gastrointestinal epithelial barrier, microbial translocation, and generalized immune activation/inflammation driving AIDS progression. Apart from protein regulators, recent studies strongly suggest critical roles for microRNAs (miRNAs) in regulating
Yi-Fei Chen et al.
International journal of molecular medicine, 34(6), 1591-1598 (2014-10-17)
The difficulties faced in the effective treatment of ovarian cancer are multifactorial, but are mainly associated with relapse and drug resistance. Cancer stem-like cells have been reported to be an important contributor to these hindering factors. In this study, we
Mauricio Montaño-Rendón et al.
Zootaxa, 4034(3), 495-514 (2015-12-02)
The Rufous-backed Robin (Turdus rufopalliatus) is endemic to deciduous and semideciduous tropical forests of western Mexico. Of the currently recognized subspecies, T. r. graysoni, from the Tres Marías Islands and nearby coastal Nayarit, has been considered a separate species; however
Dan Bi Lee et al.
The Journal of dermatological treatment, 25(6), 523-528 (2013-12-03)
Although low-fluence 1064-nm Q-switched Nd:YAG laser (QSNYL) is widely used for the treatment of melasma, multiple treatments are necessary for clinical improvement. Superficial chemical peeling using Jessner's solution has been used for treatment of melasma conventionally. To evaluate the additional
David R Owen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(6), 989-994 (2014-03-20)
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential (BPND). Here, we used
Simon Puttick et al.
Molecular imaging, 14, 385-399 (2015-07-29)
Noninvasive imaging is a critical technology for diagnosis, classification, and subsequent treatment planning for patients with glioblastoma. It has been shown that the EphA2 receptor tyrosine kinase (RTK) is overexpressed in a number of tumors, including glioblastoma. Expression levels of
Seshadri Reddy Ankireddy et al.
International journal of nanomedicine, 10 Spec Iss, 113-119 (2015-09-09)
Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson's disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to
Yan Yang et al.
International journal of pharmaceutics, 467(1-2), 113-122 (2014-03-26)
Artemisinin (ART) and its analogues, such as dihydroartesunate (DHA) and artesunate (ATS), are sesquiterpene lactones with anticancer activities. Transferrin (Tf) receptor is frequently overexpressed in cancer cells. In order to improve the delivery and the anticancer activity of ART and
Sebastian Antoń et al.
Protoplasma, 252(6), 1587-1601 (2015-03-17)
Nectaries are common in Ranunculaceae. These secretory structures, however, have not been studied in detail despite their importance in plant-animal interactions, and data relating to the structure of nectary spurs, which are so characteristic of several genera of this family
Ramla Gary et al.
Biomedical optics express, 6(12), 4738-4748 (2015-12-30)
Immunofluorescence is a biological technique that allows displaying the localization of the target molecule through a fluorescent microscope. We used a combination of gold nanoparticles and the fluorescein isothiocianate, FITC, as optical contrast agents for laser scanning confocal microscopy imaging
Li-na Sun et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 1079-1088 (2014-12-03)
Epithelial-mesenchymal transition (EMT) is recognized to play a key role in diabetic nephropathy (DN). Curcumin, the main active component of turmeric extracted from the roots of the Curcuma longa plant, has been reported for its anti-fibrotic effects in kidney fibrosis. The
Junya Sato et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 41(8), 981-985 (2014-08-19)
Subcutaneous implantation type central venous ports(CV ports)are used in chemotherapy. Here, we prospectively examined the frequency of CV port-related infections when the disinfectant was changed from 10% povidone iodine to 1% chlorhexidine ethanol or 70% ethanol. The subjects were patients
Alizé Pennec et al.
Carbohydrate research, 402, 50-55 (2014-12-17)
A random mutagenesis of the arabinofuranosyl hydrolase Araf51 has been run in order to have access to efficient biocatalysts for the synthesis of alkyl arabinofuranosides. The mutants were selected on their ability to catalyze the transglycosylation reaction of p-nitrophenyl α-L-arabinofuranoside
Frances Orton et al.
Toxicology and applied pharmacology, 278(3), 201-208 (2013-09-24)
Many xenobiotics have been identified as in vitro androgen receptor (AR) antagonists, but information about their ability to produce combined effects at low concentrations is missing. Such data can reveal whether joint effects at the receptor are induced at low
Elvan Bakar et al.
Environmental toxicology, 30(12), 1406-1415 (2014-06-17)
We aimed to investigate of protective role of proanthocyanidin (PA) and vitamin E (vit E) against to toxic effect of formaldehyde (FA). Twenty-eight Wistar albino rats were divided into four groups: control group, rats treated with FA intraperitoneal (i.p.) (10
Oscar Verho et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(15), 5909-5915 (2015-03-18)
Herein, we describe the use of Pd nanoparticles immobilized on an amino-functionalized siliceous mesocellular foam for the catalytic oxidation of H2O. The Pd nanocatalyst proved to be capable of mediating the four-electron oxidation of H2O to O2, both chemically and
Yang Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 52-58 (2014-05-03)
A novel TiO2/diatomite composite (TD) was prepared and then characterized by scanning electron microscope (SEM) and Fourier Transform Infrared (FTIR). The results of SEM showed that after modification, the porous surface of diatomite was covered with TiO2. Both diatomite and
Adriana Egui et al.
PloS one, 10(3), e0122115-e0122115 (2015-03-31)
It has been reported that the immune response mediated by T CD8+ lymphocytes plays a critical role in the control of Trypanosoma cruzi infection and that the clinical symptoms of Chagas disease appear to be related to the competence of
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