E7280

Applied Filters:

Keyword:'E7280'

Showing 1-8 of 8 results for "E7280" within Papers

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.

Jiani Wang et al.

Scientific reports, 10(1), 12785-12785 (2020-08-01)

Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum

The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.

J A Caruso et al.

Oncogene, 34(27), 3556-3567 (2014-09-10)

The serine protease inhibitor, elafin, is a critical component of the epithelial barrier against neutrophil elastase (NE). Elafin is downregulated in the majority of breast cancer cell lines compared with normal human mammary epithelial cells (HMECs). Here, we evaluated the

Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.

Joseph A Caruso et al.

Breast cancer research : BCR, 16(6), 3417-3417 (2015-01-01)

Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In this study, we hypothesized that elafin is downregulated during breast and ovarian tumorigenesis. We examined elafin

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.

T Dau et al.

Scientific reports, 6, 35413-35413 (2016-10-16)

High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.

Lingling Shu et al.

Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)

Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.

Viraj J Jasinghe et al.

BioResearch open access, 2(2), 128-137 (2013-04-18)

Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both

Gut microbial I?-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.

Edwinson, et al.

Nature microbiology, 7, 680-694 (2022)

Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.

Renata Curciarello et al.

Journal of inflammation research, 13, 233-243 (2020-06-18)

Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive

Page 1 of 1