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Showing 1-30 of 237 results for "F3879" within Papers
Shuxia Fan et al.
Bio-protocol, 8(18), e3018-e3018 (2018-09-20)
Blood platelets are critical for hemostasis and thrombosis, but also play diverse roles during immune responses. We have recently reported that platelets migrate at sites of infection in vitro and in vivo. Importantly, platelets use their ability to migrate to
V S Rogovskiĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(3), 23-26 (2013-06-19)
The ability of dihydroquercetin to inhibit the oxidation of fibrinogen has been evaluated. It is established that dihydroquercetin inhibits oxidation of fibrinogen by ozone, thus preventing oxidative modification of fibrinogen and preserving its functional activity.
Etheresia Pretorius et al.
Cardiovascular diabetology, 16(1), 141-141 (2017-11-04)
We have previously shown that many chronic, inflammatory diseases are accompanied, and possibly partly caused or exacerbated, by various coagulopathies, manifested as anomalous clots in the form of 'dense matted deposits'. More recently, we have shown that these clots can
Cristina Solomon et al.
Anesthesia and analgesia, 117(5), 1054-1062 (2013-10-11)
The viscoelastic functional fibrinogen (FF) and FIBTEM assays measure the contribution of fibrin to clot strength. Inhibition of platelet function is a necessary precondition for these tests to work. We investigated a novel test for measuring fibrin-based clotting, FIBTEM PLUS
Fajer Almesbah et al.
Journal of neurosurgery. Pediatrics, 12(6), 615-621 (2013-10-08)
The frequency with which routine preoperative blood test results predict perioperative or postoperative complications is insignificant. The unnecessary ordering of routine tests increases the financial costs and patients' distress. The authors evaluated the effects of routine preoperative testing on patient
D Adelmann et al.
British journal of anaesthesia, 113(4), 628-633 (2014-05-30)
Postoperative haemorrhage in neurosurgery is associated with significant morbidity and mortality. There is controversy whether or not factor XIII (FXIII) deficiency leads to bleeding complications after craniotomy. Decreased fibrinogen levels have been associated with an increased incidence of bleeding complications
Anna Kobsar et al.
Transfusion, 54(4), 1008-1014 (2013-08-06)
Platelet storage lesion (PSL) considerably decreases the quality of platelets (PLTs) in concentrates characterized by a loss of signaling responses to agonists and impaired PLT activation, secretion, and aggregation. To understand the role of inhibitory signaling pathways in the mechanism
Meriem Ameziani et al.
The protein journal, 39(5), 574-590 (2020-09-23)
The current report focuses on purification, structural and functional characterization of Cerastategrin from Cerastes cerastes venom, a novel basic disintegrin (pI 8.36) with 128 amino acid residues and a molecular weight of 13 835.25 Da measured by MALDI-MSMS. The 3D structure
Pauline Brevet et al.
Frontiers in immunology, 12, 733511-733511 (2021-10-26)
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate their prognostic value. 331 patients (184 RA and 147
Anastasia Koroleva et al.
Biofabrication, 4(1), 015001-015001 (2012-01-20)
Fabrication of three-dimensional (3D) fibrin scaffolds with tightly controllable pore sizes and interconnections has been investigated. The scaffolds were produced using a combination of two-photon polymerization (2PP) and micromolding techniques. Master structures were fabricated by 2PP and regenerated in fibrin
Anna Agren et al.
Anesthesia and analgesia, 118(5), 933-935 (2014-05-02)
Fibrinogen is of crucial importance in patients with ongoing bleeding. In this study, we compared fibrinogen concentration measured by thrombelastography (TEG®) with fibrinogen plasma concentration determined by Clauss. Sixty-three surgical patients and 38 healthy controls were included. For the whole
Daniel Dashevsky et al.
Toxicology letters, 337, 91-97 (2020-11-17)
Snakebite is a neglected tropical disease with a massive global burden of injury and death. The best current treatments, antivenoms, are plagued by a number of logistical issues that limit supply and access in remote or poor regions. We explore
Who advocates for cryoprecipitate?
Arturo Pereira et al.
Transfusion, 54(5), 1442-1443 (2014-05-14)
Kacey Ronaldson-Bouchard et al.
Nature biomedical engineering, 6(4), 351-371 (2022-04-29)
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here we report the development and
Lorenzo Seneci et al.
Frontiers in immunology, 12, 612846-612846 (2021-04-06)
Rattlesnakes are a diverse clade of pit vipers (snake family Viperidae, subfamily Crotalinae) that consists of numerous medically significant species. We used validated in vitro assays measuring venom-induced clotting time and strength of any clots formed in human plasma and
Dao Lin et al.
iScience, 24(9), 102977-102977 (2021-09-07)
The effective utility of physiologically active molecules is crucial in numerous biological processes. However, the regulation of enzyme functions through active substances remains challenging at present. Here, glutathione (GSH), produced in cells, was used to modulate the catalytic activity of
Justin C Luo et al.
Scientific reports, 10(1), 13144-13144 (2020-08-06)
We introduce laser cavitation rheology (LCR) as a minimally-invasive optical method to characterize mechanical properties within the interior of biological and synthetic aqueous soft materials at high strain-rates. We utilized time-resolved photography to measure cavitation bubble dynamics generated by the
Aleksandra Golenia et al.
Neurologia i neurochirurgia polska, 47(2), 152-156 (2013-05-08)
Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscovered. In the present study, we assessed the significance of
Zhimin Song et al.
Biochemical pharmacology, 178, 114088-114088 (2020-06-13)
Phagocytes, especially neutrophils, can produce reactive oxygen species (ROS), through the activation of the NADPH oxidase (NOX2). Although this enzyme is crucial for host-pathogen defense, ROS production by neutrophils can be harmful in several pathologies such as cardiovascular diseases or
Tímea Feller et al.
Journal of structural biology, 203(3), 273-280 (2018-06-03)
Fibrin plays a fundamentally important role during hemostasis. To withstand the shear forces of blood flow and prevent embolisation, fibrin monomers form a three-dimensional polymer network that serves as an elastic scaffold for the blood clot. The complex spatial hierarchy
Christian Zentai et al.
The Journal of surgical research, 187(2), 616-624 (2013-12-18)
Rapid control of hemorrhage is one of the key aspects in trauma handling. To cope with bleeding, local hemostatic approaches are useful, along with surgical and systemic homostatic therapy. In this experimental study, we investigated the efficacy of a fibrinogen/thrombin
Jay V Karri et al.
The Journal of surgical research, 190(2), 655-661 (2014-03-08)
Fibrinogen is the first coagulation factor to reach critical levels during hemorrhage. Consequently, reestablishing normal fibrinogen levels is necessary to achieve adequate hemostasis. Fibrinogen is supplemented through administration of fresh frozen plasma, cryoprecipitate, or human fibrinogen concentrate, RiaSTAP. RiaSTAP is
Minghua Jiang et al.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 31(2), 134-139 (2014-04-09)
To analyze clinical manifestation and genetic mutations in 8 Chinese pedigrees featuring hereditary dysfibrinogenemia. Prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT), calibration of plasma protamine sulfate against TT, fibrinogen (Fg) activity, coagulation factors II, V, VII, VIII, IX, X
Jordan Debono et al.
Toxicology in vitro : an international journal published in association with BIBRA, 58, 195-206 (2019-04-02)
Envenomations by Asian pitvipers can induce multiple clinical complications resulting from coagulopathic and neuropathic effects. While intense research has been undertaken for some species, functional coagulopathic effects have been neglected. As these species' venoms affect the blood coagulation cascade we
C C Clawson et al.
The American journal of pathology, 98(1), 197-211 (1980-01-01)
Platelets from a patient with congenital afibrinogenemia (CA) were tested in their native plasma for reactivity in vitro to Staphylococcus aureus 502A. Previous studies of the interactions between normal human platelets and this organism have shown rapid irreversible aggregation responses
Brian L Mejak et al.
The journal of extra-corporeal technology, 45(2), 107-111 (2013-08-13)
The timing of blood product administration after cardiopulmonary bypass (CPB) may influence the amount of postoperative transfusion and chest tube output. We performed a retrospective study of a novel technique of administering blood products during modified ultrafiltration (MUF) in congenital
Irina Afonina et al.
mBio, 11(5) (2020-10-22)
Enterococcus faecalis is an opportunistic pathogen, which can cause multidrug-resistant life-threatening infections. Gaining a complete understanding of enterococcal pathogenesis is a crucial step in identifying a strategy to effectively treat enterococcal infections. However, bacterial pathogenesis is a complex process often
Kazuma Takahashi et al.
Acta veterinaria Scandinavica, 55, 70-70 (2013-09-24)
Horse fibrinogen has been identified as a plasma specific ferritin-binding protein. There are two ways in the binding of ferritin-binding protein with ferritin: one is direct binding and the other is indirect binding which is heme-mediated. The aim of this
Shravanthi Rajasekar et al.
Lab on a chip, 22(10), 1929-1942 (2022-04-07)
Organ-on-a-chip systems that recapitulate tissue-level functions have been proposed to improve in vitro-in vivo correlation in drug development. Significant progress has been made to control the cellular microenvironment with mechanical stimulation and fluid flow. However, it has been challenging to
Ana R Almeida et al.
Journal of biomedical materials research. Part A, 108(4), 851-862 (2019-12-18)
Fibrinogen (Fg) is a pro-inflammatory protein with pro-healing properties. Previous work showed that fibrinogen 3D scaffolds (Fg-3D) promote bone regeneration, but the cellular players were not identified. Osteoclasts are bone resorbing cells that promote bone remodeling in close crosstalk with
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