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Showing 1-30 of 71 results for "F6182" within Papers
Raj Putatunda et al.
Journal of neuroinflammation, 15(1), 287-287 (2018-10-14)
Even in the antiretroviral treatment (ART) era, HIV-1-infected patients suffer from milder forms of HIV-1-associated neurocognitive disorders (HAND). While the viral proteins Tat and gp120 have been shown to individually inhibit the proliferation and neural differentiation of neural stem cells
Jackson J Fyfe et al.
Scientific reports, 8(1), 560-560 (2018-01-14)
Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training
Britta Püttmann et al.
Neuro-Signals, 14(3), 85-95 (2005-08-10)
It has previously been shown that skeletal myotubes express nitric oxide synthase (NOS) and produce and release NO signals. NOS is also part of agrin-induced acetylcholine receptor aggregations on myotubes. As nerve-muscle interactions underlie reciprocal signaling mechanisms, we hypothesized that
Kirsten Jahn et al.
Journal of neural transmission (Vienna, Austria : 1996), 124(11), 1341-1367 (2017-09-10)
SH-SY5Y neuroblastoma cells are frequently used for different neuronal cell culture models. As there is no "gold-standard", miscellaneous protocols exist to differentiate these cells into a neuronal cell type. Here, the aim was to find a differentiation condition making cells
Wupu Osimanjiang et al.
Journal of neurotrauma, 37(18), 1954-1962 (2020-04-23)
Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In
Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1
Guan Y, et al.
Oncology Letters, 15(5), 7595-7602 (2018)
Xue-Wei Wang et al.
Cell reports, 24(10), 2540-2552 (2018-09-06)
RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons. We find that Lin28a/b are both necessary and sufficient for supporting axon regeneration in mature
Inga Scheller et al.
Haematologica (2021-08-06)
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes (MKs) but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia and lamellipodia, or clot retraction. Along
Yi Chen et al.
Scientific reports, 9(1), 5624-5624 (2019-04-06)
The tumor microenvironment can be spatially heterogenous, which makes it challenging to fully characterize with standard 2D histology-based methods. In this study, we determined the feasibility of a CLARITY tissue-processing approach to analyze biopsies from breast cancer patients. Formalin-fixed human
Louise M Topping et al.
Frontiers in immunology, 11, 10-10 (2020-03-03)
The targeted delivery of therapies to diseased tissues offers a safe opportunity to achieve optimal efficacy while limiting systemic exposure. These considerations apply to many disease indications but are especially relevant for rheumatoid arthritis (RA), as RA is a systemic
Daniela Anni et al.
Cellular and molecular life sciences : CMLS, 78(11), 4973-4992 (2021-04-18)
Amyloid beta (Aβ) is linked to the pathology of Alzheimer's disease (AD). At physiological concentrations, Aβ was proposed to enhance neuroplasticity and memory formation by increasing the neurotransmitter release from presynapse. However, the exact mechanisms underlying this presynaptic effect as
Charlotte Germonpré et al.
Frontiers in neuroscience, 15, 682036-682036 (2021-07-06)
Intracerebral hemorrhage (ICH) is a known risk factor for the development of acute symptomatic as well as late unprovoked seizures. The underlying pathophysiology of post-ICH seizures is incompletely understood and there are no reliable predictive biomarkers. An animal model to
Yoon Young Cho et al.
Molecules (Basel, Switzerland), 25(23) (2020-12-02)
Amyloid precursor protein (APP) at the plasma membrane is internalized via endocytosis and delivered to endo/lysosomes, where neurotoxic amyloid-β (Aβ) is produced via β-, γ-secretases. Hence, endocytosis plays a key role in the processing of APP and subsequent Aβ generation.
Jason A Halliwell et al.
Current protocols in stem cell biology, 54(1), e115-e115 (2020-06-26)
Human pluripotent stem cells (PSC) acquire recurrent chromosomal instabilities during prolonged in vitro culture that threaten to preclude their use in cell-based regenerative medicine. The rapid proliferation of pluripotent cells leads to constitutive replication stress, hindering the progression of DNA
Patrick M Perrigue et al.
Cancers, 12(7) (2020-07-08)
Cellular senescence is a tumor-suppressive mechanism blocking cell proliferation in response to stress. However, recent evidence suggests that senescent tumor cells can re-enter the cell cycle to become cancer stem cells, leading to relapse after cancer chemotherapy treatment. Understanding how
Mary E Gagou et al.
Oncotarget, 5(22), 11381-11398 (2014-11-02)
Unwinding duplex DNA is a critical processing step during replication, repair and transcription. Pif1 are highly conserved non-processive 5'->3' DNA helicases with well-established roles in maintenance of yeast genome stability. However, the function of the sole member of Pif1 family
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(3), 284-298 (2017-12-19)
CDP diacylglycerol synthase (CDS) catalyses the conversion of phosphatidic acid (PA) to CDP-diacylglycerol, an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PI). CDS activity has been identified in mitochondria and endoplasmic reticulum of mammalian cells apparently encoded
Breton Fougere et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 241, 110639-110639 (2019-12-22)
Cystic Fibrosis Transmembrane conductance Regulator (CFTR) anion channels are the regulated exit pathway in Cl- secretion by teleost salt secreting ionocytes of the gill and opercular epithelia of euryhaline teleosts. By confocal light immunocytochemistry using regular and phospho-antibodies directed against
Matthew D Smith et al.
Developmental cell, 44(2), 217-232 (2018-01-02)
Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health. Here, we identify cell-cycle progression gene 1 (CCPG1), an ER-resident protein with no
Safiye Celik et al.
Genome medicine, 8(1), 66-66 (2016-06-12)
Patterns in expression data conserved across multiple independent disease studies are likely to represent important molecular events underlying the disease. We present the INSPIRE method to infer modules of co-expressed genes and the dependencies among the modules from multiple expression
Nadia Gionchiglia et al.
Biomedicines, 9(9) (2021-09-29)
Phosphorylation of H2AX is a response to DNA damage, but γH2AX also associates with mitosis and/or apoptosis. We examined the effects of X-rays on DNA integrity to shed more light on the significance of H2AX phosphorylation and its relationship with
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(7), 1072-1082 (2019-03-14)
Chronic stimulation (24 h) with vasopressin leads to hypertrophy in H9c2 cardiomyoblasts and this is accompanied by continuous activation of phospholipase C. Consequently, vasopressin stimulation leads to a depletion of phosphatidylinositol levels. The substrate for phospholipase C is phosphatidylinositol (4, 5)
Eric N Anderson et al.
Human molecular genetics, 27(8), 1366-1381 (2018-02-13)
Traumatic brain injury (TBI) has been predicted to be a predisposing factor for amyotrophic lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in ALS progression, the underlying cellular and molecular mechanisms are still an enigma. Here
Katrin Möller et al.
Scientific reports, 9(1), 1055-1055 (2019-02-02)
The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that
Przemysław Duda et al.
Aging, 10(7), 1682-1697 (2018-07-22)
Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes at
Ahmed Baker Alshaikh et al.
Reproductive biology and endocrinology : RB&E, 18(1), 75-75 (2020-07-25)
Fertility preservation is particularly challenging in young women diagnosed with hematopoietic cancers, as transplantation of cryopreserved ovarian cortex in these women carries the risk for re-introducing cancer cells. Therefore, the construction of a bioengineered ovary that can accommodate isolated small
Leonie Walter et al.
In vitro cellular & developmental biology. Animal, 56(5), 386-398 (2020-05-31)
This study aimed to establish an in vitro model for lipid synthesis in primary bovine mammary epithelial cells (pbMECs) extracted from milk and cultured on Transwell permeable supports (TW culture). The suitability of these cells as a functional model for
Layla Simón et al.
PloS one, 12(2), e0172994-e0172994 (2017-02-28)
Hypercholesterolemia is a marker for several adult chronic diseases. Recently we demonstrated that sub/infertility is also associated to Hypercholesterolemia in rabbits. Seminal alterations included: abnormal sperm morphology, decreased sperm number and declined percentage of motile sperm, among others. In this
Jolien Van Cleemput et al.
Nature communications, 12(1), 6612-6612 (2021-11-18)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always confined to the respiratory system, as it impacts people on a broad clinical spectrum from asymptomatic to severe systemic manifestations resulting in death. Further, accumulation of intra-host single nucleotide
Adel B Ghnenis et al.
Scientific reports, 10(1), 2762-2762 (2020-02-19)
More than a quarter of a million individuals in the US live with spinal cord injury (SCI). SCI disrupts neural circuitry to vital organs in the body. Despite severe incidences of long-term peripheral complications from SCI, the cardio-metabolic consequences and
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