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Showing 1-30 of 630 results for "F3777" within Papers
Valeriana Cesarini et al.
Oncotarget, 8(8), 13223-13239 (2017-01-19)
Expression of type 5 phosphodiesterase (PDE5), a cGMP-specific hydrolytic enzyme, is frequently altered in human cancer, but its specific role in tumorigenesis remains controversial. Herein, by analyzing a cohort of 69 patients affected by glioblastoma multiforme (GBM) who underwent chemo-
Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds.
Mirastschijski U, et al.
Experimental Cell Research, 299(2), 465-475 (2004)
P Olof Olsson et al.
PloS one, 12(8), e0182973-e0182973 (2017-08-23)
Tumor barrier function in carcinoma represents a major challenge to treatment and is therefore an attractive target for increasing drug delivery. Variables related to tumor barrier include aberrant blood vessels, high interstitial fluid pressure, and the composition and structure of
Qiaozhen Liu et al.
Nature genetics, 51(4), 728-738 (2019-02-20)
Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junctions has been proposed to comprise endogenous stem cells for lung regeneration. However
Kirsten A Turlo et al.
Developmental biology, 365(1), 23-35 (2012-02-15)
β1 integrin has been shown to contribute to vascular smooth muscle cell differentiation, adhesion and mechanosensation in vitro. Here we showed that deletion of β1 integrin at the onset of smooth muscle differentiation resulted in interrupted aortic arch, aneurysms and
Zhiyong Lei et al.
Journal of cellular and molecular medicine, 19(8), 1994-2005 (2015-05-07)
Arteriogenesis is a complicated process induced by increased local shear-and radial wall-stress, leading to an increase in arterial diameter. This process is enhanced by growth factors secreted by both inflammatory and endothelial cells in response to physical stress. Although therapeutic
Jaeryung Kim et al.
The Journal of clinical investigation, 127(10), 3877-3896 (2017-09-19)
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm's canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces
Pieter-Jan D F Guns et al.
British journal of pharmacology, 159(2), 326-336 (2010-01-07)
P2Y nucleotide receptors are involved in the regulation of vascular tone, smooth muscle cell (SMC) proliferation and inflammatory responses. The present study investigated whether they are involved in atherosclerosis. mRNA of P2Y receptors was quantified (RT-PCR) in atherosclerotic and plaque-free
Allison N Lau et al.
eLife, 9 (2020-07-11)
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time
Anis Hanna et al.
Matrix biology : journal of the International Society for Matrix Biology, 99, 18-42 (2021-05-29)
Tissue injury results in profound alterations in the collagen network, associated with unfolding of the collagen triple helix, proteolytic degradation and generation of fragments. In the infarcted myocardium, changes in the collagen network are critically involved in the pathogenesis of
Matthew MacGregor Sharp et al.
Acta neuropathologica communications, 8(1), 131-131 (2020-08-11)
White matter hyperintensities (WMH) occur in association with dementia but the aetiology is unclear. Here we test the hypothesis that there is a combination of impaired elimination of interstitial fluid from the white matter together with a degree of hypoxia
Brittany G Durgin et al.
JCI insight, 4(19) (2019-09-06)
Nitric oxide regulates BP by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). We previously showed that sGC heme iron reduction (Fe3+ → Fe2+) is modulated by cytochrome b5 reductase
Monika Krampert et al.
Laboratory investigation; a journal of technical methods and pathology, 88(11), 1204-1214 (2008-09-03)
Platelet-derived growth factor (PDGF) isoforms stimulate cell proliferation, migration and survival. We recently generated mice carrying a gain-of-function mutation within the activation loop of PDGF beta-receptor (PDGFR-beta D849N). Embryonic fibroblasts derived from these mice show elevated basal phosphorylation and altered
Sungwoon Lee et al.
The Journal of clinical investigation, 127(2), 457-471 (2016-12-20)
Controlled angiogenesis and lymphangiogenesis are essential for tissue development, function, and repair. However, aberrant neovascularization is an essential pathogenic mechanism in many human diseases, including diseases involving tumor growth and survival. Here, we have demonstrated that mice deficient in C-type
Shreya Raghavan et al.
American journal of physiology. Gastrointestinal and liver physiology, 299(2), G430-G439 (2010-06-19)
We have previously developed bioengineered three-dimensional internal anal sphincter (IAS) rings from circular smooth muscle cells isolated from rabbit and human IAS. We provide proof of concept that bioengineered mouse IAS rings are neovascularized upon implantation into mice of the
Karin Pfisterer et al.
The Journal of investigative dermatology, 135(1), 130-141 (2014-07-23)
The skin has to effectively combat external attacks, while maintaining skin immune homeostasis under steady-state conditions. To fulfill these challenging tasks, the dermis harbors a variety of heterogeneous cell types that are able to suppress T-cell proliferation similar to bone
Nhat Minh Nguyen et al.
The world journal of men's health, 39(1), 131-138 (2019-09-10)
Proper functional and structural integrity of nervous and vascular system in urinary bladder plays an important role in normal bladder function and the disruption of these structures is known to be related to lower urinary tract symptoms. Here, we present
Abby L Manthey et al.
Investigative ophthalmology & visual science, 55(8), 5445-5455 (2014-08-02)
Posterior capsular opacification (PCO), the most prevalent side effect of cataract surgery, occurs when residual lens epithelial cells (LECs) undergo fiber cell differentiation or epithelial-to-mesenchymal transition (EMT). Here, we used a murine cataract surgery model to investigate the role of
Jung-Hyun Lee et al.
EBioMedicine, 6, 103-113 (2016-05-24)
Antiretroviral therapy (ART) efficiently suppresses HIV replication but immune activation and low CD4 T cell counts often persist. The underlying mechanism of this ART-resistant pathogenesis is not clear. We observed that levels of plasma extracellular vesicles (pEV) are strongly elevated
Soon Yew Tang et al.
Circulation, 129(17), 1761-1769 (2014-02-13)
Placebo-controlled trials of nonsteroidal anti-inflammatory drugs selective for inhibition of cyclooxygenase-2 (COX-2) reveal an emergent cardiovascular hazard in patients selected for low risk of heart disease. Postnatal global deletion of COX-2 accelerates atherogenesis in hyperlipidemic mice, a process delayed by
Navin Gupta et al.
Science translational medicine, 14(634), eabj4772-eabj4772 (2022-03-03)
Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results in fibrotic tissue replacing normal kidney
Zongbo Wei et al.
Cells, 11(13) (2022-07-10)
Posterior capsule opacification (PCO) is a frequent complication after cataract surgery, and advanced PCO requires YAG laser (Nd: YAG) capsulotomy, which often gives rise to more complications. Lens epithelial cell (LEC) proliferation and transformation (i.e., epithelial-mesenchymal transition (EMT)) are two
Jung-Hyun Lee et al.
EBioMedicine, 77, 103903-103903 (2022-02-28)
Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A potential role of such vesicles in AD pathology is unexplored.
Katsuhito Fujiu et al.
Science and technology of advanced materials, 13(6), 064218-064218 (2012-12-28)
SUS316L stainless steel and cobalt-chromium and platinum-chromium alloys are widely used platforms for coronary stents. These alloys also contain nickel (Ni), which reportedly induces allergic reactions in some subjects and is known to have various cellular effects. The effects of
Jan-Niklas Schulz et al.
Journal of cell science, 129(4), 706-716 (2016-01-10)
Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP is also a
Jennifer V Robertson et al.
Molecular vision, 19, 684-695 (2013-04-06)
Extracellular matrix remodeling is thought to have profound effects on tissue architecture and associated function. We have shown previously that overexpression of transforming growth factor beta (TGFβ), which stimulates matrix accumulation, results in altered morphology, cataract, and ocular hypertension in
Yeojin Lee et al.
The Journal of experimental medicine, 218(3) (2020-11-06)
The liver maintains hematopoietic stem cells (HSCs) during development. However, it is not clear what cells are the components of the developing liver niche in vivo. Here, we genetically dissected the developing liver niche by systematically determining the cellular source
K-Raman Purushothaman et al.
Journal of the American College of Cardiology, 60(2), 112-119 (2012-07-07)
The purpose of this study was to test the hypothesis that increased oxidative stress is associated with apoptosis in human plaques with the haptoglobin (Hp) 2-2 genotype. Intraplaque hemorrhage releases free hemoglobin (Hb). Impaired Hb clearance induces oxidative stress leading
Cristi L Galindo et al.
Journal of the American Heart Association, 3(5), e000773-e000773 (2014-10-25)
Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI)
Silvia Affo et al.
Cancer cell, 39(6), 866-882 (2021-05-01)
Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma (ICC), a highly desmoplastic liver tumor. Genetic tracing, single-cell RNA sequencing, and ligand-receptor analyses uncovered hepatic stellate
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