Calibration, qualification, and validation
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Showing 1-30 of 75 results
Quantification of Infliximab in Human Serum by LC-MS/MS Using A Full-Length Stable Isotope Labeled Internal Standard
Infliximab, a chimeric monoclonal antibody, is used to treat rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and other autoimmune diseases.
Enzymatic Method for Determining Branched Chain Amino Acids (BCAA Assay)
Assay protocol for the colorimetric detection of Branched Chain Amino Acids (BCAA) in biological samples using the alanine assay kit.
New cis/trans FAME Standard for Optimising GC System Performance
AOCS and AOAC methods for determining the trans fatty acid composition of foods by gas chromatography require the use of a highly polar cyanosilicone capillary column to provide the best peak resolution attainable of the numerous geometric (cis & trans)
Hopane Reference Standards for use as Petrochemical Biomarkers in Oil Field Remediation and Spill Analysis
We provide high-quality, relevant hopane reference standards to be used as biomarkers for petrochemical oil field remediation and spill analysis.
New Certified Reference Materials for α‑Lactalbumin, β‑Lactoglobulin A & B, and Lactoferrin
We have developed Certified Reference Materials (CRMs) of fully intact milk proteins that allow accurate testing of the most critical proteins in infant formula; help labs to develop and test infant formula products with high accuracy, while ensuring legal and
NMR Reference Standards
NMR reference standards ensure proper instrument performance. Review key operational parameters for these standards such as pw90, sensitivity, resolution and line shape.
Traceable Organic Certified Reference Materials for P-31 qNMR
The use of CRMs for the NMR quantification of phosphorylated organic compounds and metabolites offers several advantages as it is based on a signal comparison of the analyte with an internal or external reference standard.
Cannabinoid Certified Reference Materials (CRMs) for an Improved Testing Accuracy and Traceability
We offer a portfolio of cannabinoid CRMs such as THC and THCA, available as single component solutions or mixes, certified in accordance with ISO 17034 and ISO/IEC 17025 for accurate cannabinoid profiling and potency testing.
MRI/MRS: Use of Isotopes in Hyperpolarization
Sigma-Aldrich.com presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.
Chiral and Achiral LC-MS Analysis of Warfarin™ in Plasma Samples
Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples
Melamine Analysis via GC-MS
Sigma-Aldrich presents an article about the analysis of melamine and related compounds in dog food with the use of more economical gas chromatography-mass spectrometry (GC-MS) instrumentation.
Large Molecule BioAnalysis
Bioanalysis for large molecules, like Proteins or specific Biotherapeutics, refer to a set of methods, assays, and procedures that enable scientists to analyze specific proteins found in living organisms and the biochemical reactions underlying life processes.
Vitamin D epi-Metabolites Separated with HybridSPE-Phospholipid
This Sigma-Aldrich article continues to detail new methodology for the analysis of Vitamin D metabolites using HybridSPE-Phospholipid technology.
Analysis of Pesticides in Baby Food by Solid Phase Microextraction (SPME) Using a New Overcoated Fiber
A direct immersion SPME method using a new overcoated SPME fiber was developed for the extraction of pesticides from pureed prune baby food.
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
SPME in the Analysis of Illicit Drugs
SPME is used in the analysis of amphetamine compounds by doing pre-extraction derivatization, and is also used in general determinations of other drugs of abuse.
GC Analysis of a 37-Component FAME Mix on Omegawax®
This technical article will discuss GC Analysis of a 37-Component FAME Mix on Omegawax.
Radiello Diffusive Sampler for Monitoring 1,3-Butadiene and Isoprene in Workplace Air
The manufacturing of elastomers makes wide use of 1,3-butadiene (CAS No. 106-99-0) and isoprene (2-methyl- 1,3-butadiene, CAS No. 78-79-5). Both compounds are classifi ed as carcinogenic by the International Agency for Research on Cancer (IARC). 1,3-Butadiene is currently listed in
Use of 13C Isotopes in MR Research
Dr. Pratip Bhattacharya, California Institute of Technology. "Stable isotopes have played a very useful role in MR research which involves both MRI and MRS.
Calculating Your Working Tolerance: A Guideline
Guideline to calculate your working tolerance - Certified Standard Solutions (CRM)
Analysis of Fats (Fatty Acids, FAMEs, Glycerides) in Food and Beverages
This article explores the analysis of fats in food and beverage products. From derivatization of fatty acids to FAMEs, to analysis of FAME isomers, and more we are your one-stop shop for all of your food and beverage analysis needs.
Aminoglycoside Analysis in Pork Muscle using Molecularly Imprinted Polymer Cleanup and LC/MS/MS Detection
Extraction and quantitative analysis of aminoglycosides in porcine tissue, using molecular imprinted polymer solid phase extraction followed by LC-MS/MS.
An LC/MS Peptide Standard for Rapid System Suitability Assessment and Retention Time Translation Across LC/MS Platforms
Standards are critical in liquid chromatography/mass spectrometry (LC/MS) based proteomics to ensure optimal and consistent system performance before, during, and after sample analysis.
Improved Recoveries and Lower Background for GC/MS/MS and LC/MS/MS Analysis of Pesticides in Green Tea
A procedure for cleanup of green tea extracts provides low background and allowed for the analysis of more pesticides at lower levels than QuEChERS. Uses less solvents and no toluene.
Improving the Chromatographic Separation of DMB-Labeled Sialic Acids for the Comparison of Biosimilars to Reference Materials
A significantly improved HPLC-fluorescence method for DMB-NANA and -NGNA, and application of this method to compare 2 candidate biosimilar therapeutic proteins to their respective RMs.
Improving the Current USP Method for the Analysis of Lansoprazole Drug Substance Using HPLC Columns Based on Fused-Core® Particle Technology
Compendial methods from the USP (United States Pharmacopeia) are widely used in pharmaceutical drug product and raw materials testing. However, not all methods in the USP use modern technologies. In chromatographic methods, it is not uncommon that older brands of
Solution with 17 Amino Acids as TraceCERT® Certified Reference Material
Technical article on "Solution with 17 Amino Acids as TraceCERT® Certified Reference Material"
Drinking Water Testing by Ion Chromatography using Ultrapure Water
This study reviews the suitability of ultrapure water for the IC analysis of drinking water. Inorganic ions and disinfectant by-products (DBPs) were assessed.
Analysis of California Cannabis List of Pesticides, Mycotoxins, and Pyrethrins Using Ascentis® Express Biphenyl Column
Cannabis testing regulations include analysis of purity, potency, and contaminants. Learn more about analysis of cannabis for pesticides, mycotoxins, and pyrethrins registered in California by LC-MS/MS and GC-MS/MS Using Ascentis® Express Biphenyl and SLB®-5ms Columns
How to Choose the Correct Reference Material Quality Grade
Reference materials, standards and certified reference materials are critical for analytical testing. We can help you to choose the ideal reference material for your application, whether you are using reference materials for calibration or quantitative analysis.
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