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Showing 1-30 of 9219 results for "E9884" within Papers
Kamala Pant et al.
Environmental and molecular mutagenesis, 56(9), 777-787 (2015-04-29)
14-Hydroxycodeinone (14-HC) is an α,β-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Comet Assay to determine if the slight decrease in % Tail DNA
Soochan Kim et al.
Immunobiology, 221(1), 94-102 (2015-08-25)
The cellular prion protein is expressed in almost all tissues, including the central nervous system and lymphoid tissues. To investigate the effects of the prion protein in lymphoid cells and spleen structure formation, we used prion protein-deficient (Prnp(0/0)) Zürich I
Shankar Munusamy et al.
American journal of physiology. Renal physiology, 309(8), F731-F743 (2015-08-21)
We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these changes. We compared two normotensive genetic mouse models of obesity, leptin-deficient
Chunzhao Zhao et al.
PLoS genetics, 10(5), e1004389-e1004389 (2014-05-17)
Mitogen-activated protein (MAP) kinase signaling cascades play important roles in the regulation of plant defense. The Raf-like MAP kinase kinase kinase (MAPKKK) EDR1 negatively regulates plant defense responses and cell death. However, how EDR1 functions, and whether it affects the
Fuyao Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(30), 3676-3685 (2015-04-29)
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic
Abdulkader Albasri et al.
Anticancer research, 34(8), 3969-3974 (2014-07-31)
To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on
Yoon Kyung Kwon et al.
Chemical & pharmaceutical bulletin, 63(12), 1076-1080 (2015-12-04)
The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used
William F Borschel et al.
The Journal of biological chemistry, 290(44), 26846-26855 (2015-09-16)
Among glutamate-gated channels, NMDA receptors produce currents that subside with unusually slow kinetics, and this feature is essential to the physiology of central excitatory synapses. Relative to the homologous AMPA and kainate receptors, NMDA receptors have additional intersubunit contacts in
Shuai Wu et al.
Molecules (Basel, Switzerland), 20(10), 18704-18716 (2015-10-27)
Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal
Noriko Takahashi et al.
Nature communications, 6, 8531-8531 (2015-10-07)
It remains unclear how readiness for Ca(2+)-dependent exocytosis depends on varying degrees of SNARE complex assembly. Here we directly investigate the SNARE assembly using two-photon fluorescence lifetime imaging (FLIM) of Förster resonance energy transfer (FRET) between three pairs of neuronal
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Tae Mi Yoon et al.
Oncology reports, 33(4), 1717-1722 (2015-02-25)
The transcription factor, early growth response 1 (EGR1) belongs to the early growth response family. EGR1 regulates the transactivation of genes involved in growth inhibition and apoptosis by ionizing radiation. The aims of the present study were to evaluate the expression
Jennifer R Fleming et al.
PLoS neglected tropical diseases, 8(6), e2936-e2936 (2014-06-13)
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for
Hai-Yu Yang et al.
Drug and alcohol dependence, 139, 53-59 (2014-04-02)
It has been shown that opioid dependence-related neuronal plasticity may rely not only on protein synthesis, but also on protein degradation, mainly mediated by ubiquitin-proteasome system (UPS). The aim of the present study was to determine the effect of morphine
Serafim Kiriakidis et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2814-2827 (2015-04-04)
Factor-inhibiting hypoxia-inducible factor (HIF)-1 (FIH-1) is an asparaginyl β-hydroxylase enzyme that was initially found to hydroxylate the HIF-α, preventing its transcriptional activity and leading to adaptive responses to hypoxia. More recently, other substrates, such as neurogenic locus notch homolog (Notch)
Lauriane Padet et al.
Immunobiology, 219(9), 687-694 (2014-05-31)
Allograft rejection and graft-versus-host disease (GvHD) are frequent complications following solid organ or stem cell transplantation in which T cell activation plays a central role. Despite the development of new immunosuppressive drugs that improve the success rate of transplantation, allograft
Ilona Joniec-Maciejak et al.
Pharmacological reports : PR, 66(4), 660-669 (2014-06-21)
The aim of this study was to examine the effect of AAV2-hIL-10 (vector containing cDNA for human interleukin 10) on dopaminergic system activity (measured as DA levels and TH mRNA expression in mouse striata), and other monoamine and amino acid
Sally Aldous et al.
International journal of cardiology, 177(1), 182-186 (2014-12-17)
The aim of this study is to compare a new improved point of care cardiac troponin assay (new POC-cTnI) with 1. its predecessor (old POC-cTnI) and 2. a high sensitivity assay (hs-cTnI) for the diagnosis of acute myocardial infarction (AMI)
Bo Yuan et al.
Cancer science, 106(7), 819-824 (2015-05-06)
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death in China. Deregulation of microRNA (miRNA) contributes to HCC development by influencing cell growth, apoptosis, migration or invasion. It has been proved that miR-940 plays important roles in various
Megan A Sheridan et al.
Nature protocols, 15(10), 3441-3463 (2020-09-11)
The human placenta is essential for successful reproduction. There is great variation in the anatomy and development of the placenta in different species, meaning that animal models provide limited information about human placental development and function. Until recently, it has
Alexandra Jaeger et al.
International journal of biological sciences, 11(9), 1006-1015 (2015-07-30)
The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. We showed previously that expression of the porcine beta-2 AR gene (ADRB2) is affected by cis-regulatory polymorphisms. These are
Olivia Jane Scully et al.
Experimental biology and medicine (Maywood, N.J.), 240(7), 846-853 (2015-01-13)
Complement component 1, q subcomponent binding protein (C1QBP), is a multi-compartmental protein with higher mRNA expression reported in breast cancer tissues. This study evaluated the association between immunohistochemical expression of the C1QBP protein in breast cancer tissue microarrays (TMAs) and
Elena Kurenova et al.
Cell cycle (Georgetown, Tex.), 13(16), 2542-2553 (2014-12-09)
Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the
Stéphanie Thomas et al.
Clinical immunology (Orlando, Fla.), 157(2), 277-293 (2015-01-07)
The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight
Upul D Halambage et al.
Antimicrobial agents and chemotherapy, 59(9), 5190-5195 (2015-06-17)
Despite the availability of >30 effective drugs for managing HIV-1 infection, no current therapy is curative, and long-term management is challenging owing to the emergence and spread of drug-resistant mutants. Identification of drugs against novel HIV-1 targets would expand the
Yeonjoong Yong et al.
Fitoterapia, 98, 184-191 (2014-07-16)
Semaphorins are a class of membrane-bound and secreted proteins. They have been found to regulate basic cell functions such as axonal growth cone guidance and recent studies have focused on their effect on tumor progression. Semaphorin 3B (Sema3B) particularly is
Xiaoli Zhang et al.
Reproductive biomedicine online, 30(5), 514-521 (2015-03-17)
We previously reported that bone morphogenetic protein 4/drosophila mothers against decapentaplegic protein (BMP4/Smad) signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not
Ling Fu et al.
Extremophiles : life under extreme conditions, 19(4), 829-840 (2015-05-29)
Deep-sea hydrothermal vents are a natural habitat for thermophiles, in which contain plenty of enzymes that can function at high temperatures. In this work, we constructed a fosmid library in Escherichia coli using metagenomic DNA isolated from a chimney sample
Mahmood M Alam et al.
Nature communications, 6, 7285-7285 (2015-07-08)
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global
Hae Mi Lee et al.
Cellular immunology, 290(1), 52-61 (2014-06-01)
The major factors and mechanisms by which natural killer (NK) cells are inhibited in cancer patients have not yet been well defined. In this study, we conducted a comparative analysis of the effects of TGF-β, IL-10, and IL-4 on primary
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