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Showing 1-30 of 121 results for "F6879" within Papers
Kuo-Chuan Wang et al.
Journal of neurosurgery, 121(6), 1388-1393 (2014-10-04)
Experimental studies have demonstrated the crucial role of posthemorrhagic erythrocyte catabolism in the pathogenesis of subarachnoid hemorrhage (SAH). The authors of this study aimed to investigate the prognostic value of a series of CSF biomarkers linked to heme metabolism in
Joseph D Mancias et al.
Nature, 509(7498), 105-109 (2014-04-04)
Autophagy, the process by which proteins and organelles are sequestered in double-membrane structures called autophagosomes and delivered to lysosomes for degradation, is critical in diseases such as cancer and neurodegeneration. Much of our understanding of this process has emerged from
Hereditary hyperferritinaemia cataract syndrome.
Oliver Bowes et al.
Lancet (London, England), 383(9927), 1520-1520 (2014-04-29)
Alex Brito et al.
Food and nutrition bulletin, 34(1), 14-20 (2013-06-19)
The Chilean Ministry of Health has combated iron deficiency through the delivery of fortified milk by the National Complementary Feeding Program (NCFP). To assess iron status and associations between biomarkers of iron status and serum C-reactive protein (CRP) in 218
Wei Zhang et al.
Journal of nanoscience and nanotechnology, 13(1), 60-67 (2013-05-08)
Ferritins are natural nanoscale structures composed with 24 subunits endowed with similar three-dimensional structures. The iron is stored in the form of ferrihydrite phosphate in the hollow spherical ferritin shells. Prussian blue nanoparticles (PBNPs) have been certified a kind of
Małgorzata Goralska et al.
Experimental eye research, 125, 135-141 (2014-06-01)
Hypoxia inducible factor (HIF) regulates expression of over 60 genes by binding to hypoxia response elements (HRE) located upstream of the transcriptional start sites. Many genes encoding proteins involved in iron transport and homeostasis are regulated by HIF. Expression of
M Großekatthöfer et al.
Annals of hematology, 92(8), 1121-1128 (2013-04-23)
Clinical presentation and laboratory data are often too unspecific to distinguish the onset or activity of graft-versus-host disease (GvHD) from infections or toxicity. Antigen-presenting cells such as monocytes/macrophages and dendritic cells are involved in GvHD pathogenesis after allogeneic hematopoietic stem
Lale Olcay et al.
Journal of pediatric hematology/oncology, 36(4), 281-292 (2013-07-28)
Iron overload in hereditary hemochromatosis and hematologic malignancy has unfavorable effects on morbidity. Herein, 53 children (age 108.4±58.3 mo, 25 girls and 28 boys) with acute myeloblastic and lymphoblastic leukemia, who received 4 different chemotherapy protocols, were evaluated for iron
B Clevenger et al.
Anaesthesia, 70 Suppl 1, 20-28 (2014-12-03)
Pre-operative anaemia is a relatively common finding, affecting a third of patients undergoing elective surgery. Traditionally associated with chronic disease, management has historically focused on the use of blood transfusion as a solution for anaemia in the peri-operative period. Data
Adalet Meral Gunes et al.
Journal of pediatric hematology/oncology, 36(7), e423-e425 (2014-09-24)
Aceruloplasminemia is a rare autosomal recessive disease that affects the iron metabolism of the body. When there is a lack of ceruloplasmin ferroxidase activity, iron accumulates, especially in the brain, pancreas, liver, and retina. The first symptom is generally a
Ellinor I B Peerschke et al.
American journal of clinical pathology, 142(4), 506-512 (2014-09-23)
Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 μg/dL
Bruno Silva et al.
Annals of hematology, 93(12), 2063-2066 (2014-07-13)
Hereditary hemochromatosis is an autosomal recessive disorder characterized by severe iron overload. It is usually associated with homozygosity for the HFE gene mutation c.845G > A; p.C282Y. However, in some cases, another HFE mutation (c.187C > G; p.H63D) seems to
Andrew J Ghio et al.
American journal of physiology. Lung cellular and molecular physiology, 305(10), L712-L724 (2013-09-03)
Inhalation of particulate matter has presented a challenge to human health for thousands of years. The underlying mechanism for biological effect following particle exposure is incompletely understood. We tested the postulate that particle sequestration of cell and mitochondrial iron is
Chenyan Lv et al.
Biochemistry, 53(14), 2232-2241 (2014-04-01)
From an evolutionary point of view, plant and animal ferritins arose from a common ancestor, but plant ferritin exhibits different features as compared with the animal analogue. One major difference is that the 4-fold channels naturally occurring in plant ferritin
Christine M Pfeiffer et al.
The Journal of nutrition, 143(6), 977S-985S (2013-04-19)
The NHANES 2003-2006 has assessed iron and iodine status, 2 trace element nutrients of continued public health interest, in the U.S. population. We investigated associations of sociodemographic (age, sex, race-ethnicity, education, income) and lifestyle (smoking, alcohol consumption, BMI, physical activity
Bright I Nwaru et al.
The British journal of nutrition, 112(12), 2018-2027 (2014-10-25)
Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however
Samir Awadallah et al.
Clinical laboratory, 59(5-6), 687-691 (2013-07-20)
Total antioxidant capacity (TAC) and ischemia modified albumin (IMA) are common parameters used to assess the status of oxidative stress under different conditions. This study reports on TAC and levels of IMA in patients with beta-thalassemia major. Blood specimens were
Ina Danquah et al.
Tropical medicine & international health : TM & IH, 19(5), 563-567 (2014-06-06)
Acute symptomatic infection with Giardia duodenalis impairs iron absorption, but iron deficiency may protect against infections caused by various micro-organisms including parasites. We therefore examined the association of G. duodenalis infection and iron deficiency in 575 Rwandan children under 5
Amal El-Beshlawy et al.
Annals of hematology, 93(12), 2045-2050 (2014-07-27)
Hydroxycarbamide (hydroxyurea or HU) has been shown to increase fetal hemoglobin (HbF) in patients with β-thalassemia intermedia (TI). The reported effects of HU in increasing the total hemoglobin (Hb) have been inconsistent. Studies of long-term therapy with HU in pediatric
Heinz Ludwig et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(8), 2197-2206 (2014-03-25)
Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Medical oncologists and/or haematologists from nine European countries (n=375) were
Yiouli P Ktena et al.
Journal of pediatric hematology/oncology, 35(6), 447-450 (2013-05-15)
Pediatric oncology patients are often iron overloaded, due to the multiple blood transfusions necessary during the course of chemotherapy. Our aim is to report the efficacy and safety of deferasirox, an oral iron chelator, in this patient group. Deferasirox was
Sebastien Leidgens et al.
The Journal of biological chemistry, 288(24), 17791-17802 (2013-05-04)
The mechanisms through which iron-dependent enzymes receive their metal cofactors are largely unknown. Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that
Bee Koon Poh et al.
The British journal of nutrition, 110 Suppl 3, S21-S35 (2013-09-18)
The dual burden of malnutrition reportedly coexists in Malaysia; however, existing data are scarce and do not adequately represent the nutritional status of Malaysian children. The Nutrition Survey of Malaysian Children was carried out with the aim of assessing the
Grace Salsbury et al.
Experimental hematology, 42(12), 1053-1058 (2014-08-17)
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal
Pin Huan et al.
Gene, 546(1), 80-88 (2014-05-20)
Multiple ferritin subunit genes are reported in mollusks, but they have not been systematically classified. Based on the recently published whole genome sequence, we screened out the four ferritin subunit genes (cgi-fer1-cgi-fer4) from the Pacific oyster Crassostrea gigas. The four
Sarah A Stanley et al.
Nature medicine, 21(1), 92-98 (2014-12-17)
Means for temporally regulating gene expression and cellular activity are invaluable for elucidating underlying physiological processes and would have therapeutic implications. Here we report the development of a genetically encoded system for remote regulation of gene expression by low-frequency radio
Sohail Amjad et al.
Pakistan journal of pharmaceutical sciences, 27(3), 445-452 (2014-05-09)
In Pakistan, a funded flour fortification program was launched for malnourished population, residing mainly in rural low income areas, but the urban population having comparatively better nutritional as well as economic status was focused wherein excessive intake of fortificants might
N M Makarova et al.
Klinicheskaia laboratornaia diagnostika, (1)(1), 42-44 (2013-07-03)
The sample for examination included 52 patients with chronic cardiac failure and 26 patients with anemia amongst. The expected increase of production of prohepsidin against the background of increased serum concentrations of anti-inflammatory cytokines was not detected. The tendency to
Edward Pelle et al.
Journal of cosmetic science, 64(3), 175-179 (2013-06-12)
Menstruation and desquamation are important routes for humans to excrete iron. Because menstruation is no longer available in postmenopausal women, in the present study, we examined whether iron accumulates more in postmenopausal skin than in premenopausal skin. Skin biopsy samples
Mammen Puliyel et al.
American journal of hematology, 89(4), 391-394 (2013-12-19)
Ferritin levels and trends are widely used to manage iron overload and assess the efficacy of prescribed iron chelation in patients with transfusional iron loading. A retrospective cohort study was conducted in 134 patients with transfusion-dependent anemia, over a period
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