Search Within
ECM550
Applied Filters:
Keyword:'ECM550'
Showing 1-30 of 110 results for "ECM550" within Papers
Xiangrui Li et al.
Journal of experimental & clinical cancer research : CR, 37(1), 39-39 (2018-02-28)
The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and
The effect of a novel frizzled 8-related antiproliferative factor on in vitro carcinoma and melanoma cell proliferation and invasion.
Kristopher R Koch,Chen-Ou Zhang,Piotr Kaczmarek,Joseph Barchi,Li Guo,Hanief M Shahjee,Susan Keay
Investigational New Drugs null
Philip R Brauer et al.
Cell communication & adhesion, 24(1), 1-10 (2018-03-03)
Kru¨ppel like factor 4 (KLF4) is a transcription factor that regulates genes related to differentiation and proliferation. KLF4 also plays a role in metastasis via epithelial to mesenchymal transition. Here, we investigate the function of Klf4 in migration and invasion
Zheng Zhou et al.
Experimental and therapeutic medicine, 14(4), 3665-3673 (2017-10-19)
MicroRNAs (miRs) have a critical role in the development and malignant progression of osteosarcoma (OS), but the underlying mechanisms have largely remained elusive. The present study aimed to explore the regulatory role of miR-138 in OS growth and metastasis and
Caixia Gou et al.
The British journal of radiology, 93(1108), 20190154-20190154 (2020-01-17)
This work focused on the function role and underlying mechanism of BLACAT1 in regulating the radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cells via PSEN1. BLACAT1 and PSEN1 expression in HNSCC tissues and cells were measured by qRT-PCR.
Sanjeev Shukla et al.
PloS one, 8(1), e53527-e53527 (2013-01-12)
Disease aggressiveness remains a critical factor to the progression of prostate cancer. Transformation of epithelial cells to mesenchymal lineage, associated with the loss of E-cadherin, offers significant invasive potential and migration capability. Recently, Special AT-rich binding protein (SATB1) has been
Daniel Noujaim et al.
Oncogene, 21(29), 4549-4557 (2002-06-27)
Neuroblastoma is a peripheral nervous system tumor that accounts for 8-10% of all solid childhood tumors. N-Myc is the most reliable prognostic indicator for neuroblastoma. Bcl-2 is detected in 40-60% of primary neuroblastoma tumors and demonstrates anti-apoptotic action by conferring
Shang-Wen Dong et al.
Oncology letters, 9(1), 341-346 (2014-12-02)
The present study examined the role of the PRDI-BF1-RIZ (PR) domain of tumor suppressor retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) as an anticancer domain and its ability to induce apoptosis in esophageal squamous cell carcinoma (ESCC) cells. The TE13
Shreeta Chakraborty et al.
The Journal of biological chemistry, 292(16), 6600-6620 (2017-02-27)
Endothelial nitric-oxide synthase (eNOS) and its bioactive product, nitric oxide (NO), mediate many endothelial cell functions, including angiogenesis and vascular permeability. For example, vascular endothelial growth factor (VEGF)-mediated angiogenesis is inhibited upon reduction of NO bioactivity both in vitro and
Jessica Wagner et al.
Cell cycle (Georgetown, Tex.), 16(19), 1790-1799 (2017-05-11)
Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone
Wongwarut Boonyanugomol et al.
Medicina (Kaunas, Lithuania), 57(8) (2021-08-28)
Background and Objectives: The effects of Ocimum tenuiflorum essential oil (OTEO) against gastric cancer remain unknown and merit investigation. Materials and Methods: In the present study, the anti-cancer activity of OTEO was examined in a human gastric cancer cell line
Ch Gialeli et al.
Biochimica et biophysica acta, 1840(8), 2549-2559 (2014-03-04)
Breast cancer-endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the context of tumor perfusion and relatively little is known regarding the effects of such paracrine interactions on the expression of
Jessica Wagner et al.
The Journal of clinical investigation, 128(6), 2325-2338 (2018-03-14)
ONC201 is a first-in-class, orally active antitumor agent that upregulates cytotoxic TRAIL pathway signaling in cancer cells. ONC201 has demonstrated safety and preliminary efficacy in a first-in-human trial in which patients were dosed every 3 weeks. We hypothesized that dose
Ning Duan et al.
American journal of cancer research, 11(6), 2637-2653 (2021-07-13)
ALL1 fused gene from chromosome 1q (AF1Q) functions as an oncogene in several types of cancers, but it has not been observed in osteosarcoma. In this study, we revealed that AF1Q was overexpressed in multiple osteosarcoma cell lines, and its
Xiaojun Li et al.
International journal of clinical and experimental pathology, 11(7), 3533-3541 (2018-07-01)
Myeloid leukemia factor 1 (MLF1) is a protein involved in myeloid cell differentiation which regulates the cell cycle and the expression of numerous genes. The role of MLF1 in hematologic cancers is well established; however, its role in lung adenocarcinoma
Jayakumar Vadakekolathu et al.
Cell death & disease, 9(3), 344-344 (2018-03-03)
Cell-cell adhesions constitute the structural "glue" that retains cells together and contributes to tissue organisation and physiological function. The integrity of these structures is regulated by extracellular and intracellular signals and pathways that act on the functional units of cell
Yong Lu et al.
Oncology letters, 20(5), 186-186 (2020-09-22)
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. SAR1 gene homolog B (SAR1B) is a GTPase that has been reported to have a central role in the regulation of lipid homeostasis and is associated with numerous diseases.
Yan Zhao et al.
Aging, 13(14), 18498-18514 (2021-07-23)
Breast cancer (BC) is a common malignant tumor in females. The challenge in treating BC is overcoming chemoresistance. Exosome-mediated transfer of miRNAs is a molecule-shuttle in intercellular communication. Thus, we aimed to investigate whether exosomal miRNA-205 could affect chemoresistance and
Jiadi Lv et al.
The EMBO journal, 40(2), e106123-e106123 (2020-12-05)
Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogeneous cell population is a daunting challenge. Here, we show that microfluidic devices can be used to sort marker-based heterogeneous cancer stem cells (CSC) into mechanically stiff and soft
Fu Yang et al.
Molecular cell, 49(6), 1083-1096 (2013-02-12)
Recently, long noncoding RNAs (lncRNAs) were found to be dysregulated in a variety of tumors. However, it remains unknown how and through what molecular mechanisms the expression of lncRNAs is controlled. In this study, we found that the lncRNA Low
Haiyan Zhai et al.
Oncotarget, 6(23), 19735-19746 (2015-05-20)
Colorectal cancer (CRC) is the third highest mortality cancer in the United States and frequently metastasizes to liver and lung. Smad2 is a key element downstream of the TGF-β signaling pathway to regulate cancer metastasis by promoting epithelial to mesenchymal
Xiuying Xiao et al.
Journal of translational medicine, 11, 151-151 (2013-06-22)
Colorectal cancer (CRC) remains one of the most common cancers worldwide. We observed that MUC20 was significantly up-regulated in CRC patients with poor prognosis based on the microarray analysis. However, little is known about the role of MUC20 in CRC.
Jian-Feng Zheng et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 1562-1568 (2015-06-03)
Recent clinical studies have linked polymorphisms in the xeroderma pigmentosum group D (XPD) gene, a key repair gene involved in nucleotide excision repair, to increased risk of hepatocellular carcinoma (HCC). However, the cellular effects of XPD expression in cultured HCC
Xunfa Liu et al.
Oncotarget, 8(70), 114829-114838 (2018-02-01)
Circular RNAs (circRNAs) are a type of endogenous noncoding RNA which have been verified to participate in numerous pathophysiological processes. However, the underlying role of circRNAs in osteosarcoma tissue is still unidentified. Our study aims to investigate the circRNA expression
Li-Ping Luo et al.
Asian Pacific journal of cancer prevention : APJCP, 15(15), 6219-6225 (2014-08-16)
Increasing evidence from animal, epidemiological and clinical investigations suggest that dietary anthocyanins have potential to prevent chronic diseases, including cancers. It is also noteworthy that human epidermal growth factor receptor 2 (ErbB2) protein overexpression or ErbB2 gene amplification has been
Husam Babikir et al.
Genome biology, 22(1), 311-311 (2021-11-13)
Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy, and correlate with distinct tumor microenvironments.
Vanessa Arcolia et al.
International journal of oncology, 51(3), 760-770 (2017-07-06)
Fine-needle aspiration (FNA) is the most commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. Based on multifunctionality of the endogenous galectin-1, we aimed to assess its
Jung-Sun Park et al.
Journal of pharmaceutical sciences, 97(9), 4011-4019 (2008-02-02)
All-trans retinoic acid (ATRA)-incorporated nanoparticles of methoxy poly(ethylene glycol) (MPEG)-grafted chitosan were prepared through ion-complex formation between ATRA and chitosan. This nanoparticle has around 100 nm of diameter and favorable reconstitution properties. ATRA-incorporated nanoparticles has almost similar cytotoxicity against CT-26
Carla L Alves et al.
Breast cancer research : BCR, 20(1), 60-60 (2018-06-21)
Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the specific molecules and pathways involved in these altered features remain
Ewa Kotula et al.
Cell cycle (Georgetown, Tex.), 14(12), 1961-1972 (2015-05-29)
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a major role in DNA damage signaling and repair and is also frequently overexpressed in tumor metastasis. We used isogenic cell lines expressing different levels of DNA-PKcs to investigate the role of
Page 1 of 4